WO2002099379A3 - Breast homing peptides and methods of identifying same using aminopeptidase p - Google Patents
Breast homing peptides and methods of identifying same using aminopeptidase p Download PDFInfo
- Publication number
- WO2002099379A3 WO2002099379A3 PCT/US2002/016462 US0216462W WO02099379A3 WO 2002099379 A3 WO2002099379 A3 WO 2002099379A3 US 0216462 W US0216462 W US 0216462W WO 02099379 A3 WO02099379 A3 WO 02099379A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- aminopeptidase
- methods
- breast
- homing peptides
- identifying same
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
Abstract
The present invention provides a method of directing a moiety to breast vasculature in a subject by administering to the subject a conjugate which contains a moiety linked to a homing molecule that selectively homes to breast vasculature, whereby the moiety is directed to breast vasculature. In one embodiment, the homing molecule is a peptide containing the amino acid sequence PGPEGAG (SEQ ID NO: 1), or a peptidomimetic thereof.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002310106A AU2002310106A1 (en) | 2001-06-01 | 2002-05-21 | Breast homing peptides and methods of identifying same using aminopeptidase p |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87234201A | 2001-06-01 | 2001-06-01 | |
US09/872,342 | 2001-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002099379A2 WO2002099379A2 (en) | 2002-12-12 |
WO2002099379A3 true WO2002099379A3 (en) | 2003-07-03 |
Family
ID=25359386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/016462 WO2002099379A2 (en) | 2001-06-01 | 2002-05-21 | Breast homing peptides and methods of identifying same using aminopeptidase p |
Country Status (2)
Country | Link |
---|---|
AU (1) | AU2002310106A1 (en) |
WO (1) | WO2002099379A2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004104575A2 (en) * | 2003-05-23 | 2004-12-02 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with x-prolyl aminopeptidase 2 (xpnpep2) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0478101A2 (en) * | 1990-09-24 | 1992-04-01 | W.R. Grace & Co.-Conn. | Therapeutic use of peptides having thrombospondin-like activity |
WO1993022338A1 (en) * | 1992-05-05 | 1993-11-11 | Rijksuniversiteit Leiden | Peptides of human papilloma virus for use in human t cell response inducing compositions |
US5641497A (en) * | 1992-05-22 | 1997-06-24 | Children's Hospital Of Philadelphia | Gastrointestinal defensins, cDNA sequences and method for the production and use thereof |
-
2002
- 2002-05-21 WO PCT/US2002/016462 patent/WO2002099379A2/en not_active Application Discontinuation
- 2002-05-21 AU AU2002310106A patent/AU2002310106A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0478101A2 (en) * | 1990-09-24 | 1992-04-01 | W.R. Grace & Co.-Conn. | Therapeutic use of peptides having thrombospondin-like activity |
WO1993022338A1 (en) * | 1992-05-05 | 1993-11-11 | Rijksuniversiteit Leiden | Peptides of human papilloma virus for use in human t cell response inducing compositions |
US5641497A (en) * | 1992-05-22 | 1997-06-24 | Children's Hospital Of Philadelphia | Gastrointestinal defensins, cDNA sequences and method for the production and use thereof |
Non-Patent Citations (3)
Title |
---|
FINK J.K. ET AL.: "Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence and developmental- and tissue-specific expression", GENOMICS, vol. 35, no. 3, 1 August 1996 (1996-08-01), pages 577 - 585, XP002960780 * |
REDENBACH M. ET AL.: "A set of ordered cosmids and a detailed genetic and physical map for the 8Mb streptomyces coelicolor A3(2) chromosome", MOL. MICROBIOL., vol. 21, no. 1, July 1996 (1996-07-01), pages 77 - 96, XP002907946 * |
RUOSLAHTI E.: "Targeting tumor vasculature with homing peptides from phage display", SEMIN. CANCER BIOL., vol. 10, no. 6, December 2000 (2000-12-01), pages 435 - 442, XP002963317 * |
Also Published As
Publication number | Publication date |
---|---|
AU2002310106A1 (en) | 2002-12-16 |
WO2002099379A2 (en) | 2002-12-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2360176A3 (en) | Hybrid and tandem expression of neisserial derived proteins | |
EP2368907A3 (en) | Anti-Abeta antibodies and their use | |
ATE368053T1 (en) | ANTIMICROBIAL PEPTIDES | |
MXPA04000597A (en) | Novel peptides of the respiratory syncytial virus (rsv) g protein and their use in a vaccine. | |
AU2002217010A1 (en) | Peptides, the production and use thereof for binding immunoglobulins | |
WO2005051998A3 (en) | Antibodies binding to a c-terminal fragment of apolipoprotein e | |
WO2006101782A3 (en) | A cysteine-containing peptide tag for site-specific conjugation of proteins | |
WO2002072616A3 (en) | Transfection complexes | |
WO2007029262A3 (en) | Compositions and methods using same for the detection of viruses | |
WO2002008426A3 (en) | Fh-binding protein of streptococcus pneumoniae | |
EP1548107A4 (en) | Chromoprotein and fluoroproteins | |
WO2001027136A3 (en) | Peptides which stimulate the immune response and tissue regeneration | |
IL142709A0 (en) | Novel amino acid sequences, dna encoding the amino acid sequences, antibodies directed against such sequences and the different uses thereof | |
WO2006029343A3 (en) | Peptides that selectively home to heart vasculature and related conjugates and methods | |
WO2005039495A3 (en) | Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies | |
WO2002099379A3 (en) | Breast homing peptides and methods of identifying same using aminopeptidase p | |
WO2005041882A3 (en) | Molecules that selectively home to vasculature of premalignant or malignant lesions of the pancreas and other organs | |
PL343554A1 (en) | Novel peptide diagnostic reagent and kit for detection of rickettsiosis | |
HK1031664A1 (en) | Use of an organ-specific nutritional composition | |
EP1557466A4 (en) | Tumor antigen protein and utilization thereof | |
WO2002030975A3 (en) | Antifungal peptides | |
WO2004000870A3 (en) | Two synthetic peptides for treatment and prevention of cancers | |
NZ508812A (en) | Peptides for the prevention or treatment of HIV | |
WO2003064446A3 (en) | Plasma protein-binding peptides from bacterial curli | |
WO2003070770A3 (en) | Engineered human kunitz-type protease inhibitor |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AU CA JP |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
122 | Ep: pct application non-entry in european phase | ||
NENP | Non-entry into the national phase |
Ref country code: JP |
|
WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |