WO2002094984A2 - Process for preparing purified shilajit composition from native shilajit - Google Patents
Process for preparing purified shilajit composition from native shilajit Download PDFInfo
- Publication number
- WO2002094984A2 WO2002094984A2 PCT/US2002/014259 US0214259W WO02094984A2 WO 2002094984 A2 WO2002094984 A2 WO 2002094984A2 US 0214259 W US0214259 W US 0214259W WO 02094984 A2 WO02094984 A2 WO 02094984A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- shilajit
- acid
- dbps
- composition according
- Prior art date
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- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 1
- XJFGDLJQUJQUEI-UHFFFAOYSA-N dodecyl decanoate dodecyl octanoate Chemical compound CCCCCCCCCCCCOC(=O)CCCCCCC.CCCCCCCCCCCCOC(=O)CCCCCCCCC XJFGDLJQUJQUEI-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000000804 electron spin resonance spectroscopy Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000011790 ferrous sulphate Substances 0.000 description 1
- 235000003891 ferrous sulphate Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 229940075529 glyceryl stearate Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 229960004881 homosalate Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- BAUYGSIQEAFULO-UHFFFAOYSA-L iron(2+) sulfate (anhydrous) Chemical compound [Fe+2].[O-]S([O-])(=O)=O BAUYGSIQEAFULO-UHFFFAOYSA-L 0.000 description 1
- 229910000359 iron(II) sulfate Inorganic materials 0.000 description 1
- 229940113094 isopropylparaben Drugs 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 150000001455 metallic ions Chemical class 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 229960001047 methyl salicylate Drugs 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 210000003470 mitochondria Anatomy 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 239000012038 nucleophile Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 229960001679 octinoxate Drugs 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 1
- 229960001173 oxybenzone Drugs 0.000 description 1
- KLAKIAVEMQMVBT-UHFFFAOYSA-N p-hydroxy-phenacyl alcohol Natural products OCC(=O)C1=CC=C(O)C=C1 KLAKIAVEMQMVBT-UHFFFAOYSA-N 0.000 description 1
- 229940100460 peg-100 stearate Drugs 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000008263 repair mechanism Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000013049 sediment Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
- 229960005055 sodium ascorbate Drugs 0.000 description 1
- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940098760 steareth-2 Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the purified shilajit of the invention includes (a) mono- or di- hydroxy or tetrameric dibenzo- ⁇ -pyrones (DBP) having the formulas shown below:
- Alcohol soluble ext. value (% w/w) 26.8
Abstract
Description
Claims
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT02739223T ATE308890T1 (en) | 2001-05-18 | 2002-05-03 | METHOD FOR PRODUCING A PURIFIED SHILAJIT COMPOSITION FROM NATIVE SHILAJIT |
AU2002311886A AU2002311886A1 (en) | 2001-05-18 | 2002-05-03 | Process for preparing purified shilajit composition from native shilajit |
DE60207234T DE60207234T2 (en) | 2001-05-18 | 2002-05-03 | PROCESS FOR PREPARING A CLEANED SHILAJITE COMPOSITION FROM NATIVE SHILAJIT |
EP02739223A EP1387614B1 (en) | 2001-05-18 | 2002-05-03 | Process for preparing purified shilajit composition from native shilajit |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/860,890 | 2001-05-18 | ||
US09/860,890 US6440436B1 (en) | 2001-05-18 | 2001-05-18 | Process for preparing purified shilajit composition from native shilajit |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2002094984A2 true WO2002094984A2 (en) | 2002-11-28 |
WO2002094984A3 WO2002094984A3 (en) | 2003-03-06 |
Family
ID=25334290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/014259 WO2002094984A2 (en) | 2001-05-18 | 2002-05-03 | Process for preparing purified shilajit composition from native shilajit |
Country Status (7)
Country | Link |
---|---|
US (2) | US6440436B1 (en) |
EP (1) | EP1387614B1 (en) |
AT (1) | ATE308890T1 (en) |
