WO2002096217A1 - Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives - Google Patents
Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives Download PDFInfo
- Publication number
- WO2002096217A1 WO2002096217A1 PCT/KR2002/000908 KR0200908W WO02096217A1 WO 2002096217 A1 WO2002096217 A1 WO 2002096217A1 KR 0200908 W KR0200908 W KR 0200908W WO 02096217 A1 WO02096217 A1 WO 02096217A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alpha
- succinate
- tocopheryl
- methylpolyethyleneglycolyl
- animals
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
Definitions
- Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives
- the present invention relates to a feed additive composition
- a feed additive composition comprising polyethoxylated alpha tocopherol ester derivatives represented by the following formula 1
- R is CH 3 OCH 2 CH 2 (OCH 2 CH 2 ) n , where n is an integer of 2-400, and to a process for preparing the same.
- Vitamin E (DL-alpha-tocopherol) represented by the following formula 2 is widely used as an antioxidant in a living body, its clinically applied fields are extended, and its need tends to be increased.
- Vitamin E is a compound having a hydroxyl group on a benzene ring, and has a characteristic of liposolubility that is not dissolved in water. Generally, since Vitamin E itself is easily oxidized, it is chemically unstable. Moreover, tocopherol quinone, an oxidation product, does not have a biological activity of Vitamin E. Therefore, to prevent oxidation of vitamin E, the more stabilized derivatives of vitamin E can be prepared synthetically. Such derivatives include tocopherol acetate, tocopherol palmitate, tocopherol succinate, etc. These derivatives have advantages in storage and transportation, since they have relatively higher stability than Vitamin itself. Also, they are effective substitutes of Vitamin E, since they have a permissible stability for pharmacological purpose.
- Vitamin E ester compounds when the above-mentioned Vitamin E ester compounds are absorbed via in vivo intestinal tracts, they contact with pancreatic enzyme or intestinal enzyme, and are completely hydrolyzed to be absorbed in the form of tocopherol in vivo.
- Vitamin E substitutes are widely used in all feed for the whole livestock.
- tocopherol acetate is widely used as a source providing Vitamin E in feed for pigs and has an effect as an agent improving the pork's flesh.
- the above active compounds are used as a feed additive for providing Vitamin E, they must be prepared in a liquid phase by dissolving them in water or an organic solvent and diluting the solution, or be prepared in a solid phase by absorbing, them on a solid excipient that may be used as a feed additive.
- a physical property of the above active compounds is viscous liquid, the compounds can not be used as such in the process for preparing feed that they must be added by a small portion. Even if the compounds are used, there are many problems.
- the present inventors have found that the polyethoxylated alpha tocopherol ester derivatives used in the present invention have a high solubility-in-water, are hard to be oxidized, have a chemical stability, and are useful as a source providing Vitamin E. Based on these findings, they have developed a feed additive composition for animals. Therefore, they have completed the present invention.
- the object of the present invention is to provide a feed additive composition for animals comprising a derivative of the above formula 1.
- Another object of the present invention is to provide a process for preparing the above feed additive composition for animals by dissolving or absorbing a derivative of the above formula 1 in an excipient to obtain a solid phase formulation or a liquid phase formulation.
- the feed additive composition for animals of the present invention contains polyethoxylated alpha tocopherol ester derivatives of the following formula 1 as an effective ingredient:
- R is CH 3 OCH 2 CH 2 (OCH 2 CH 2 ) n , where n is an integer of 2-400.
- the feed additive composition for animals in accordance with the present invention may be formulated in the form of a solid or liquid phase by dissolving or absorbing the derivative of the above formula 1 in an excipient.
- the excipient used for formulation includes an absorbent, an inorganic or organic medium or a vegetable oil.
- the absorbent includes zeosil, sugar, cellulose, powdered milk, meat meal and powdered bones, rough and fine cereal powder, corncob, starch or defatted bran.
- the inorganic or organic medium includes water or ethanol used as a solvent, sodium chloride, calcium carbonate, bicarbonate, aluminum oxide, silica, alumina, precipitated or colloid silicon dioxide or phosphate.
