WO2003005993A1 - Core formulation comprising troglitazone and a biguanide - Google Patents
Core formulation comprising troglitazone and a biguanide Download PDFInfo
- Publication number
- WO2003005993A1 WO2003005993A1 PCT/US2001/021616 US0121616W WO03005993A1 WO 2003005993 A1 WO2003005993 A1 WO 2003005993A1 US 0121616 W US0121616 W US 0121616W WO 03005993 A1 WO03005993 A1 WO 03005993A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- patient
- troglitazone
- glucopyranosyl
- core
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
Definitions
- This invention relates to a core formulation, and, more particularly, to a core formulation comprising a first layer comprising troglitazone, which covers at least a portion of a core comprising a biguanide, such as for example metformin (i.e., glucophage), with a modulating release polymer comprising a silicate.
- a core formulation comprising a first layer comprising troglitazone, which covers at least a portion of a core comprising a biguanide, such as for example metformin (i.e., glucophage), with a modulating release polymer comprising a silicate.
- Metformin and troglitazone are two active ingredients of anti-diabetic drugs that are used to treat diabetic patients, e.g. human beings. These two active agents are administered orally to patients in need thereof in protocols calling for the single administration of either ingredient.
- a physically combined core formulation comprising both ingredients.
- the advantage of such a core formulation is advantageous to patients and prescribers because both medicaments are s iicrgistic to each other in the body when used in the management of blood glucose control, i.e., diabetes.
- a modulating agent like silica gel, in the preparation, controls the rate of drug release over a clinically meaningful period to enable better control of the effect of the medicinal agents in such preparation.
- This invention relates to a core formulation, and, more particularly, to a core formulation comprising a first layer comprising troglitazone or a derivative thereof, e.g. troglitazone hydrochloride, which covers at least a portion of a core comprising a biguanide, one or both of which are intimately dispersed in a silicate based modulating agent.
- a core formulation comprising a first layer comprising troglitazone or a derivative thereof, e.g. troglitazone hydrochloride, which covers at least a portion of a core comprising a biguanide, one or both of which are intimately dispersed in a silicate based modulating agent.
- metformin typically is used clinically as a pharmaceutically acceptable salt, preferably the hydrochloride salt.
- hydrochloride salt preferably the hydrochloride salt.
- metformin hydrochloride is available as glucophage. Its chemical name is
- Metformin hydrochloride is a hydrochloride salt of metformin base, and as used herein,
- Metformin means the base compound as well as its pharmaceutically acceptable salts. Metformin is used clinically to manage non-insulin dependent diabetes mellitus ("NIDDM"), particularly in patients who are not effectively treated with a sulfonylurea. While it is not chemically related to the sulfonylureas, it is routinely utilized in combination with a sulfonylurea, and has been shown to be synergistic in some cases. Other biguanides such as phenformin, buformin etc. can also be used. Additionally, in the treatment of a diabetic patient the metformin and the troglitazone, e.g. its hydrochloride, are present in effective amounts to provide such treatment.
- NIDDM non-insulin dependent diabetes mellitus
- Metformin is an active ingredient for a commercially available drug employed to treat diabetes mellitus in a host or mammal, e.g. a human being, another animal.
- the typical daily effective dose for the oral treatment of a mammal, i.e., a human ranges from about 500 mg to about 2550 mg.
- the dose is a single dose of about 500 mg to about 850 mg.
- Troglitazone hydrochloride (Rezulin®) is an active ingredient for a commercially available drug employed to treat diabetes mellitus in a host, e.g. a human being.
- the typical daily effective dose for the oral administration to a mammal, e.g. a human being ranges from about 200 mg to about 400 mg, given as a single dose.
- Silicates are pharmaceutical excipients generally regarded as safe and used therefore to prepare a variety of pharmaceutical systems well documented in the patent literature.
- the silicates have not been shown to modulate the release of the hypoglycemic drugs metformin and pioglitazone hydrochloride when administered together to try to improve the control and effectiveness of either drug, although co-administration of the two has been proposed [Whitcomb; et al, United States Patent No. 6,011,049].
- a combined form of the drugs i.e. a single integral unit thereof has not heretofore been reported.
- the present invention provides such a single integral unit in the form of a core formulation.
- a typical silicate for this purpose is Purified Siliceous Earth
- silica gel also known in some forms as silica gel or fumed silica. It is typically used in oral pharmaceutical preparations as a bulking agent.
