WO2003000296A3 - Treatment and diagnostic of b cell chronic lymphocytic leukaemia - Google Patents

Treatment and diagnostic of b cell chronic lymphocytic leukaemia Download PDF

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Publication number
WO2003000296A3
WO2003000296A3 PCT/GB2002/002857 GB0202857W WO03000296A3 WO 2003000296 A3 WO2003000296 A3 WO 2003000296A3 GB 0202857 W GB0202857 W GB 0202857W WO 03000296 A3 WO03000296 A3 WO 03000296A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
chronic lymphocytic
diagnostic
cell chronic
lymphocytic leukaemia
Prior art date
Application number
PCT/GB2002/002857
Other languages
French (fr)
Other versions
WO2003000296A2 (en
Inventor
Youming Zhang
Miriam Moffatt
William Cookson
Original Assignee
Isis Innovations Ltd
Youming Zhang
Miriam Moffatt
William Cookson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Innovations Ltd, Youming Zhang, Miriam Moffatt, William Cookson filed Critical Isis Innovations Ltd
Priority to AU2002310646A priority Critical patent/AU2002310646A1/en
Publication of WO2003000296A2 publication Critical patent/WO2003000296A2/en
Publication of WO2003000296A3 publication Critical patent/WO2003000296A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The present invention relates to materials and methods for the diagnosis and treatment of B-cell chronic lymphocytic leukaemia (BCLL). The present invention relates to a method of treating BCLL in an individual comprising modulating the expression of the CLLD8 and/or the NY-REN-34 gene.
PCT/GB2002/002857 2001-06-21 2002-06-21 Treatment and diagnostic of b cell chronic lymphocytic leukaemia WO2003000296A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002310646A AU2002310646A1 (en) 2001-06-21 2002-06-21 Treatment and diagnostic of b cell chronic lymphocytic leukaemia

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0115211.5 2001-06-21
GBGB0115211.5A GB0115211D0 (en) 2001-06-21 2001-06-21 B-cell chronic lymphocytic leukemia

Publications (2)

Publication Number Publication Date
WO2003000296A2 WO2003000296A2 (en) 2003-01-03
WO2003000296A3 true WO2003000296A3 (en) 2003-06-05

Family

ID=9917097

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/002857 WO2003000296A2 (en) 2001-06-21 2002-06-21 Treatment and diagnostic of b cell chronic lymphocytic leukaemia

Country Status (3)

Country Link
AU (1) AU2002310646A1 (en)
GB (1) GB0115211D0 (en)
WO (1) WO2003000296A2 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000727A2 (en) * 2001-06-21 2003-01-03 Isis Innovation Limited Atopy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000727A2 (en) * 2001-06-21 2003-01-03 Isis Innovation Limited Atopy

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHESON ET AL: "New drugs for the treatment of chronic lymphocytic leukemia", REVIEWS IN CLINICAL AND EXPERIMENTAL HEMATOLOGY, FORUM SERVICE EDITORE, GENOVA, IT, 2000, pages 145 - 166, XP002226646, ISSN: 1127-0020 *
MABUCHI HIDEAKI ET AL: "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.", CANCER RESEARCH, vol. 61, no. 7, 1 April 2001 (2001-04-01), pages 2870 - 2877, XP002233928, ISSN: 0008-5472 *
SCANLAN M J ET AL: "ANTIGENS RECOGNIZED BY AUTOLOGOUS ANTIBODY IN PATIENTS WITH RENAL-CELL CARCINOMA", INTERNATIONAL JOURNAL OF CANCER, NEW YORK, NY, US, vol. 83, no. 4, 12 November 1999 (1999-11-12), pages 456 - 464, XP000867569, ISSN: 0020-7136 *

Also Published As

Publication number Publication date
AU2002310646A1 (en) 2003-01-08
WO2003000296A2 (en) 2003-01-03
GB0115211D0 (en) 2001-08-15

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