WO2003000734A3 - Ion channel modulators - Google Patents

Ion channel modulators Download PDF

Info

Publication number
WO2003000734A3
WO2003000734A3 PCT/GB2002/002919 GB0202919W WO03000734A3 WO 2003000734 A3 WO2003000734 A3 WO 2003000734A3 GB 0202919 W GB0202919 W GB 0202919W WO 03000734 A3 WO03000734 A3 WO 03000734A3
Authority
WO
WIPO (PCT)
Prior art keywords
ion channel
channel modulators
relates
modulators
haematophagous arthropods
Prior art date
Application number
PCT/GB2002/002919
Other languages
French (fr)
Other versions
WO2003000734A2 (en
Inventor
Patricia Anne Nuttall
Miles Andrew Nunn
Peter Takac
Olga Pechanova
Petra Rajska
Milan Kozanek
Norbert Vrbjar
Maria Kazimirova
Milan Labuda
Original Assignee
Evolutec Ltd
Patricia Anne Nuttall
Miles Andrew Nunn
Peter Takac
Olga Pechanova
Petra Rajska
Milan Kozanek
Norbert Vrbjar
Maria Kazimirova
Milan Labuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolutec Ltd, Patricia Anne Nuttall, Miles Andrew Nunn, Peter Takac, Olga Pechanova, Petra Rajska, Milan Kozanek, Norbert Vrbjar, Maria Kazimirova, Milan Labuda filed Critical Evolutec Ltd
Priority to EP02748981A priority Critical patent/EP1401868A2/en
Publication of WO2003000734A2 publication Critical patent/WO2003000734A2/en
Publication of WO2003000734A3 publication Critical patent/WO2003000734A3/en
Priority to US10/743,280 priority patent/US20050090437A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8135—Kazal type inhibitors, e.g. pancreatic secretory inhibitor, ovomucoid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The present invention relates to ion channel modulators. In particular, the invention relates to ion channel modulators that are derived from haematophagous arthropods. The invention also relates to the use of ion channel modulators from haematophagous arthropods in the treatment and prevention of certain diseases and conditions in mammals, including humans.
PCT/GB2002/002919 2001-06-22 2002-06-21 Ion channel modulators WO2003000734A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02748981A EP1401868A2 (en) 2001-06-22 2002-06-21 Ion channel modulators
US10/743,280 US20050090437A1 (en) 2001-06-22 2003-12-22 Ion channel modulators

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0115363A GB0115363D0 (en) 2001-06-22 2001-06-22 Ion channel modulators
GB0115363.4 2001-06-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/743,280 Continuation US20050090437A1 (en) 2001-06-22 2003-12-22 Ion channel modulators

Publications (2)

Publication Number Publication Date
WO2003000734A2 WO2003000734A2 (en) 2003-01-03
WO2003000734A3 true WO2003000734A3 (en) 2003-09-12

Family

ID=9917206

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/002919 WO2003000734A2 (en) 2001-06-22 2002-06-21 Ion channel modulators

Country Status (3)

Country Link
EP (1) EP1401868A2 (en)
GB (1) GB0115363D0 (en)
WO (1) WO2003000734A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH709276A2 (en) 2014-02-17 2015-08-28 Foboha Gmbh Processing and injection molding.

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
"The covalent structure of the elastase inhibitor from anemonia sulcata- 'a non-classical' Kazal-type protein.", BIOL. CHEM. HOPPE-SEYLER, vol. 368, 1987, pages 1297 - 1304 *
CUPP M.S. ET AL.: "Vasodilative activity in blak fly salivary glands.", AMERICAN JOURNAL TROPICAL MEDICINE HYGIENE, vol. 50, no. 2, - 1994, pages 241 - 246, XP002910117 *
DATABASE EMBL [online] 1 August 1990 (1990-08-01), XP002239343, retrieved from EBI Database accession no. P16895 *
DATABASE EMBL [online] 1 May 2000 (2000-05-01), XP002239344, retrieved from EBI Database accession no. Q9U512 *
HAWKINS T.E. ET AL.: "Calcium signalling and annexins.", CELL BIOCHEMISTRY AND BIOPHYSICS., vol. 33, no. 3, 2000, pages 275 - 296, XP009009969 *

Also Published As

Publication number Publication date
WO2003000734A2 (en) 2003-01-03
GB0115363D0 (en) 2001-08-15
EP1401868A2 (en) 2004-03-31

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