- the vegetable oil includes soybean oil, castor oil, cotton-seed oil, palm oil, etc.
- the formulations in accordance with the present invention are suitable for a feed additive for animals, more preferably, a feed additive for livestock and a feed additive for fish, providing Vitamin E.
- the process for preparing the formulation of alpha-tocopherol ester derivatives of formula 1 comprises dissolving a soluble (carrying) medium in alpha-tocopherol ester derivatives of formula 1 in case of being a liquid phase; or adding alpha-tocopherol ester derivative of formula 1 and an excipient to a suitable solvent, if necessary, heating the mixture and evaporating the solvent.
- the alpha-tocopherol ester derivative and the excipient are mixed in a ratio of 3:2 to 1:99, so that the concentration of the formulation of alpha-tocopherol ester derivative is 60% to 1% (w/w).
- the suitable solvent used for preparing the formulation (solid) is an inert organic solvent, for example, alcohol (methanol or ethanol), ether, hydrocarbon (toluene, benzene and xylene) as well as water.
- alcohol methanol or ethanol
- ether ether
- hydrocarbon toluene, benzene and xylene
- the concentration of the active compound in the feed is usually 1.0 to 500 ppm (on the basis of Vitamin E), and, preferably, 10 to 200 ppm, based upon the total weight of the feed.
- the active materials may be used as a source providing Vitamin E for the human body and animals, and, most suitably, for animals and fish.
- the livestock to which may be applied are the following animals: mammals such as cattle, horse, pig, sheep, goat, cat, dog, and camel; animals with fur such as mink and chinchilla; animals that live in a zoological garden; laboratory animals such as mouse and rat; birds such as goose, fowl, turkey, duck, and pigeon; laboratory birds such as parrot and macaw; fish such as carp, trout, salmon, tench and eel; ornament fish; aquatic fish; and reptiles such as crocodile and snake.
- 300g of the title formulation is obtained by using 240g of defatted bran instead of 240g of corncorb in Example 4.
- body weight, feed intake, daily gain, feed conversion rate (feed intake/body weight gain; the lower the value, the better the ef ⁇ icency), and carcass grade of the effective test group were measured and compared.
- a total of 160 pigs were used in the above experiment (5 pigs/pen). Average body weights of the animals were as follows: 78 ⁇ 2 kg (50 pigs) by 1 replication, 74 ⁇ 2 kg (50 pigs) by 2 replication, 70 ⁇ 2 Kg (50 pigs) by 3 replication. Equal numbers of male and female were used without any difference between treatments. The above experiment was carried out by using three way cross hybrid pigs.
- the body weights of the pigs were measured, and the acclimation procedure against fighting one another was introduced for one week, with providing them with the feed. Then, the body weight of the livestock was measured again, and the test feed was provided to them.
- the compound of the present invention may be used as a source providing vitamin E in feed for animals.
- the present compound has a more excellent effect on improving the meat quality than DL- ⁇ - tocopherol acetate which has been widely used.
- the present compound may maximize increments of the body weight and feed conversion ratio which could not be expected by using tocopherol acetate. Therefore, the present compound may be used as a source providing vitamin E in feed for all species.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Physiology (AREA)
- Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
Abstract
The present invention relates to a feed additive composition for animals which comprises polyethoxylated alpha tocopherol ester derivatives of formula 1 as an effective ingredient. When the feed additive composition for animals in accordance with the present invention is provided to livestock, the present composition has an excellent effect on improving the meat quality and increment of the body weight and feed conversion ratio. Therefore, the present composition may be used as a source providing Vitamin E in feed for the all species.
Description
Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives
TECHNICAL FIELD
The present invention relates to a feed additive composition comprising polyethoxylated alpha tocopherol ester derivatives represented by the following formula 1
R is CH3OCH2CH2(OCH2CH2)n, where n is an integer of 2-400, and to a process for preparing the same.
BACKGROUND ART
Vitamin E (DL-alpha-tocopherol) represented by the following formula 2 is widely used as an antioxidant in a living body, its clinically applied fields are extended, and its need tends to be increased.
