WO2003000403A3 - Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese - Google Patents

Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese Download PDF

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Publication number
WO2003000403A3
WO2003000403A3 PCT/DE2002/001556 DE0201556W WO03000403A3 WO 2003000403 A3 WO2003000403 A3 WO 2003000403A3 DE 0201556 W DE0201556 W DE 0201556W WO 03000403 A3 WO03000403 A3 WO 03000403A3
Authority
WO
WIPO (PCT)
Prior art keywords
synthesis
pins
reagents
holder
solid phase
Prior art date
Application number
PCT/DE2002/001556
Other languages
English (en)
French (fr)
Other versions
WO2003000403A2 (de
Inventor
Oliver Johannes Kreuzer
Carsten Hessenius
Carsten Groetzinger
Volker Johannson
Ralph-Th Roeder
Original Assignee
Peptides & Elephants Gmbh
Oliver Johannes Kreuzer
Carsten Hessenius
Carsten Groetzinger
Volker Johannson
Ralph-Th Roeder
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peptides & Elephants Gmbh, Oliver Johannes Kreuzer, Carsten Hessenius, Carsten Groetzinger, Volker Johannson, Ralph-Th Roeder filed Critical Peptides & Elephants Gmbh
Priority to DE50208265T priority Critical patent/DE50208265D1/de
Priority to US10/466,709 priority patent/US7678335B2/en
Priority to EP02740299A priority patent/EP1401569B1/de
Priority to AU2002315664A priority patent/AU2002315664A1/en
Publication of WO2003000403A2 publication Critical patent/WO2003000403A2/de
Publication of WO2003000403A3 publication Critical patent/WO2003000403A3/de

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0265—Drop counters; Drop formers using valves to interrupt or meter fluid flow, e.g. using solenoids or metering valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00319—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks the blocks being mounted in stacked arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00405—Sliding valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00452—Means for the recovery of reactants or products
    • B01J2219/00454—Means for the recovery of reactants or products by chemical cleavage from the solid support
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/005—Beads
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/0059—Sequential processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00682—Manual means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00689—Automatic using computers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00686—Automatic
    • B01J2219/00691—Automatic using robots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/14—Solid phase synthesis, i.e. wherein one or more library building blocks are bound to a solid support during library creation; Particular methods of cleavage from the solid support
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Surgical Instruments (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Revetment (AREA)

Abstract

Die Erfindung betrifft eine Vorrichtung zur gleichzeitigen multiplen und hochparallelen Synthese von Verbindungen auf der Basis der Festphasensynthese, insbesondere für die Peptidsynthese. Um die mehrfachen, zeit - und kostenintensiven Spülvorgänge, die bisher bei der Festphasensynthese nach der Reagenzienverteilung und einem Wechsel der Reagenzien notwendig waren, zu vermeiden, wird eine verbesserte Vorrichtung für eine voll automatisierte Synthese und abschliessende Abspaltung der synthetisierten Verbindungen vorgeschlagen, die für die Synthesebausteine jeweils separate Synthesestifte 11 mit einem Reagenzienreservoir 20; 21 und individueller Dosierung vorsieht. Die Synthesestifte 11 werden in einer gesonderten Halterung 4 bereitgestellt und aus dieser Halterung 4 von Greifarm 2 des Syntheseautomaten 1 aufgenommen. Für das kontaminationsfreie Aufsetzen der Synthesestifte 11 und Zudosieren der Reagenzien auf die Fest- oder Flüssigphase sind die Reaktionskammern 9 der Syntheseplatten 5 öffnungsseitig durch ein permeables Material 25 verschlossen (abgedeckt). Ferner ist unterhalb des Ventilblockes 6 eine Probenplatte 27 für die Aufnahme der nach Abspaltreaktion gelösten Proben angeordnet.
PCT/DE2002/001556 2001-06-25 2002-04-25 Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese WO2003000403A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE50208265T DE50208265D1 (de) 2001-06-25 2002-04-25 Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese
US10/466,709 US7678335B2 (en) 2001-06-25 2002-04-25 Device for simultaneous multiple and high parallel synthesis
EP02740299A EP1401569B1 (de) 2001-06-25 2002-04-25 Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese
AU2002315664A AU2002315664A1 (en) 2001-06-25 2002-04-25 Device for simultaneous multiple and high parallel synthesis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131088A DE10131088B4 (de) 2001-06-25 2001-06-25 Vorrichtung zur gleichzeitigen multiplen und parallelen Synthese von Peptiden
DE10131088.9 2001-06-25

