WO2003006628A3 - Nad synthetase inhibitors and uses thereof - Google Patents

Nad synthetase inhibitors and uses thereof Download PDF

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Publication number
WO2003006628A3
WO2003006628A3 PCT/US2002/005172 US0205172W WO03006628A3 WO 2003006628 A3 WO2003006628 A3 WO 2003006628A3 US 0205172 W US0205172 W US 0205172W WO 03006628 A3 WO03006628 A3 WO 03006628A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
alkylenyl
disclosed
optionally
alkyl
Prior art date
Application number
PCT/US2002/005172
Other languages
French (fr)
Other versions
WO2003006628A2 (en
Inventor
Wayne J Brouillette
Lawrence J Delucas
Christie G Brouillette
Sadanandan E Velu
Yong-Chul Kim
Liyuan Mou
R Stephen Porter
Original Assignee
Virtual Drug Dev Inc
Uab Research Foundation
Wayne J Brouillette
Lawrence J Delucas
Christie G Brouillette
Sadanandan E Velu
Yong-Chul Kim
Liyuan Mou
R Stephen Porter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/022203 external-priority patent/WO2002007516A2/en
Application filed by Virtual Drug Dev Inc, Uab Research Foundation, Wayne J Brouillette, Lawrence J Delucas, Christie G Brouillette, Sadanandan E Velu, Yong-Chul Kim, Liyuan Mou, R Stephen Porter filed Critical Virtual Drug Dev Inc
Priority to EP02723209A priority Critical patent/EP1578898A2/en
Priority to JP2003512387A priority patent/JP2005509594A/en
Publication of WO2003006628A2 publication Critical patent/WO2003006628A2/en
Publication of WO2003006628A3 publication Critical patent/WO2003006628A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1-X-Ar2-Y-L-Z-Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1, Ar2, and Ar3 are independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Q1 is an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof. Also disclosed are methods which involve the use of the compounds of the present invention, for example, in treating or preventing a microbial infection in a mammal or plant, killing a prokaryote or decreasing prokaryotic growth, disinfecting a material or environment contaminated by a microbe, increasing food animal production, controlling harm to plants by a pest or insect and combating agroterrorism. Examples of microbes affected by the compounds of the present invention are bacteria and fungi.
PCT/US2002/005172 2001-07-13 2002-02-22 Nad synthetase inhibitors and uses thereof WO2003006628A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02723209A EP1578898A2 (en) 2001-07-13 2002-02-22 Nad synthetase inhibitors and uses thereof
JP2003512387A JP2005509594A (en) 2001-07-13 2002-02-22 NAD synthetase inhibitors and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USPCT/US01/22203 2001-07-13
PCT/US2001/022203 WO2002007516A2 (en) 2000-07-14 2001-07-13 Uses for nad synthetase inhibitors

Publications (2)

Publication Number Publication Date
WO2003006628A2 WO2003006628A2 (en) 2003-01-23
WO2003006628A3 true WO2003006628A3 (en) 2006-10-26

Family

ID=21742699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005172 WO2003006628A2 (en) 2001-07-13 2002-02-22 Nad synthetase inhibitors and uses thereof

Country Status (3)