Vitamin E is a compound having a hydroxyl group on a benzene ring, and has a characteristic of liposolubility that is not dissolved in water. Generally, since Vitamin E itself is easily oxidized, it is chemically unstable. Moreover, tocopherol quinone, an oxidation product, does not have a biological activity of Vitamin E. Therefore, to prevent
oxidation of vitamin E, the more stabilized derivatives of vitamin E can be prepared synthetically. Such derivatives include tocopherol acetate, tocopherol palmitate, tocopherol succinate, etc. These derivatives have advantages in storage and transportation, since they have relatively higher stability than Vitamin itself. Also, they are effective substitutes of Vitamin E, since they have a permissible stability for pharmacological purpose.
Furthermore, in case of oral administration, when the above-mentioned Vitamin E ester compounds are absorbed via in vivo intestinal tracts, they contact with pancreatic enzyme or intestinal enzyme, and are completely hydrolyzed to be absorbed in the form of tocopherol in vivo.
Therefore, Vitamin E substitutes are widely used in all feed for the whole livestock. Particularly, it is known that tocopherol acetate is widely used as a source providing Vitamin E in feed for pigs and has an effect as an agent improving the pork's flesh.
In order that the above active compounds are used as a feed additive for providing Vitamin E, they must be prepared in a liquid phase by dissolving them in water or an organic solvent and diluting the solution, or be prepared in a solid phase by absorbing, them on a solid excipient that may be used as a feed additive. However, since a physical property of the above active compounds is viscous liquid, the compounds can not be used as such in the process for preparing feed that they must be added by a small portion. Even if the compounds are used, there are many problems.
DISCLOSURE OF THE INVENTION
The present inventors have found that the polyethoxylated alpha tocopherol ester derivatives used in the present invention have a high solubility-in-water, are hard to be oxidized, have a chemical stability, and are useful as a source providing Vitamin E. Based on these findings, they have developed a feed additive composition for animals.
Therefore, they have completed the present invention.
The object of the present invention is to provide a feed additive composition for animals comprising a derivative of the above formula 1.
Another object of the present invention is to provide a process for preparing the above feed additive composition for animals by dissolving or absorbing a derivative of the above formula 1 in an excipient to obtain a solid phase formulation or a liquid phase formulation.
The feed additive composition for animals of the present invention contains polyethoxylated alpha tocopherol ester derivatives of the following formula 1 as an effective ingredient:
R is CH3OCH2CH2(OCH2CH2)n, where n is an integer of 2-400.
Among the above compounds of formula 1, the compounds that have the definition of R, wherein n is an integer of 2-50, are preferable.
The feed additive composition for animals in accordance with the present invention may be formulated in the form of a solid or liquid phase by dissolving or absorbing the derivative of the above formula 1 in an excipient.
The excipient used for formulation includes an absorbent, an inorganic or organic medium or a vegetable oil. The absorbent includes zeosil, sugar, cellulose, powdered milk, meat meal and powdered bones, rough and fine cereal powder, corncob, starch or defatted bran.
In addition, the inorganic or organic medium includes water or ethanol used as a solvent, sodium chloride, calcium carbonate, bicarbonate, aluminum oxide, silica, alumina, precipitated or colloid silicon dioxide or phosphate. The vegetable oil includes soybean oil, castor oil, cotton-seed oil, palm oil, etc.
Specific formulations of polyethoxylated alpha tocopherol ester derivatives are mentioned as follows: as a liquid formulation, DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl- succinate (n=6)-ethanol/water; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl- succinate (n=ll)-ethanol/water; and DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl- succinate (n=44)-ethanol/water; and as a solid formulation, DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=6)-corncorb; DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=l l)-corncorb; DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=44)-corncorb; DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=6)-defatted bran; DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=ll)-defatted bran; and DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=44)-defatted bran.
The formulations in accordance with the present invention are suitable for a feed additive for animals, more preferably, a feed additive for livestock and a feed additive for fish, providing Vitamin E.