AU (1) | AU2002311886A1 (en) |
DE (1) | DE60207234T2 (en) |
ES (1) | ES2252467T3 (en) |
WO (1) | WO2002094984A2 (en) |
Cited By (8)
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EP1435982A1 (en) * | 2001-09-21 | 2004-07-14 | Natreon Inc. | Delivery system for pharmaceutical, nutritional and cosmetic ingredients |
WO2011041920A2 (en) * | 2009-10-09 | 2011-04-14 | Centro Internacional De Biomedicina | Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin b12 and vitamin b6 and the use thereof for preventing and/or treating neurodegenerative diseases and/or the cognitive deterioration associated with cerebral ageing |
EP2364700A1 (en) * | 2006-04-27 | 2011-09-14 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis |
US8475776B2 (en) | 2005-04-28 | 2013-07-02 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis |
US9381187B2 (en) | 2011-02-16 | 2016-07-05 | Paloma Pharmaceuticals, Inc. | Radiation countermeasure agents |
USRE46558E1 (en) | 2005-04-28 | 2017-09-26 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis |
US11020373B2 (en) | 2012-06-27 | 2021-06-01 | Amazentis Sa | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
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US6440436B1 (en) * | 2001-05-18 | 2002-08-27 | Natreon Inc. | Process for preparing purified shilajit composition from native shilajit |
US20050085454A1 (en) * | 2003-10-16 | 2005-04-21 | Natreon Inc. | Phenolic antioxidant-chromium complexes for treatment or prevention of type 2 diabetes or glucose intolerance |
US20050233942A1 (en) * | 2004-04-14 | 2005-10-20 | Shibnath Ghosal | Oxygenated dibenzo-alpha-pyrone chromoproteins |
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US20070212434A1 (en) * | 2006-03-07 | 2007-09-13 | Day Kenneth S | Compositions and methods for human use containing fulvic acid |
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US20120213756A1 (en) * | 2011-02-21 | 2012-08-23 | Rosemary Petralia | Nutraceutical beverage |
US10314874B2 (en) | 2014-04-08 | 2019-06-11 | Christopher Vandecar | Plant and animal extracts and related methods |
US10183047B2 (en) | 2014-05-21 | 2019-01-22 | Natreon, Inc. | Chromium-containing compositions in combination with Phyllanthus emblica and shilajit having synergistic effects for improving endothelial function and cardiovascular health |
WO2016054433A1 (en) | 2014-10-02 | 2016-04-07 | Natreon, Inc. | Promoting muscle building and repair and treating disorders related to collagen and pertinent proteins by using shilajit |
JP2017007951A (en) * | 2015-06-17 | 2017-01-12 | 公立大学法人岡山県立大学 | Photoaging inhibitor comprising urolithin |
JP2017014154A (en) * | 2015-07-01 | 2017-01-19 | 公立大学法人岡山県立大学 | Hyaluronic acid production promoter containing urolithins |
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JP2017031108A (en) * | 2015-08-04 | 2017-02-09 | 公立大学法人岡山県立大学 | Anti-wrinkle agent, collagen production promoter, mmp-1 production inhibitor, and elastase activity inhibitor that contain urolithin |
US11292731B2 (en) | 2017-02-02 | 2022-04-05 | Christopher Vandecar | Method and apparatus for treating contaminated fluid medium |
US20180256471A1 (en) * | 2017-03-08 | 2018-09-13 | Amazentis Sa | Skin Treatment Methods |
KR101844849B1 (en) | 2017-07-27 | 2018-04-04 | 주식회사 제니버 | composite composition containing hemp-seed oil and kenaf-seed oil and method for producing |
WO2020005215A1 (en) * | 2018-06-26 | 2020-01-02 | Natreon, Inc. | Improvement of blood microperfusion to skin by shilajit |
CN109363956B (en) * | 2018-12-29 | 2022-05-13 | 广州市科能化妆品科研有限公司 | Application of ganoderma lucidum extract, whitening water lotion and preparation method thereof |
WO2022040321A1 (en) * | 2020-08-19 | 2022-02-24 | Natreon, Inc. | Protection against coronavirus infection by extracts and extract components |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5405613A (en) * | 1991-12-11 | 1995-04-11 | Creative Nutrition Canada Corp. | Vitamin/mineral composition |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6440436B1 (en) * | 2001-05-18 | 2002-08-27 | Natreon Inc. | Process for preparing purified shilajit composition from native shilajit |
