WO2002096944A3 - Nouveaux canaux potassiques heterotetrameres et utilisations de ces derniers - Google Patents

Nouveaux canaux potassiques heterotetrameres et utilisations de ces derniers Download PDF

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Publication number
WO2002096944A3
WO2002096944A3 PCT/EP2002/006082 EP0206082W WO02096944A3 WO 2002096944 A3 WO2002096944 A3 WO 2002096944A3 EP 0206082 W EP0206082 W EP 0206082W WO 02096944 A3 WO02096944 A3 WO 02096944A3
Authority
WO
WIPO (PCT)
Prior art keywords
heterotetrameric
new
potassium channels
present
potassium
Prior art date
Application number
PCT/EP2002/006082
Other languages
English (en)
Other versions
WO2002096944A2 (fr
Inventor
Dirk J Snyders
Natacha Ottschytsch
Adam Raes
Hoorick Diane Van
Original Assignee
Vlaams Interuniv Inst Biotech
Dirk J Snyders
Natacha Ottschytsch
Adam Raes
Hoorick Diane Van
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech, Dirk J Snyders, Natacha Ottschytsch, Adam Raes, Hoorick Diane Van filed Critical Vlaams Interuniv Inst Biotech
Priority to AU2002314132A priority Critical patent/AU2002314132A1/en
Publication of WO2002096944A2 publication Critical patent/WO2002096944A2/fr
Publication of WO2002096944A3 publication Critical patent/WO2002096944A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La présente invention concerne de nouveaux canaux potassiques hétérotétramères dépendant d'un potentiel d'action, comprenant des sous-unités de canaux potassiques Kv2.1, Kv3.1, Kv5.1, Kv6.3, Kv10.1 ou Kv11.1. L'invention traite de l'utilisation directe ou indirecte de ces derniers pour diagnostiquer, prévenir et/ou traiter les troubles d'excitabilité. De plus, la présente invention traite de la séquence de l'ADNc de la sous-unité du canal potassique Kv10.1.
PCT/EP2002/006082 2001-05-31 2002-05-31 Nouveaux canaux potassiques heterotetrameres et utilisations de ces derniers WO2002096944A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002314132A AU2002314132A1 (en) 2001-05-31 2002-05-31 New heterotetrameric potassium channels and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202060 2001-05-31
EP01202060.8 2001-05-31

Publications (2)

Publication Number Publication Date
WO2002096944A2 WO2002096944A2 (fr) 2002-12-05
WO2002096944A3 true WO2002096944A3 (fr) 2003-11-20

Family

ID=8180398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006082 WO2002096944A2 (fr) 2001-05-31 2002-05-31 Nouveaux canaux potassiques heterotetrameres et utilisations de ces derniers

Country Status (2)

Country Link
AU (1) AU2002314132A1 (fr)
WO (1) WO2002096944A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670335A (en) * 1993-08-06 1997-09-23 The Regents Of The University Of California Mammalian inward rectifier potasssium channel cDNAs, host cells expressing them, and screening assays using such cells
WO1998004521A1 (fr) * 1996-07-26 1998-02-05 Icagen, Inc. Inhibiteurs du canal de potassium

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5670335A (en) * 1993-08-06 1997-09-23 The Regents Of The University Of California Mammalian inward rectifier potasssium channel cDNAs, host cells expressing them, and screening assays using such cells
WO1998004521A1 (fr) * 1996-07-26 1998-02-05 Icagen, Inc. Inhibiteurs du canal de potassium

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 16 March 2000 (2000-03-16), "Homo sapiens chromosome UNK clone RP11-804P20", XP002181998 *
DATABASE EMBL 24 January 2001 (2001-01-24), "602286371f1 NIH_MGC_95 Homo sapiens cDNA clone IMAGE:4375480 5' mRNA sequence", XP002181999 *
DATABASE GENBANK [online] 30 May 2001 (2001-05-30), XP002223177, retrieved from NCBI *
DWORAKOWSKA BEATA ET AL: "Ion channels-related diseases.", ACTA BIOCHIMICA POLONICA, vol. 47, no. 3, 2000, pages 685 - 703, XP001022116, ISSN: 0001-527X *
PO S ET AL: "Heteromultimeric assembly of human potassium channels: Molecular basis of a transient outward current?", CIRCULATION RESEARCH, vol. 72, no. 6, 1993, pages 1326 - 1336, XP001029529, ISSN: 0009-7330 *
PONGS OLAF ET AL: "Functional and molecular aspects of voltage-gated K+ channel beta subunits.", ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, vol. 868, 30 April 1999 (1999-04-30), Conference on Molecular and Functional Diversity of Ion Channels and Receptors;New York, New York, USA; May 14-17, 1998, diversity of ion channels and receptors. April 30, 1999 New York Academy of Sci, pages 344 - 355, XP001119013, ISBN: 1-57331-177-4 *
POST MARC A ET AL: "Kv2.1 and electrically silent Kv6.1 potassium channel subunits combine and express a novel current.", FEBS LETTERS, vol. 399, no. 1-2, 1996, pages 177 - 182, XP001022178, ISSN: 0014-5793 *
SCHEFFER INGRID E ET AL: "Genetics of the epilepsies.", CURRENT OPINION IN PEDIATRICS, vol. 12, no. 6, December 2000 (2000-12-01), pages 536 - 542, XP001033798, ISSN: 1040-8703 *

Also Published As

Publication number Publication date
AU2002314132A1 (en) 2002-12-09
WO2002096944A2 (fr) 2002-12-05

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