- silicate means silicic acid, disilicic acid, trisilicic acid, metasilicic acid, and orthosilicic acid in their free or salt forms; silicon dioxide in either of its amporphous, crystalline, or precipitated forms; diatomacous earth; Fuller's earth,
- Kieselhurh Celite; talc; attapulgite; micas; clays such as montmorilonite (MontmoriloniteTM), kaolin, aluminum oxide (Hydrargilite), bentone (BentoniteTM), bentonite (Bentonite MagmaTM) and pumice; silanes and siloxanes. These are used typically as adsorbents, carriers, dispersants, fillers, thickeners.
- the relative concentrations of each drug is such that a first layer comprising troglitazone is prepared.
- the first layer covers at least a portion of a core comprising metformin, with a portion or all of the amount of the silicate.
- the first layer may cover only a portion of the core or encompass the entire core. For example, one quarter of the core to about three fourths of the tablet core.
- the first layer should comprise troglitazone hydrochloride, with or without any silicate, because its dose requirement is lower compared to metformin. Additionally, troglitazone hydrochloride is slightly non- polar, its solubility rate is slower, and its absorption rate thus is dependent on its dissolution rate in the contents of the gastrointestinal tract compared with metformin.
- either the first layer or the core may additionally contain a mixture of the two active ingredients or both the first layer and the core may contain the two active ingredients with different and varying concentrations of one or both active ingredients.
- the first layer of the core comprises troglitazone, e.g. its hydrochloride, in an amount of about 0.01 % to about 20% of the total weight of the core formulation, whereas, the metformin in the core is present in an amount of about 10% to about 91.5% of the total weight of the core formulation.
- troglitazone e.g. its hydrochloride
- troglitazone e.g. its hydrochloride
- metformin ranges from about 100 mg to about 2550 mg.
- a third pharmacologically active material e.g. a drug, such as for example a sulfonylurea, an ⁇ -glucosidase inhibitor, a meglitinide, and an ACE inhibitor can admixed with the active ingredients in the first layer and/or the core.
- a drug such as for example a sulfonylurea, an ⁇ -glucosidase inhibitor, a meglitinide, and an ACE inhibitor
- a drug such as for example a sulfonylurea, an ⁇ -glucosidase inhibitor, a meglitinide, and an ACE inhibitor
- alpha.-glucosidase inhibitors [Jean-Bernard Ducep et al., US Patent No. 5,504,078], bisglucosylmoranoline derivatives [UK Patent No. GB 2 088 365 A], and glucosylmoranoline derivatives [European Patent No.
- the list of medicaments includes acid addition salt forms with such inorganic acids, such as, for example, hydrochloric, hydrobrornic, sulfuric, phosphoric and like acids; with organic carboxylic acids such as, for example, acetic, propionic, glycolic, lactic, pyruvic, malonic, succinic, fumaric, maleic, tartaric, citric, ascorbic, maleic, hydroxymaleic, dihydroxymaleic, benzoic, 2- acetoxybenzoic, mandelic and like acids; and with organic sulfonic acids such as methanesulfonic acid and p-toluenesulfonic acid.
- organic carboxylic acids such as, for example, acetic, propionic, glycolic, lactic, pyruvic, malonic, succinic, fumaric, maleic, tartaric, citric, ascorbic, maleic, hydroxymaleic, dihydroxymaleic, benzoic, 2- acetoxybenzoic, mandelic and like
- the sulfonylureas are a class of compounds that have been widely employed to treat diabetes. Such compounds are well known, for example, as described in U.S. Pat. Nos. 3,454,635; 3,669,966; 2,968,158; 3,501,495; 3,708,486;
- sulfonylureas to be employed in the combinations or core formulations of this invention are glyburide, gliquidone, glipizide, tolbutamide, tolazamide, glisoxepid, chlorpropamide, glibornuride, gliclazide, glimepiride, phenbutamide, and tolcyclamide.
- Other medicaments such as, for example, an antibiotic, a vitamin, a drug that works on the heart or in the liver, may be admixed with the active ingredients in the first layer and/or the core.
- the modulating silicate polymer e.g., silica gel
- the modulating silicate polymer may be associated with the metformin core alone or with the first layer alone or with both the metformin and troglitazone hydrochloride.