Preferably, the process for preparing the formulation of alpha-tocopherol ester derivatives of formula 1 comprises dissolving a soluble (carrying) medium in alpha-tocopherol ester derivatives of formula 1 in case of being a liquid phase; or adding alpha-tocopherol ester derivative of formula 1 and an excipient to a suitable solvent, if necessary, heating the mixture and evaporating the solvent. At this time, the alpha-tocopherol ester derivative and the excipient are mixed in a ratio of 3:2 to 1:99, so that the concentration of the formulation of alpha-tocopherol ester derivative is 60% to 1% (w/w).
The suitable solvent used for preparing the formulation (solid) is an inert organic solvent,
for example, alcohol (methanol or ethanol), ether, hydrocarbon (toluene, benzene and xylene) as well as water.
When the above formulation is added to a feed for animals, the concentration of the active compound in the feed is usually 1.0 to 500 ppm (on the basis of Vitamin E), and, preferably, 10 to 200 ppm, based upon the total weight of the feed.
As mentioned above, the active materials may be used as a source providing Vitamin E for the human body and animals, and, most suitably, for animals and fish. The livestock to which may be applied are the following animals: mammals such as cattle, horse, pig, sheep, goat, cat, dog, and camel; animals with fur such as mink and chinchilla; animals that live in a zoological garden; laboratory animals such as mouse and rat; birds such as goose, fowl, turkey, duck, and pigeon; laboratory birds such as parrot and macaw; fish such as carp, trout, salmon, tench and eel; ornament fish; aquatic fish; and reptiles such as crocodile and snake.
BEST MODE FOR CARRYING OUT THE INVENTION
The present invention is explained in detail by means of the following examples, but it is not limited to them.
Example 1. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6)-ethanol/water liquid
60g of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6, average molecular weight: 863) is dissolved in 40g of 95% ethanol to obtain lOOg of the title formulation [60%(w/w)].
Example 2. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=ll)-ethanol/water liquid
molecular weight: 1063) is dissolved in 40g of 95% ethanol to obtain lOOg of the title formulation [60%(w/w)j\
Example 3. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=44)-ethanol/water liquid
60g of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=44, average molecular weight: 2153) is dissolved in 40g of 95% ethanol to obtain lOOg of the title formulation [60%(w/w)].
Example 4. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6)-corncorb formulation
60g of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6, average molecular weight: 863) is dissolved in 100ml of methylene dichloride. 240g of coracorb is introduced into the resulting solution, and stirred for 30 minutes to 1 hour at room temperature. 300g of the title formulation in solid phase [20% (w/w)] is obtained by vaporization of methylene dichloride under reduced pressure.
Example 5. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=ll)-corncorb formulation
300g of the title formulation is obtained by using 60g of DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=ll, average molecular weight: 1063) instead of the tocopherol derivative (n=6) in Example 4.
Example 6. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=44)-corncorb formulation
300g of the title formulation is obtained by using 60g of DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=44, average molecular weight: 2153) instead of the tocopherol derivative (n=6) in Example 4.
Example 7. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6)-defatted bran formulation
300g of the title formulation is obtained by using 240g of defatted bran instead of 240g of corncorb in Example 4.
Example 8. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=ll)-defatted bran formulation
300g of the title formulation is obtained by using 60g of DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=ll, average molecular weight: 1063) and 240g of defatted bran instead of DL-alpha-tocopheryl-ω-methylenepolyethyleneglycolyl-succinate (n=6, average molecular weight: 863) and corncorb in Example 4.
Example 9. Preparation of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=44)-defatted bran formulation
300g of the title formulation is obtained by using 60g of DL-alpha-tocopheryl-ω- methylpolyethyleneglycolyl-succinate (n=44, average molecular weight: 2153) and 240g of defatted bran instead of DL-alpha-tocopheryl-ω-methylenepolyethyleneglycolyl- succinate (n=6, average molecular weight: 863) and corncorb in Example 4.
Experimental Example 1: Measuring an effect on the pig's growth performance and meat quality
Compared with tocopherol acetate as the standard control compound, the compound (n=ll) of formula 1 was prepared in an ethanol/water liquid as Example 2, and the formulation was provided with pig, together with the feed. In order to measure an effect on the pig's growth and meat quality, body weight, feed intake, daily gain, feed conversion rate (feed intake/body weight gain; the lower the value, the better the efϊicency), and carcass grade of the effective test group were measured and compared.
