WO2003008590A1 - Gpat mitochondrien humain - Google Patents

Gpat mitochondrien humain Download PDF

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Publication number
WO2003008590A1
WO2003008590A1 PCT/JP2002/007189 JP0207189W WO03008590A1 WO 2003008590 A1 WO2003008590 A1 WO 2003008590A1 JP 0207189 W JP0207189 W JP 0207189W WO 03008590 A1 WO03008590 A1 WO 03008590A1
Authority
WO
WIPO (PCT)
Prior art keywords
human mitochondrial
mitochondrial gpat
protein
antagonist
screening
Prior art date
Application number
PCT/JP2002/007189
Other languages
English (en)
Japanese (ja)
Inventor
Sakae Sakamoto
Hideki Onota
Sumio Sugano
Yusuke Nakamura
Original Assignee
Kissei Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Publication of WO2003008590A1 publication Critical patent/WO2003008590A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Obesity (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne une protéine ayant une activité de sn-glycérol-3-phosphate acyltransférase (GPAM) mitochondrienne humaine; et un procédé de criblage d'un antagoniste à l'aide de cette protéine. L'antagoniste de la protéine précitée obtenu par le procédé de criblage sert de remède lors de complications diabétiques.
PCT/JP2002/007189 2001-07-16 2002-07-16 Gpat mitochondrien humain WO2003008590A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-215337 2001-07-16
JP2001215337 2001-07-16

Publications (1)

Publication Number Publication Date
WO2003008590A1 true WO2003008590A1 (fr) 2003-01-30

Family

ID=19049997

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/007189 WO2003008590A1 (fr) 2001-07-16 2002-07-16 Gpat mitochondrien humain

Country Status (1)

Country Link
WO (1) WO2003008590A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057188A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2002016592A2 (fr) * 2000-08-21 2002-02-28 Millennium Pharmaceuticals, Inc. Nouvelle acyltransferase humaine atcr-1 et ses utilisations
WO2002026950A2 (fr) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Transferases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057188A2 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Nouveaux acides nucleiques et polypeptides
WO2002016592A2 (fr) * 2000-08-21 2002-02-28 Millennium Pharmaceuticals, Inc. Nouvelle acyltransferase humaine atcr-1 et ses utilisations
WO2002026950A2 (fr) * 2000-09-29 2002-04-04 Incyte Genomics, Inc. Transferases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BHAT B. GANESH ET AL.: "Rat sn-glycerol-3-phosphate acyltransferase: molecular cloning and characterization of the cDNA and expressed protein", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1439, 1999, pages 415 - 423, XP002957627 *
DONG-HOON SHIN ET AL.: "Transcriptional regulation of p90 with sequence homology to escherichia coli glycerol-3-phosphate acyltransferase", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 265, no. 35, 1991, pages 23834 - 23839, XP001095625 *
HEI SOOK SUL ET AL.: "Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription", ANNU. REV. NUTR., vol. 18, 1998, pages 331 - 351, XP002957629 *
SHAW-FANG YET ET AL.: "Purification and reconstitution of murine mitochondrial glycerol-3-phosphate acyltransferase. Functional expression in baculovirus-infected insect cells", BIOCHEMISTRY, vol. 34, 1995, pages 7303 - 7310, XP002957628 *
TAKAHIRO NAGASE ET AL.: "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins", DNA RESEARCH, vol. 7, 2000, pages 273 - 281, XP001012454 *

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