- the type of association as well as the concentration of the modulating agent is dependent upon the concentrations of the core active ingredient, and the layer active ingredient, the degree of coverage of the core by the first layer and the desired rate of administration of each active ingredient.
- the resultant core having the first layer thereon is prepared by any conventional means known in the pharmaceutical art, e.g. compression, tabletting technology, spraying technology, or encapsulation in a pharmaceutically acceptable presentation, such as a gelatin capsule.
- a pharmaceutically acceptable presentation such as a gelatin capsule.
- typically the core formulation of the present invention is preferably fabricated by compression into a tablet.
- the resultant core formulation of the present invention is useful to treat diabetes mellitus.
- the resultant core formulation of the invention is as user friendly and clinically effective as compared to the administration of metformin alone or troglitazone hydrochloride alone as demonstrated by co- administration of the two agents [Whitcomb; et al, United States Patent No.
- the core formulation of the present invention may be administered orally, for example, with inert diluent or with an edible carrier.
- the core formulation may have other excipients incorporated therein.
- the subject core formulation may also contain the following adjuvants: a binder such as microcrystalline cellulose, gum tragacanth or gelatin; an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel®, corn starch and the like; a lubricant such as magnesium stearate or Sterotex; a glidant such as colloidal silicon dioxide; and a sweetening agent such as sucrose or saccharin may be added or a flavoring agent such as peppermint, methyl salicylate or orange flavoring.
- a binder such as microcrystalline cellulose, gum tragacanth or gelatin
- an excipient such as starch or lactose, a disintegrating agent such as alginic acid, Primogel®, corn starch and the like
- a lubricant such as magnesium stearate or Sterotex
- a glidant such as colloidal silicon dioxide
- a sweetening agent such as sucrose or sac
- the subject core formulation of the invention may contain other various materials which modify the physical form of the dosage unit (the subject core formulation), for example, as coatings.
- the subject core formulation of the present invention may be coated with sugar, shellac or other enteric coating agents. Materials used in preparing these various compositions should be pharmaceutically pure and non-toxic in the amounts used.
- the resultant core formulation (having a first layer completely or partially covering the core), is treated whereby an outer shell is formed, at least a portion of which comprises the biodegradable modulating silicate material present in an amount having a predetermined rate of degradation or metabolism in the host being treated,.
- the silicate material is a high molecular weight compound, which is physiologically acceptable and excreted from the body of the human being or other animal almost intact.
- the biodegradable silicate material comprising the outer shell, having a predetermined rate of degradation or metabolism or break down, is selected from silic acid and its derivatives, examples of which include those listed previously.
- the shell encapsulating the particles of pioglitazone hydrochloride of the first layer and/or the particles of metformin of the core is obtained by any conventional microencapsulation process whereby microspheres of metformin and/or pioglitazone hydrochloride are formed, e.g. a solvent removal process, a phase separation technique, coacervation etc.
- a solvent removal process e.g. a solvent removal process, a phase separation technique, coacervation etc.
- the resultant core formulation is treated whereby only the top surface area of the first layer comprising pioglitazone hydrochloride has a shell coating thereon.
- U.S. Patent No. 5,916,584, incorporated hereinto by reference in its entirety which describes the process for forming such a shell.
- the resulting core formulation having the first layer encapsulated by the shell comprising the shell material is one which provides a delay time prior to release of the active ingredients, i.e. pioglitazone hydrochloride and metformin, to the patient being treated for diabetes mellitus.
- the resultant core formulation (having a first layer completely or partially covering the core), is treated with a outer shell comprising a natural polysaccaride, in its free acid a or salt form such as guar gum; gum arabic; gum karaya; gum Benjamin, plantago ovata gum; agar; carrageenan; cellulose; gelatin; pectin; or galacturonic acid is formed which encloses the particles of the first layer and/or the core.
- a natural polysaccaride in its free acid a or salt form such as guar gum; gum arabic; gum karaya; gum Benjamin, plantago ovata gum; agar; carrageenan; cellulose; gelatin; pectin; or galacturonic acid is formed which encloses the particles of the first layer and/or the core.
- Silicates are naturally occurring polymers consisting of silicon chains. These polymers have the propensity to absorb water thus swelling to become gel-like structures in solution. The gel dissolves slowly thus releasing its drug payloads in a dissolution controlled manner.
- the silicate shell provides excellent stability to the core formulation while at the same time modulates drug release.