A total of 160 pigs were used in the above experiment (5 pigs/pen). Average body weights of the animals were as follows: 78 ± 2 kg (50 pigs) by 1 replication, 74 ± 2 kg (50 pigs) by 2 replication, 70 ± 2 Kg (50 pigs) by 3 replication. Equal numbers of male and female were used without any difference between treatments. The above experiment was carried out by using three way cross hybrid pigs.
1. Experiment Method
The body weights of the pigs were measured, and the acclimation procedure against fighting one another was introduced for one week, with providing them with the feed. Then, the body weight of the livestock was measured again, and the test feed was provided to them.
Basic feed adjusted to energy protein of a test feed for pigs and the mixture of vitamins and minerals were separately purchased as the test feed, and a conventional vitamin preparation was purchased as Vitamin E. The compound of formula 1 was separately provided. The animals were freely intaking the feed and water. The experiment was carried out for 6 weeks, the body weights and feed conversion rate were measured every three weeks. After completing the experiment, the animals were slaughtered and graded.
2. Experiment Result
[Table 1]
Result of measuring effectiveness in pigs
[Table 2]
Results of estimating carcass grade (n=15 pigs, average value)
INDUSTRIAL AVAILABILITY
As shown in the above Experimental Example, the compound of the present invention may be used as a source providing vitamin E in feed for animals. Especially, in case of the feed for pigs, the present compound has a more excellent effect on improving the meat quality than DL-α- tocopherol acetate which has been widely used. In addition, the present compound may maximize increments of the body weight and feed conversion ratio which could not be expected by using tocopherol acetate. Therefore, the present compound may be used as a source providing vitamin E in feed for all species.
Claims
1. A feed additive composition for animals which comprises polyethoxylated alpha tocopherol ester derivative of the following formula 1 as an effective ingredient:
5.
1 wherein,
R is CH3OCH2CH2(OCH2CH2)n, where n is an integer of 2-400.
10
2. The composition of Claim 1, wherein the compound of formula 1 is selected from the group consisting of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=6), DL-alpha-tocopheryl- o-methylpolyethyleneglycolyl-succinate (n=ll) and DL- alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=44).
15.
3. The composition of Claim 1, in which the compound of formula 1 is contained in the form of a solid phase or liquid phase formulation.
4. The composition of Claim 3, wherein the liquid phase formulation is selected from 0 the group consisting of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate
(n=6)-ethanol/water; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=l l)-ethanol/water; and DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl- succinate (n=44)-ethanol/water; and the solid phase formulation is selected from the group consisting of DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate 5 (n=6)-corncorb; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate
(n= 11 )-coracorb; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate
(n=44)-corncorb; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate
(n=6)-defatted bran; DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl-succinate (n=ll)-defatted bran; and DL-alpha-tocopheryl-ω-methylpolyethyleneglycolyl- succinate (n=44)-defatted bran.
5. The composition of Claim 3, wherein the solid phase or liquid phase formulation is contained in an amount of 1.0 to 60 % by weight.
6. A process for preparing the feed additive composition for animals of Claim 1, characterized in that polyethoxylated alpha tocopherol ester derivative of the following formula 1 is dissolved or absorbed in an excipient to obtain a solid or liquid phase formulation:
1 wherein, R is CH3OCH2CH2(OCH2CH2)n, where n is an integer of 2-400.
7. The process of Claim 6, wherein the excipient is selected from the group consisting of absorbent, inorganic or organic medium, and vegetable oil.
