WO2003011828A3 - Nouveaux analgesiques - Google Patents

Nouveaux analgesiques Download PDF

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Publication number
WO2003011828A3
WO2003011828A3 PCT/US2002/023686 US0223686W WO03011828A3 WO 2003011828 A3 WO2003011828 A3 WO 2003011828A3 US 0223686 W US0223686 W US 0223686W WO 03011828 A3 WO03011828 A3 WO 03011828A3
Authority
WO
WIPO (PCT)
Prior art keywords
attached
salt
integer
nitrogen
heterocyclic ring
Prior art date
Application number
PCT/US2002/023686
Other languages
English (en)
Other versions
WO2003011828A2 (fr
Inventor
Richard A Glennon
Billy R Martin
Malgozata Dukat
Imad M Damaj
Original Assignee
Univ Virginia Commonwealth
Richard A Glennon
Billy R Martin
Malgozata Dukat
Imad M Damaj
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia Commonwealth, Richard A Glennon, Billy R Martin, Malgozata Dukat, Imad M Damaj filed Critical Univ Virginia Commonwealth
Priority to AU2002327340A priority Critical patent/AU2002327340A1/en
Publication of WO2003011828A2 publication Critical patent/WO2003011828A2/fr
Publication of WO2003011828A3 publication Critical patent/WO2003011828A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention se rapporte à un sel représenté par la formule I dans laquelle R?1, R2 et R3¿ sont indépendamment choisis dans le groupe consistant en groupes alkyles C¿1-6? ou n'importe lequel des R?1, R2 et R3¿ peuvent, ensemble avec l'atome de nitrogène auquel ils sont attachés, former un noyau hétérocyclique. R4 est choisi dans le groupe des fractions qui sont capables de modifier la solubilité du composé dans des fluides physiologiques et dans des supports pharmaceutiques, n est un chiffre entier compris entre 0 et 5, A est choisi dans le groupe hydrogène ou peut, avec le carbone auquel il est attaché et avec n'importe lequel des R?1, R2 et R3¿ et l'atome de nitrogène auquel ils sont attachés, former un noyau hétérocyclique. X est un contre-ion chargé négatif et p représente le nombre de charges négatives, le nombre de molécules de l'ion amino tertiaire chargé positif égal au chiffre entier p dans n'importe quel sel. De préférence, ce sel est représente par la formule II.
PCT/US2002/023686 2001-07-31 2002-07-25 Nouveaux analgesiques WO2003011828A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002327340A AU2002327340A1 (en) 2001-07-31 2002-07-25 3-pyridylether rerivatives and their use as analgesics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30855701P 2001-07-31 2001-07-31
US60/308,557 2001-07-31

Publications (2)

Publication Number Publication Date
WO2003011828A2 WO2003011828A2 (fr) 2003-02-13
WO2003011828A3 true WO2003011828A3 (fr) 2003-10-16

Family

ID=23194447

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023686 WO2003011828A2 (fr) 2001-07-31 2002-07-25 Nouveaux analgesiques

Country Status (2)

Country Link
AU (1) AU2002327340A1 (fr)
WO (1) WO2003011828A2 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040682A1 (fr) * 1995-06-07 1996-12-19 Abbott Laboratories Composes d'ether heterocyclique de 3-pyridyloxyalkyle utiles pour reguler la transmission synaptique chimique

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040682A1 (fr) * 1995-06-07 1996-12-19 Abbott Laboratories Composes d'ether heterocyclique de 3-pyridyloxyalkyle utiles pour reguler la transmission synaptique chimique

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ABREO M A ET AL: "NOVEL 3-PYRIDYL ETHERS WITH SUBNANOMOLAR AFFINITY FOR CENTRAL NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 39, 1996, pages 817 - 825, XP002931256, ISSN: 0022-2623 *
HOLLADAY ET AL: "Neuronal Nicotinic Acetylcholine Receptros as Targets for Drug Discovery", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. WASHINGTON, US, vol. 40, no. 26, 19 December 1997 (1997-12-19), pages 4169 - 4194, XP002124847, ISSN: 0022-2623 *

Also Published As

Publication number Publication date
WO2003011828A2 (fr) 2003-02-13
AU2002327340A1 (en) 2003-02-17

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