- the silicate shell swells to become a gel-like structure in solution in the body of the patient, e.g. the stomach.
- the gel ultimately dissolves slowly, e.g. typically, in several minutes to a few hours, usually within a day, releasing its drug payload, e.g. metformin and/or pioglitazone hydrochloride in a dissolution controlled manner.
- the polymer shell encapsulating the particles of troglitazone, e.g. its hydrochloride, of the first layer and/or the particles of metformin of the core is obtained by any conventional microencapsulation process whereby microspheres of metformin and/or troglitazone, e.g. its hydrochloride, are formed, e.g. a solvent removal process, a phase separation technique, coacervation etc.
- a solvent removal process e.g. a solvent removal process, a phase separation technique, coacervation etc.
- the resultant core formulation is treated whereby only the top surface area of the first layer comprising troglitazone has a shell coating, e.g. silical gel, thereon.
- a shell coating e.g. silical gel
- the resulting core formulation having the first layer encapsulated by the shell comprising the polymer shell material is one which provides a delay time prior to release of the active ingredients, i.e. troglitazone and metformin, to the patient being treated for diabetes mellitus.
- the amount of the polymer, e.g. fumed silica gel, employed will depend upon the medicament release profile desired, the particular polymer employed, the particular medicament or medicaments encapsulated or coated and the thickness of the coat of polymer contained on the particular medicament. Such amount can be readily determined by those of ordinary skill in the art with due consideration of the factors set forth above.
- the polymer e.g. silica gel
- the polymer is first combined or mixed with at least one of the medicaments, e.g. the troglitazone hydrochloride first layer, whereafter the resultant core having the first layer thereon is prepared in any conventional manner, e.g. compression into a tablet.
- the amount of the polymer combined or mixed with at least one of the medicaments depends on the medicament release profile desired. This is readily determined by one of ordinary skill in the art. Typically, for a release of of about 2 to 6 hours, the thickness ranges from about
- the polymer e.g. silica gel
- association or
- association is meant that the natural polysaccharide polymer, either fully or partially coats or encompass the particles of at least one medicament, e.g. the first layer of troglitazone, or is combined or mixed with the particles of at least one medicament, e.g. metformin, prior to forming the resulting core medicament, in the formation of a modulate release core formulation.
- any pharmaceutically acceptable form encompasses the free acids, free bases, salts and various hydrate forms, including semi-hydrate forms of these medicaments, as well as other pharmaceutical materials which are used in the formulation process as acceptable excipient materials generally known to those skilled in the art.
- any one of the biguanides i.e. drugs having actions of stimulation of anaerobic glycolysis
- these, like metformin increase the sensitivity to insulin in peripheral tissues.
- metformin a substance that influences the sensitivity to insulin in peripheral tissues.
- These compounds also are involved in the inhibition of glucose absorption from the intestine, suppression of hepatic gluconeogenesis, and inhibition of fatty acid oxidation.
- Examples of other typical biguanides included in this application are phenformin, buformin etc.
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/784,288 US6451342B2 (en) | 2000-05-01 | 2001-02-15 | Core formulation comprised of troglitazone and a biguanide |
JP2003511800A JP2004536842A (en) | 2001-07-10 | 2001-07-10 | Core formulation containing troglitazone and biguanide |
CA002453782A CA2453782A1 (en) | 2001-07-10 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
EP01952549A EP1429740A4 (en) | 2001-07-10 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
MXPA04000181A MXPA04000181A (en) | 2001-07-10 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide. |
AU2001273290A AU2001273290B2 (en) | 2001-07-10 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
PCT/US2001/021616 WO2003005993A1 (en) | 2000-05-01 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20123300P | 2000-05-01 | 2000-05-01 | |
PCT/US2001/021616 WO2003005993A1 (en) | 2000-05-01 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003005993A1 true WO2003005993A1 (en) | 2003-01-23 |
Family
ID=26680526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2001/021616 WO2003005993A1 (en) | 2000-05-01 | 2001-07-10 | Core formulation comprising troglitazone and a biguanide |