-
2001
- 2001-05-18 US US09/860,890 patent/US6440436B1/en not_active Expired - Lifetime
-
2002
- 2002-05-03 EP EP02739223A patent/EP1387614B1/en not_active Expired - Lifetime
- 2002-05-03 DE DE60207234T patent/DE60207234T2/en not_active Expired - Lifetime
- 2002-05-03 AU AU2002311886A patent/AU2002311886A1/en not_active Abandoned
- 2002-05-03 AT AT02739223T patent/ATE308890T1/en not_active IP Right Cessation
- 2002-05-03 ES ES02739223T patent/ES2252467T3/en not_active Expired - Lifetime
- 2002-05-03 WO PCT/US2002/014259 patent/WO2002094984A2/en not_active Application Discontinuation
- 2002-08-01 US US10/210,528 patent/US6869612B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5405613A (en) * | 1991-12-11 | 1995-04-11 | Creative Nutrition Canada Corp. | Vitamin/mineral composition |
Non-Patent Citations (1)
Title |
---|
See also references of EP1387614A2 * |
Cited By (15)
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EP1435982A4 (en) * | 2001-09-21 | 2010-10-20 | Natreon Inc | Delivery system for pharmaceutical, nutritional and cosmetic ingredients |
EP1435982A1 (en) * | 2001-09-21 | 2004-07-14 | Natreon Inc. | Delivery system for pharmaceutical, nutritional and cosmetic ingredients |
US8475776B2 (en) | 2005-04-28 | 2013-07-02 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis |
USRE46558E1 (en) | 2005-04-28 | 2017-09-26 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat diseases characterized by cellular proliferation and angiogenesis |
EP2364700A1 (en) * | 2006-04-27 | 2011-09-14 | Paloma Pharmaceuticals, Inc. | Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis |
WO2011041920A3 (en) * | 2009-10-09 | 2011-06-03 | Centro Internacional De Biomedicina | Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin b12 and vitamin b6 and the use thereof for preventing and/or treating neurodegenerative diseases and/or the cognitive deterioration associated with cerebral ageing |
GB2487871A (en) * | 2009-10-09 | 2012-08-08 | Ct Internac De Biomedicina | Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin b12 and vitamin b6 and the use thereof for preventing and/or treating neurod |
AU2010305251B2 (en) * | 2009-10-09 | 2013-12-19 | Neuroinnovation Spa | Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin B12 and Vitamin B6 and the use thereof for preventing and/or treating neurodegenerative diseases and/or the cognitive deterioration associated with cerebral ageing |
GB2487871B (en) * | 2009-10-09 | 2017-04-05 | Neuroinnovation Spa | Nutraceutical composition comprising extract of Andean shilajit, folic acid, vitamin B12 and vitamin B6 |
WO2011041920A2 (en) * | 2009-10-09 | 2011-04-14 | Centro Internacional De Biomedicina | Nutraceutical composition that comprises extract of shilajit, folic acid, vitamin b12 and vitamin b6 and the use thereof for preventing and/or treating neurodegenerative diseases and/or the cognitive deterioration associated with cerebral ageing |
US9381187B2 (en) | 2011-02-16 | 2016-07-05 | Paloma Pharmaceuticals, Inc. | Radiation countermeasure agents |
US11020373B2 (en) | 2012-06-27 | 2021-06-01 | Amazentis Sa | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
US11931335B2 (en) | 2012-06-27 | 2024-03-19 | Amazentis Sa | Enhancing autophagy or increasing longevity by administration of urolithins or precursors thereof |
US11931336B2 (en) | 2012-06-27 | 2024-03-19 | Amazentis Sa | Enhancing autophagy or increasing longevity by administration of urolithins |
US11969408B2 (en) | 2017-03-08 | 2024-04-30 | Amazentis Sa | Method for improving mitophagy in subjects |
Also Published As
Publication number | Publication date |
---|---|
EP1387614A4 (en) | 2004-09-15 |
EP1387614A2 (en) | 2004-02-11 |
DE60207234D1 (en) | 2005-12-15 |
US6869612B2 (en) | 2005-03-22 |
DE60207234T2 (en) | 2006-08-03 |
US20030039662A1 (en) | 2003-02-27 |
WO2002094984A3 (en) | 2003-03-06 |
US6440436B1 (en) | 2002-08-27 |
EP1387614B1 (en) | 2005-11-09 |
ES2252467T3 (en) | 2006-05-16 |
ATE308890T1 (en) | 2005-11-15 |
AU2002311886A1 (en) | 2002-12-03 |
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