Country Link
EP (1) EP1578898A2 (en)
JP (1) JP2005509594A (en)
WO (1) WO2003006628A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005002337A1 (en) * 2003-04-02 2005-01-13 Virtual Drug Development, Inc. Disinfectant compositions and methods
WO2005033079A1 (en) 2003-09-30 2005-04-14 Eisai Co., Ltd. Novel antifungal agent comprising heterocyclic compound
US7829585B2 (en) 2005-03-30 2010-11-09 Eisai R&D Management Co., Ltd. Antifungal agent containing pyridine derivative
EP1940786B1 (en) 2005-09-16 2010-08-18 Arrow Therapeutics Limited Biphenyl derivatives and their use in treating hepatitis c
TWI385169B (en) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd Heterocyclic substituted pyridine derivatives and antifungal agent containing same
WO2008035726A1 (en) 2006-09-21 2008-03-27 Eisai R & D Management Co., Ltd. Pyridine derivative substituted by heteroaryl ring, and antifungal agent comprising the same
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
CN101622251B (en) 2007-04-27 2012-07-04 卫材R&D管理有限公司 Salt of heterocycle-substituted pyridine derivative or crystal thereof
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
US8188119B2 (en) 2008-10-24 2012-05-29 Eisai R&D Management Co., Ltd Pyridine derivatives substituted with heterocyclic ring and γ-glutamylamino group, and antifungal agents containing same
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
UY33337A (en) 2010-10-18 2011-10-31 Respivert Ltd SUBSTITUTED DERIVATIVES OF 1H-PIRAZOL [3,4-d] PYRIMIDINE AS INHIBITORS OF PHOSFOINOSITIDE 3-KINASES
GB201104153D0 (en) 2011-03-11 2011-04-27 Glaxo Group Ltd Novel compounds
SG11201404522VA (en) 2012-03-13 2014-10-30 Respivert Ltd Crystalline pi3 kinase inhibitors
CN107312039B (en) 2012-08-30 2019-06-25 江苏豪森药业集团有限公司 A kind of preparation method of tenofovir prodrug
US9227977B2 (en) 2013-03-15 2016-01-05 Respivert Ltd. Phosphoinositide 3-kinase inhibitors
JO3279B1 (en) 2013-03-15 2018-09-16 Respivert Ltd 2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-(trifluoromethyl)benzyl)quinazolin-4(3h)-one derivatives and their use as phosphoinositide 3-kinase inhibitors
GB201415569D0 (en) 2014-09-03 2014-10-15 C4X Discovery Ltd Therapeutic Compounds
GB201601703D0 (en) 2016-01-29 2016-03-16 C4X Discovery Ltd Therapeutic compounds
JP2020527133A (en) 2017-06-20 2020-09-03 インブリア ファーマシューティカルズ， インコーポレイテッド Compositions and Methods for Increasing the Efficiency of Cardiac Metabolism
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275068A (en) * 1977-08-29 1981-06-23 Siegfried Ag Lipid lowering alkylene glycols and ester derivatives thereof
US4289777A (en) * 1978-12-28 1981-09-15 Schering, Aktiengesellschaft Quinolonecarboxylic acid derivatives and pharmaceutical preparations thereof for treatment of an allergic disease of the respiratory tract
US4767712A (en) * 1983-04-25 1988-08-30 Toyo Jozo Kabushiki Kaisha Assay method using nad synthetase and a process for production of the enzyme
US5932743A (en) * 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds
US6228588B1 (en) * 1995-09-15 2001-05-08 Microcide Pharmaceuticals, Inc. Methods of screening for compounds active on Staphylococcus aureus target genes

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4275068A (en) * 1977-08-29 1981-06-23 Siegfried Ag Lipid lowering alkylene glycols and ester derivatives thereof
US4289777A (en) * 1978-12-28 1981-09-15 Schering, Aktiengesellschaft Quinolonecarboxylic acid derivatives and pharmaceutical preparations thereof for treatment of an allergic disease of the respiratory tract
US4767712A (en) * 1983-04-25 1988-08-30 Toyo Jozo Kabushiki Kaisha Assay method using nad synthetase and a process for production of the enzyme
US6228588B1 (en) * 1995-09-15 2001-05-08 Microcide Pharmaceuticals, Inc. Methods of screening for compounds active on Staphylococcus aureus target genes
US5932743A (en) * 1997-08-21 1999-08-03 American Home Products Corporation Methods for the solid phase synthesis of substituted indole compounds

Also Published As

Publication number Publication date
EP1578898A2 (en) 2005-09-28
WO2003006628A2 (en) 2003-01-23
JP2005509594A (en) 2005-04-14

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