Country Status (2)
Country | Link |
---|---|
US (1) | US6451342B2 (en) |
WO (1) | WO2003005993A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1429747A1 (en) * | 2001-07-10 | 2004-06-23 | Kos Life Sciences, Inc. | Core formulation comprising pioglitazone hydrochloride and a biguanide |
FR2850576A1 (en) * | 2003-02-05 | 2004-08-06 | Ethypharm Sa | Coated particles useful for making pharmaceutical or cosmetic compositions comprise one active ingredient in the core and another active ingredient in the coating |
AU2001273290B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | Core formulation comprising troglitazone and a biguanide |
Families Citing this family (21)
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US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
MY125516A (en) * | 1999-11-16 | 2006-08-30 | Smithkline Beecham Plc | Novel composition based on thiazolidinedione and metformin and use |
KR200249057Y1 (en) * | 2001-03-22 | 2001-10-19 | 김진환 | Sewage backflow integrated into the lid and base. Odor Prevention Device |
HUP0402328A2 (en) * | 2001-09-28 | 2005-02-28 | Sun Pharmaceutical Industries Limited | Pharmaceutical composition for treatment of diabetes mellitus |
WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
CA2499597C (en) | 2002-09-20 | 2012-01-17 | Unchalee Kositprapa | Multistage formulation containing a biguanide and thiazolidindione derivatives |
US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
US7959946B2 (en) | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
IN192749B (en) * | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
US20040109889A1 (en) * | 2002-12-04 | 2004-06-10 | Bunick Frank J. | Surface treatment composition for soft substrates |
GB0327216D0 (en) * | 2003-11-22 | 2003-12-24 | Nokia Corp | An interface for serial data communication |
WO2006082523A2 (en) * | 2005-01-25 | 2006-08-10 | Aurobindo Pharma Limited | Pharmaceutical sustained release composition of metformin |
US20070172525A1 (en) * | 2007-03-15 | 2007-07-26 | Ramesh Sesha | Anti-diabetic combinations |
US20080064701A1 (en) * | 2007-04-24 | 2008-03-13 | Ramesh Sesha | Anti-diabetic combinations |
US8551524B2 (en) * | 2008-03-14 | 2013-10-08 | Iycus, Llc | Anti-diabetic combinations |
US11110057B2 (en) * | 2010-04-07 | 2021-09-07 | Kemin Industries, Inc. | Micro particles for oral delivery in animals |
KR101876145B1 (en) * | 2017-11-21 | 2018-07-06 | 강은영 | Preparing method of carrier with controlled release rate of medicaments |
Citations (1)
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US6166042A (en) * | 1995-06-20 | 2000-12-26 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition |
-
2001
- 2001-02-15 US US09/784,288 patent/US6451342B2/en not_active Expired - Lifetime
- 2001-07-10 WO PCT/US2001/021616 patent/WO2003005993A1/en not_active Application Discontinuation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6166042A (en) * | 1995-06-20 | 2000-12-26 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1429747A1 (en) * | 2001-07-10 | 2004-06-23 | Kos Life Sciences, Inc. | Core formulation comprising pioglitazone hydrochloride and a biguanide |
AU2001273290B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | Core formulation comprising troglitazone and a biguanide |
EP1429747A4 (en) * | 2001-07-10 | 2005-01-05 | Kos Life Sciences Inc | Core formulation comprising pioglitazone hydrochloride and a biguanide |
FR2850576A1 (en) * | 2003-02-05 | 2004-08-06 | Ethypharm Sa | Coated particles useful for making pharmaceutical or cosmetic compositions comprise one active ingredient in the core and another active ingredient in the coating |
WO2004069135A2 (en) * | 2003-02-05 | 2004-08-19 | Ethypharm | Composition comprising a mixture of active principles, and method of preparation |
WO2004069135A3 (en) * | 2003-02-05 | 2004-10-28 | Ethypharm Sa | Composition comprising a mixture of active principles, and method of preparation |
AU2004210438B2 (en) * | 2003-02-05 | 2007-08-16 | Ethypharm | Composition comprising a mixture of active principles, and method of preparation |
EA010972B1 (en) * | 2003-02-05 | 2008-12-30 | Этифарм | Composition comprising a mixture of active principals, and method of preparation |
US7846460B2 (en) | 2003-02-05 | 2010-12-07 | Ethypharm | Composition comprising a mixture of active principles, and method of preparation |
NO341294B1 (en) * | 2003-02-05 | 2017-10-02 | Ethypharm Sa | Mixture comprising mixing active ingredients and a process for their preparation |
Also Published As
Publication number | Publication date |
---|---|
US20010034374A1 (en) | 2001-10-25 |
US6451342B2 (en) | 2002-09-17 |
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