8 The process of Claim 7, wherein the excipient is selected from the group consisting of zeosil, sugar, cellulose, powdered milk, meat meal and powdered bones, rough and fine cereal powder, corncob, starch, defatted bran, water, ethanol, sodium chloride, calcium carbonate, bicarbonate, aluminum oxide, silica, alumina, precipitated or colloid silicon dioxide, phosphate, soybean oil, castor oil, cottonseed oil, and palm oil.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR20010029224 | 2001-05-26 | ||
| KR2001/29224 | 2001-05-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002096217A1 true WO2002096217A1 (en) | 2002-12-05 |
Family
ID=19710000
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2002/000908 WO2002096217A1 (en) | 2001-05-26 | 2002-05-15 | Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives |
Country Status (2)
| Country | Link |
|---|---|
| KR (1) | KR100428702B1 (en) |
| WO (1) | WO2002096217A1 (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7639332B2 (en) | 2003-12-18 | 2009-12-29 | Sharp Kabushiki Kaisha | Display element and display device, driving method of display element, and program |
| CN104222691A (en) * | 2014-10-10 | 2014-12-24 | 珠海海龙生物科技有限公司 | Snakehead larva fish feed and application thereof |
| CN104522417A (en) * | 2014-12-30 | 2015-04-22 | 青岛农业大学 | Micro-granular feed for larva fish of bostrichthys sinensis and preparation method of micro-granular feed |
| CN104996799A (en) * | 2015-07-17 | 2015-10-28 | 句容市天贵农副产品有限公司 | Feed composition for improving tenderness of old goose meat |
| CN105076754A (en) * | 2015-07-17 | 2015-11-25 | 句容市天贵农副产品有限公司 | Marinated old goose meat quality improving feed composition |
| WO2018102888A1 (en) * | 2016-12-09 | 2018-06-14 | Phosphagenics Limited | A method for improving performance parameters of an animal |
| US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| US10188670B2 (en) | 2011-03-15 | 2019-01-29 | Phosphagenics Limited | Composition |
| US10973761B2 (en) | 2015-12-09 | 2021-04-13 | Phosphagenics Limited | Pharmaceutical formulation |
| US11753435B2 (en) | 2016-12-21 | 2023-09-12 | Avecho Biotechnology Limited | Process |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0570793A (en) * | 1991-09-10 | 1993-03-23 | Nissei Baadeishie Kk | Granular lipid composition |
| US5235073A (en) * | 1991-03-29 | 1993-08-10 | Pacific Chemical Co., Ltd. | Polyethoxylated vitamin e |
| JPH06279439A (en) * | 1993-03-25 | 1994-10-04 | Kanto Denka Kogyo Co Ltd | New compound and its production |
| US5869704A (en) * | 1998-08-24 | 1999-02-09 | Eastman Chemical Company | Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3392668B2 (en) * | 1996-11-20 | 2003-03-31 | 中部飼料株式会社 | Eggs enriched with sesame lignan substance and vitamin E, method for producing enriched eggs, and health foods based on enriched eggs |
| JPH10155429A (en) * | 1996-11-27 | 1998-06-16 | Showa Denko Kk | Method for supplying vitamin e to animals and tocopherol phosphate for animals or its salts composition |
-
2002
- 2002-05-08 KR KR10-2002-0025267A patent/KR100428702B1/en not_active IP Right Cessation
- 2002-05-15 WO PCT/KR2002/000908 patent/WO2002096217A1/en not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5235073A (en) * | 1991-03-29 | 1993-08-10 | Pacific Chemical Co., Ltd. | Polyethoxylated vitamin e |
| JPH0570793A (en) * | 1991-09-10 | 1993-03-23 | Nissei Baadeishie Kk | Granular lipid composition |
| JPH06279439A (en) * | 1993-03-25 | 1994-10-04 | Kanto Denka Kogyo Co Ltd | New compound and its production |
| US5869704A (en) * | 1998-08-24 | 1999-02-09 | Eastman Chemical Company | Water-dispersible or water-soluble D-tocotrienol compounds and methods for making therefor |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7639332B2 (en) | 2003-12-18 | 2009-12-29 | Sharp Kabushiki Kaisha | Display element and display device, driving method of display element, and program |
| US10071030B2 (en) | 2010-02-05 | 2018-09-11 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
| US10188670B2 (en) | 2011-03-15 | 2019-01-29 | Phosphagenics Limited | Composition |
| CN104222691A (en) * | 2014-10-10 | 2014-12-24 | 珠海海龙生物科技有限公司 | Snakehead larva fish feed and application thereof |
