WO2003002529A3 - Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone - Google Patents

Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone Download PDF

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Publication number
WO2003002529A3
WO2003002529A3 PCT/US2002/022085 US0222085W WO03002529A3 WO 2003002529 A3 WO2003002529 A3 WO 2003002529A3 US 0222085 W US0222085 W US 0222085W WO 03002529 A3 WO03002529 A3 WO 03002529A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymorphs
quinolinone
tetrazol
butoxy
dihydro
Prior art date
Application number
PCT/US2002/022085
Other languages
French (fr)
Other versions
WO2003002529A2 (en
Inventor
Grayson Walker Stowell
Robert R Whittle
Original Assignee
Aaipharma Inc
Grayson Walker Stowell
Robert R Whittle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/896,184 external-priority patent/US6531603B1/en
Priority claimed from US09/896,800 external-priority patent/US6596871B2/en
Priority claimed from US09/896,185 external-priority patent/US20030045548A1/en
Application filed by Aaipharma Inc, Grayson Walker Stowell, Robert R Whittle filed Critical Aaipharma Inc
Priority to AU2002322456A priority Critical patent/AU2002322456A1/en
Publication of WO2003002529A2 publication Critical patent/WO2003002529A2/en
Publication of WO2003002529A3 publication Critical patent/WO2003002529A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Polymorphs Form B, Form C, and amorphous of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone, commonly known as cilostazol, have been identified. These polymorphs may be formed in pure form, in combination with each other, in combination with other polymorphs of cilostazol, or together with other pharmaceutical agents. Processes for preparing these polymorphs, and combinations of these polymorphs, as well as methods of use and unit dosages of these polymorphic forms, and their combinations, are described.
PCT/US2002/022085 2001-06-29 2002-06-28 Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone WO2003002529A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002322456A AU2002322456A1 (en) 2001-06-29 2002-06-28 Polymorphic forms of 6-(4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy)-3, 4-dihydro-2(1h)-quinolinone

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US09/896,184 US6531603B1 (en) 2001-06-29 2001-06-29 Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US09/896,800 US6596871B2 (en) 2001-06-29 2001-06-29 Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetraol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
US09/896,185 2001-06-29
US09/896,184 2001-06-29
US09/896,185 US20030045548A1 (en) 2001-06-29 2001-06-29 Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-YL)butoxy]-3,4-dihydro-2(1H)-quinolinone
US09/896,800 2001-06-29

Publications (2)

Publication Number Publication Date
WO2003002529A2 WO2003002529A2 (en) 2003-01-09
WO2003002529A3 true WO2003002529A3 (en) 2003-05-08

Family

ID=27420565

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022085 WO2003002529A2 (en) 2001-06-29 2002-06-28 Polymorphic forms of 6-[4-(1-cyclohexyl-1h-tetrazol-5-yl)butoxy]-3, 4-dihydro-2(1h)-quinolinone

Country Status (2)

Country Link
AU (1) AU2002322456A1 (en)
WO (1) WO2003002529A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277479A (en) * 1978-09-01 1981-07-07 Otsuka Pharmaceutical Co., Ltd. Tetrazolylalkoxycarbostyril derivatives and pharmaceutical compositions containing them
US4728653A (en) * 1984-05-29 1988-03-01 Pfizer Inc. 6-heteroaryl quinolone inotropic agents
US6388080B1 (en) * 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4277479A (en) * 1978-09-01 1981-07-07 Otsuka Pharmaceutical Co., Ltd. Tetrazolylalkoxycarbostyril derivatives and pharmaceutical compositions containing them
US4728653A (en) * 1984-05-29 1988-03-01 Pfizer Inc. 6-heteroaryl quinolone inotropic agents
US6388080B1 (en) * 2001-06-29 2002-05-14 Grayson Walker Stowell Polymorphic forms of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone

Also Published As

Publication number Publication date
AU2002322456A1 (en) 2003-03-03
WO2003002529A2 (en) 2003-01-09

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