WO2003004536A3 - Method for producing cross-linked polysaccharides and use thereof as stationary phases in separation processes - Google Patents

Method for producing cross-linked polysaccharides and use thereof as stationary phases in separation processes Download PDF

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Publication number
WO2003004536A3
WO2003004536A3 PCT/EP2002/007236 EP0207236W WO03004536A3 WO 2003004536 A3 WO2003004536 A3 WO 2003004536A3 EP 0207236 W EP0207236 W EP 0207236W WO 03004536 A3 WO03004536 A3 WO 03004536A3
Authority
WO
WIPO (PCT)
Prior art keywords
cross
linking
separation processes
stationary phases
producing cross
Prior art date
Application number
PCT/EP2002/007236
Other languages
German (de)
French (fr)
Other versions
WO2003004536A2 (en
Inventor
Joachim Teller
Jutta Nagel
Michael Frank
Fritz Westphal
Original Assignee
Pyranomod Adsorbertechnologie
Joachim Teller
Jutta Nagel
Michael Frank
Fritz Westphal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pyranomod Adsorbertechnologie, Joachim Teller, Jutta Nagel, Michael Frank, Fritz Westphal filed Critical Pyranomod Adsorbertechnologie
Publication of WO2003004536A2 publication Critical patent/WO2003004536A2/en
Publication of WO2003004536A3 publication Critical patent/WO2003004536A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/262—Synthetic macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. obtained by polycondensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/26—Synthetic macromolecular compounds
    • B01J20/265—Synthetic macromolecular compounds modified or post-treated polymers
    • B01J20/267—Cross-linked polymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28002—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their physical properties
    • B01J20/28009—Magnetic properties
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/281—Sorbents specially adapted for preparative, analytical or investigative chromatography
    • B01J20/282—Porous sorbents
    • B01J20/285—Porous sorbents based on polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0036—Galactans; Derivatives thereof
    • C08B37/0039—Agar; Agarose, i.e. D-galactose, 3,6-anhydro-D-galactose, methylated, sulfated, e.g. from the red algae Gelidium and Gracilaria; Agaropectin; Derivatives thereof, e.g. Sepharose, i.e. crosslinked agarose
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00—Aspects relating to sorbent materials
    • B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/54—Sorbents specially adapted for analytical or investigative chromatography

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Compositions Of Macromolecular Compounds (AREA)

Abstract

The invention relates to a method for producing cross-linked particles which are used as stationary phases in separation processes. The inventive cross-linking strategy is based on a structured primary cross-linking with reactive nanoparticles and the use of a further molecular cross-linking agent. For areas of application which require inter alia a visualization or the magnetic mobility of cross-linked polysaccharide substances, corresponding coloured, fluorescent or magnetizable nanoparticles can be used as particular cross-linking agents. Said cross-linking is, however, of particular interest with regard to the production of spherical particles having a diameter of between 1 νm and 1 mm and the use of agarose as a matrix material.
PCT/EP2002/007236 2001-07-03 2002-07-01 Method for producing cross-linked polysaccharides and use thereof as stationary phases in separation processes WO2003004536A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10132131.7 2001-07-03
DE10132131A DE10132131A1 (en) 2001-07-03 2001-07-03 Process for the production of cross-linked polysaccharides and their use as stationary phases in separation processes

Publications (2)

Publication Number Publication Date
WO2003004536A2 WO2003004536A2 (en) 2003-01-16
WO2003004536A3 true WO2003004536A3 (en) 2003-03-20

Family

ID=7690397

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/007236 WO2003004536A2 (en) 2001-07-03 2002-07-01 Method for producing cross-linked polysaccharides and use thereof as stationary phases in separation processes

Country Status (2)

Country Link
DE (1) DE10132131A1 (en)
WO (1) WO2003004536A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080283792A1 (en) * 2005-10-28 2008-11-20 Ge Healthcare Bio-Sciences Ab Separation Medium with Various Functionalities
CN102335595B (en) * 2010-07-20 2013-07-10 华东理工大学 Novel preparation method of monolithic column stationary phase having gradient distribution

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2714671A1 (en) * 1994-01-05 1995-07-07 Conservatoire Nal Arts Metiers Novel polysaccharide derivatives and their use for the preparation of chiral stationary phases useful for the separation of isomers of chemical compounds.
US5587467A (en) * 1993-06-22 1996-12-24 Daicel Chemical Industries, Ltd. Separating agent for optical isomers and process for producing the same
EP1036763A1 (en) * 1999-02-12 2000-09-20 micromod Partikeltechnologie GmbH Process for the preparation of coloured and fluorescent polysilicic acid particles

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5587467A (en) * 1993-06-22 1996-12-24 Daicel Chemical Industries, Ltd. Separating agent for optical isomers and process for producing the same
FR2714671A1 (en) * 1994-01-05 1995-07-07 Conservatoire Nal Arts Metiers Novel polysaccharide derivatives and their use for the preparation of chiral stationary phases useful for the separation of isomers of chemical compounds.
EP1036763A1 (en) * 1999-02-12 2000-09-20 micromod Partikeltechnologie GmbH Process for the preparation of coloured and fluorescent polysilicic acid particles

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ARSHADY R: "MICROSPHERES AND MICROCAPSULES: A SURVEY OF MANUFACTURING TECHNIQUES. PART 1: SUSPENSION CROSS-LINKING", POLYMER ENGINEERING AND SCIENCE, BROOKFIELD CENTER, US, vol. 29, no. 24, December 1989 (1989-12-01), pages 1746 - 1758, XP000826592 *
CORDULA GRÜTTNER ET AL.: "New types of silica-fortified magnetic nanoparticles as tools for molecular biology applications", JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, vol. 194, no. 1-3, 1 April 1999 (1999-04-01), pages 8 - 15, XP002223542 *

Also Published As

Publication number Publication date
DE10132131A1 (en) 2003-12-04
WO2003004536A2 (en) 2003-01-16

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