| CN104522417A (en) * | 2014-12-30 | 2015-04-22 | 青岛农业大学 | Micro-granular feed for larva fish of bostrichthys sinensis and preparation method of micro-granular feed |
| CN104996799A (en) * | 2015-07-17 | 2015-10-28 | 句容市天贵农副产品有限公司 | Feed composition for improving tenderness of old goose meat |
| CN105076754A (en) * | 2015-07-17 | 2015-11-25 | 句容市天贵农副产品有限公司 | Marinated old goose meat quality improving feed composition |
| US10973761B2 (en) | 2015-12-09 | 2021-04-13 | Phosphagenics Limited | Pharmaceutical formulation |
| WO2018102888A1 (en) * | 2016-12-09 | 2018-06-14 | Phosphagenics Limited | A method for improving performance parameters of an animal |
| US11753435B2 (en) | 2016-12-21 | 2023-09-12 | Avecho Biotechnology Limited | Process |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100428702B1 (en) | 2004-04-28 |
| KR20020090293A (en) | 2002-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Mirocha et al. | Fungus metabolites toxic to animals | |
| US5380745A (en) | Medicinal composition | |
| Lin et al. | Dietary copper requirement reevaluation for juvenile grouper, Epinephelus malabaricus, with an organic copper source | |
| Sandnes | Vitamin C in fish nutrition-a review | |
| WO2002096217A1 (en) | Feed additive composition for animals comprising polyethoxylated alpha tocopherol ester derivatives | |
| Huang et al. | Dietary vitamin C requirement of genetically improved farmed Tilapia, Oreochromis Niloticus | |
| Bunnell et al. | Studies on Encephalomalacia in the Chick: 3. The Influence of Feeding or Injecting Various Tocopherols and other Antioxidants on the Incidence of Encephalomalacia | |
| EP0170538B1 (en) | Use of certain compounds in livestock food as growth promotants | |
| GB2037306A (en) | Cyclodextrin-camomile inclusion complexes and pharmaceutical compositions containing them | |
| KR101388061B1 (en) | Anti-foot-and-mouth disease virus agent for animal belonging to family suidae or sheep, and method for prevention or treatment of foot-and-mouth disease in animal belonging to family suidae or sheep | |
| US4711897A (en) | Animal feed methods and compositions using cysteamine | |
| Zhang et al. | Effect of RRR-α-tocopherol succinate on the growth and immunity in broilers | |
| JPH10175866A (en) | Stress reaction relaxing agent for animal and stress reaction relaxation | |
| US4761421A (en) | Use of certain compounds in livestock food as growth promotants for better feed utilization and improved carcass composition | |
| Liu et al. | Effect of amount and duration of waste green tea powder on the growth performance, carcass characteristics, blood parameters, and lipid metabolites of growing broilers | |
| JPS5874607A (en) | Anticoccidial composition | |
| KR910002420B1 (en) | Animal growth promotant | |
| RU2285399C1 (en) | Method for increasing meat productivity of youngsters in fattening swine | |
| KR100847354B1 (en) | A method for breeding animal using by the leaf of Pinus Koraiensis and the functional animal meat products using thereby | |
| KR100450274B1 (en) | Feed additive compositions for animals comprising polyethoxylated ascorbic acid derivatives | |
| HU229229B1 (en) | Crystal modification of a cyclic depsipeptide having improved strength | |
| JPS5984849A (en) | Growth accelerative phenylethylamine derivatives | |
| Mahan et al. | Efficacy of dietary sodium selenite and calcium selenite provided in the diet at approved, marginally toxic, and toxic levels to growing swine | |
| Pradhan et al. | Effect of dietary boron supplementation on serum biochemical and carcass characteristics in broiler chicken | |
| US4847302A (en) | Use of certain compounds in livestock food as growth promotants for better feed utilization and improved carcass composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW |
|
| AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
| DFPE | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101) | ||
| REG | Reference to national code |
Ref country code: DE Ref legal event code: 8642 |
|
| 122 | Ep: pct application non-entry in european phase | ||
| NENP | Non-entry into the national phase |
Ref country code: JP |
|
| WWW | Wipo information: withdrawn in national office |
Country of ref document: JP |