WO2003012137A3 - Methodes de detection de la maladie de parkinson - Google Patents

Methodes de detection de la maladie de parkinson Download PDF

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Publication number
WO2003012137A3
WO2003012137A3 PCT/FR2002/002761 FR0202761W WO03012137A3 WO 2003012137 A3 WO2003012137 A3 WO 2003012137A3 FR 0202761 W FR0202761 W FR 0202761W WO 03012137 A3 WO03012137 A3 WO 03012137A3
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WO
WIPO (PCT)
Prior art keywords
disease
homozygotic
parkinson
methods
detecting
Prior art date
Application number
PCT/FR2002/002761
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English (en)
Other versions
WO2003012137A2 (fr
Inventor
Gerard Lucotte
Patrice Denefle
Marie-Francoise Rosier
Original Assignee
Aventis Pharma Sa
Gerard Lucotte
Patrice Denefle
Marie-Francoise Rosier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa, Gerard Lucotte, Patrice Denefle, Marie-Francoise Rosier filed Critical Aventis Pharma Sa
Priority to AU2002341044A priority Critical patent/AU2002341044A1/en
Publication of WO2003012137A2 publication Critical patent/WO2003012137A2/fr
Publication of WO2003012137A3 publication Critical patent/WO2003012137A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/172—Haplotypes
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/9116—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • G01N2333/91165—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1)
    • G01N2333/91171—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5) general (2.5.1) with definite EC number (2.5.1.-)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2835—Movement disorders, e.g. Parkinson, Huntington, Tourette

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
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  • Veterinary Medicine (AREA)
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  • Neurology (AREA)
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Abstract

Méthodes de diagnostic ou de pronostic de la maladie de Parkinson chez un sujet. Ladite méthode comprend les étapes de détection de la présence ou de l'absence de la mutation homozygote CYP2D6-B d'une part, et de la délétion homozygote de GSTM1 d'autre part. La présence conjointe de la mutation homozygote CYP2D6-B et de la délétion homozygote de GSTM1 indique que le sujet peut être atteint de la maladie de Parkinson ou bien présente un risque accru de développer la maladie de Parkinson.
PCT/FR2002/002761 2001-08-03 2002-07-31 Methodes de detection de la maladie de parkinson WO2003012137A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002341044A AU2002341044A1 (en) 2001-08-03 2002-07-31 Methods for detecting parkinson's disease

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0110456A FR2828212B1 (fr) 2001-08-03 2001-08-03 Methodes de diagnostic et de pronostic de la maladie de parkinson
FR01/10456 2001-08-03

Publications (2)

Publication Number Publication Date
WO2003012137A2 WO2003012137A2 (fr) 2003-02-13
WO2003012137A3 true WO2003012137A3 (fr) 2004-02-26

Family

ID=8866283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2002/002761 WO2003012137A2 (fr) 2001-08-03 2002-07-31 Methodes de detection de la maladie de parkinson

Country Status (3)

Country Link
AU (1) AU2002341044A1 (fr)
FR (1) FR2828212B1 (fr)
WO (1) WO2003012137A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070269790A1 (en) * 2003-12-01 2007-11-22 Technion Research & Development Methods of Generating Stem Cells and Embryonic Bodies Carrying Disease-Causing Mutations and Methods of Using same for Studying Genetic Disorders
DE10361258A1 (de) 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
DE10361259A1 (de) * 2003-12-24 2005-07-28 Schwarz Pharma Ag Verwendung von Rotigotine in einem Frühstadium von Morbus Parkinson zur Prävention des weiteren Neuronenverlustes
DE102004014841B4 (de) 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
NZ584363A (en) 2007-11-28 2012-11-30 Ucb Pharma Gmbh Drug formulations of Rotigotine which comprise the thermodynamically stable polymorphic form 2

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055853A1 (fr) * 1998-04-28 1999-11-04 Takeda Chemical Industries, Ltd. Lignee cellulaire hepatique immortalisee d'origine humaine
WO2001010902A2 (fr) * 1999-08-11 2001-02-15 Curagen Corporation Polynucleotides et polypeptides codes par ces derniers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999055853A1 (fr) * 1998-04-28 1999-11-04 Takeda Chemical Industries, Ltd. Lignee cellulaire hepatique immortalisee d'origine humaine
WO2001010902A2 (fr) * 1999-08-11 2001-02-15 Curagen Corporation Polynucleotides et polypeptides codes par ces derniers

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DALVI A ET AL: "ANTIPARKINSONIAN AGENTS CLINICALLY SIGNIFICANT DRUG INTERACTIONS AND ADVERSE EFFECTS, AND THEIR MANAGEMENT", CNS DRUGS, ADIS INTERNATIONAL, AUCKLAND, NZ, vol. 9, no. 4, April 1998 (1998-04-01), pages 291 - 310, XP000989835, ISSN: 1172-7047 *
MCCANN S ET AL: "The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis", JOURNAL OF NEUROLOGICAL SCIENCES, vol. 153, no. 1, December 1997 (1997-12-01), pages 50-53, XP001064818 *
NICHOLL D ET AL: "A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders", NEUROLOGY, vol. 53, no. 7, October 1999 (1999-10-01), pages 1415 - 21, XP001064820 *
PALMA G ET AL: "Case-control study of interactions between genetic environmental factors in Parkinson's disease", LANCET, vol. 52, 19 December 1998 (1998-12-19), pages 1986 - 87, XP002196457 *
RAHBAR A ET AL: "Glutathionine S-transferase polymorphism in Parkinson's disease", JOURNAL OF NEURAL TRANSMISSION, vol. 107, no. 3, March 2000 (2000-03-01), pages 331 - 34, XP001064823 *
STROOMBERGEN C ET AL: "Determination of glutathione S-transferase mu and theta polymorphisms in neurological disease", HUMAN AND EXPERIMENTAL TOXICOLOGY, vol. 18, no. 3, March 1999 (1999-03-01), pages 141 - 45, XP001064817 *
TAN E ET AL: "Variability and validity of polymorphism association studies in Parkinson?s disease", NEUROLOGY, vol. 55, no. 4, August 2000 (2000-08-01), pages 533 - 38, XP001064819 *

Also Published As

Publication number Publication date
AU2002341044A1 (en) 2003-02-17
WO2003012137A2 (fr) 2003-02-13
FR2828212B1 (fr) 2003-10-31
FR2828212A1 (fr) 2003-02-07

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