Publications (2)

Publication Number Publication Date
WO2003000403A2 WO2003000403A2 (de) 2003-01-03
WO2003000403A3 true WO2003000403A3 (de) 2003-04-24

Family

ID=7689699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/001556 WO2003000403A2 (de) 2001-06-25 2002-04-25 Vorrichtung zur gleichzeitigen multiplen und hochparallelen synthese

Country Status (6)

Country Link
US (1) US7678335B2 (de)
EP (1) EP1401569B1 (de)
AT (1) ATE340641T1 (de)
AU (1) AU2002315664A1 (de)
DE (2) DE10131088B4 (de)
WO (1) WO2003000403A2 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10229376B4 (de) * 2002-06-26 2007-06-21 Peptides&Elephants Gmbh Vorrichtung zur hochparallelen mikrochemischen Synthese
DE10327380A1 (de) * 2003-06-18 2005-01-13 Eppendorf Ag System zum Dosieren von Probenflüssigkeit
EP2506040A1 (de) 2011-04-01 2012-10-03 Université Catholique De Louvain Verfahren und Vorrichtung zur Charakterisierung physikalischer Eigenschaften eines Zielvolumens durch elektromagnetische Inspektion
DE102020100797A1 (de) 2019-01-15 2020-07-16 Oliver Johannes Kreuzer Verfahren zur Festphasenpeptidsynthese und Vorrichtung
CN113713748B (zh) * 2021-08-16 2022-10-21 通用生物(安徽)股份有限公司 一种药用核酸用自动配液合成仪

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1686188A (en) * 1926-02-26 1928-10-02 Tipton Edna Sibley Perfume container and dispenser
EP0355266A2 (de) * 1988-04-29 1990-02-28 Millipore Corporation Apparat zur Durchführung von sich wiederholenden chemischen Reaktionen
US5551487A (en) * 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
EP1088585A2 (de) * 1997-02-17 2001-04-04 Gesellschaft für biotechnologische Forschung mbH (GBF) Automatisiertes simultanes chemisches Syntheseverfahren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260028A (en) * 1988-02-22 1993-11-09 Astle Thomas W Method and apparatus for effecting solid phase extraction
JPH06220084A (ja) * 1993-01-23 1994-08-09 Shimadzu Corp ペプチド合成装置

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1686188A (en) * 1926-02-26 1928-10-02 Tipton Edna Sibley Perfume container and dispenser
EP0355266A2 (de) * 1988-04-29 1990-02-28 Millipore Corporation Apparat zur Durchführung von sich wiederholenden chemischen Reaktionen
US5551487A (en) * 1995-03-10 1996-09-03 Hewlett-Packard Company Micro-dispenser for preparing assay plates
EP1088585A2 (de) * 1997-02-17 2001-04-04 Gesellschaft für biotechnologische Forschung mbH (GBF) Automatisiertes simultanes chemisches Syntheseverfahren

Also Published As

Publication number Publication date
DE50208265D1 (de) 2006-11-09
US7678335B2 (en) 2010-03-16
AU2002315664A1 (en) 2003-01-08
WO2003000403A2 (de) 2003-01-03
EP1401569A2 (de) 2004-03-31
EP1401569B1 (de) 2006-09-27
DE10131088A1 (de) 2003-01-23
US20040244867A1 (en) 2004-12-09
DE10131088B4 (de) 2005-01-13
ATE340641T1 (de) 2006-10-15

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