WO2003004603A3 - Methods of modulating pharmacokinetics of oligonucleotides - Google Patents
Methods of modulating pharmacokinetics of oligonucleotides Download PDFInfo
- Publication number
- WO2003004603A3 WO2003004603A3 PCT/US2002/020940 US0220940W WO03004603A3 WO 2003004603 A3 WO2003004603 A3 WO 2003004603A3 US 0220940 W US0220940 W US 0220940W WO 03004603 A3 WO03004603 A3 WO 03004603A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oligonucleotides
- methods
- moe
- modified oligonucleotides
- modulating pharmacokinetics
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02742381A EP1409731A2 (en) | 2001-07-03 | 2002-07-01 | Methods of modulating pharmacokinetics of oligonucleotides |
CA002452310A CA2452310A1 (en) | 2001-07-03 | 2002-07-01 | Methods of modulating pharmacokinetics of oligonucleotides |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30268301P | 2001-07-03 | 2001-07-03 | |
US60/302,683 | 2001-07-03 | ||
US10/058,740 US6921812B1 (en) | 2001-07-03 | 2002-01-28 | Methods of modulating pharmacokinetics of oligonucleotides |
US10/058,740 | 2002-01-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2003004603A2 WO2003004603A2 (en) | 2003-01-16 |
WO2003004603A3 true WO2003004603A3 (en) | 2003-12-04 |
Family
ID=26737983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/020940 WO2003004603A2 (en) | 2001-07-03 | 2002-07-01 | Methods of modulating pharmacokinetics of oligonucleotides |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1409731A2 (en) |
CA (1) | CA2452310A1 (en) |
WO (1) | WO2003004603A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7947817B2 (en) * | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
FR2860143B1 (en) * | 2003-09-26 | 2008-06-27 | Oreal | COSMETIC COMPOSITION COMPRISING A SEQUENCE POLYMER AND A NON-VOLATILE SILICONE OIL |
US7928207B2 (en) * | 2004-06-28 | 2011-04-19 | Roche Molecular Systems, Inc | Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides |
US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
TW201422633A (en) | 2012-08-31 | 2014-06-16 | Kyowa Hakko Kirin Co Ltd | Oligonucleotide |
JP6586078B2 (en) * | 2014-03-03 | 2019-10-02 | 協和キリン株式会社 | Oligonucleotides having unnatural nucleotides at the 5 'end |
US11518780B2 (en) | 2019-07-31 | 2022-12-06 | Shiyue Fang | Sensitive oligonucleotide synthesis using sulfur-based functions as protecting groups and linkers |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6147200A (en) * | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
US6239272B1 (en) * | 1995-04-20 | 2001-05-29 | Ribozyme Pharmaceutical | 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids |
-
2002
- 2002-07-01 CA CA002452310A patent/CA2452310A1/en not_active Abandoned
- 2002-07-01 EP EP02742381A patent/EP1409731A2/en not_active Withdrawn
- 2002-07-01 WO PCT/US2002/020940 patent/WO2003004603A2/en not_active Application Discontinuation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6239272B1 (en) * | 1995-04-20 | 2001-05-29 | Ribozyme Pharmaceutical | 2'-O-alkylthioalkyl and 2'-c-alkylthioalkyl-containing nucleic acids |
US6147200A (en) * | 1999-08-19 | 2000-11-14 | Isis Pharmaceuticals, Inc. | 2'-O-acetamido modified monomers and oligomers |
Non-Patent Citations (1)
Title |
---|
PRAKASH T. ET AL.: "2'-O-(2-(methylthio)ethyl)-modified oligonucleotide: An analogue of 2'-O-(2-(methoxy)ethyl)-modified oligonucleotide with improved protein binding properties and high binding affinity to target RNA", BIOCHEMISTRY, vol. 41, September 2002 (2002-09-01), pages 11642 - 11648, XP002962878 * |
Also Published As
Publication number | Publication date |
---|---|
WO2003004603A2 (en) | 2003-01-16 |
CA2452310A1 (en) | 2003-01-16 |
EP1409731A2 (en) | 2004-04-21 |
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