WO2002094316A3 - Method of preparing aluminium-hydroxide gel - Google Patents

Method of preparing aluminium-hydroxide gel Download PDF

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Publication number
WO2002094316A3
WO2002094316A3 PCT/IB2002/002870 IB0202870W WO02094316A3 WO 2002094316 A3 WO2002094316 A3 WO 2002094316A3 IB 0202870 W IB0202870 W IB 0202870W WO 02094316 A3 WO02094316 A3 WO 02094316A3
Authority
WO
WIPO (PCT)
Prior art keywords
gel
preparing
hydroxide gel
aluminium
antigen
Prior art date
Application number
PCT/IB2002/002870
Other languages
French (fr)
Other versions
WO2002094316A2 (en
Inventor
Simon Johannes Barteling
Original Assignee
Simon Johannes Barteling
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Simon Johannes Barteling filed Critical Simon Johannes Barteling
Priority to AU2002319571A priority Critical patent/AU2002319571A1/en
Publication of WO2002094316A2 publication Critical patent/WO2002094316A2/en
Publication of WO2002094316A3 publication Critical patent/WO2002094316A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention provides a method of preparing a vaccine including the steps of providing an antigen; preparing an aluminium-hydroxide gel (AH-gel); and mixing the antigen with the AH-gel to form an AH-gel-antigen complex. This invention further provides a method of preparing aluminium-hydroxide gel (AH-gel) including the steps of providing Al2O3 in particulate form; dissolving the Al2O3 particles in an alkali; and neutralising the alkali with an acid. Further included in the invention are vaccines and AH-gel prepared according to the methods of the invention.
PCT/IB2002/002870 2001-05-23 2002-05-21 Method of preparing aluminium-hydroxide gel WO2002094316A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002319571A AU2002319571A1 (en) 2001-05-23 2002-05-21 Method of preparing aluminium-hydroxide gel

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200103286 2001-05-23
ZA2001/3286 2001-05-23

Publications (2)

Publication Number Publication Date
WO2002094316A2 WO2002094316A2 (en) 2002-11-28
WO2002094316A3 true WO2002094316A3 (en) 2003-05-15

Family

ID=25589141

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/002870 WO2002094316A2 (en) 2001-05-23 2002-05-21 Method of preparing aluminium-hydroxide gel

Country Status (2)

Country Link
AU (1) AU2002319571A1 (en)
WO (1) WO2002094316A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524192B2 (en) * 2008-08-19 2013-09-03 Kyowa Chemical Industry Co., Ltd. Aluminum hydroxide gel particle and production method thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395221A (en) * 1965-04-15 1968-07-30 Warner Lambert Pharmaceutical Gel froming aluminum hydroxide
FR2255080A1 (en) * 1973-12-20 1975-07-18 Almasfuezitoei Timfoeldgyar Dry aluminium hydroxide gels prodn - by carbon dioxide neutralisation of technical aluminate liquors
US4780307A (en) * 1984-10-23 1988-10-25 Rafa Laboratories Ltd. Aluminum hydroxide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3395221A (en) * 1965-04-15 1968-07-30 Warner Lambert Pharmaceutical Gel froming aluminum hydroxide
FR2255080A1 (en) * 1973-12-20 1975-07-18 Almasfuezitoei Timfoeldgyar Dry aluminium hydroxide gels prodn - by carbon dioxide neutralisation of technical aluminate liquors
US4780307A (en) * 1984-10-23 1988-10-25 Rafa Laboratories Ltd. Aluminum hydroxide

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BARTELING S J: "CONDITIONS FOR PROPER FORMALDEHYDE INACTIVATION OF FOOT AND MOUSE DISEASE ALHYDROGEL VACCINES", DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, KARGER, BASEL, CH, vol. 60, 1985, pages 323 - 329, XP008010079, ISSN: 0301-5149 *
HART L.D.: "Alumina chemicals (Science and Technology Handbook)", 1990, AMERICAN CERAMIC SOCIETY, US, OHIO, WESTERVILLE, XP002229412, 174990 *
THAM K M ET AL: "ANTIBODY AND CELL-MEDIATED IMMUNE RESPONSES TO FELINE HERPESVIRUS 1 FOLLOWING INACTIVATED VACCINE AND CHALLENGE", JOURNAL OF VETERINARY MEDICINE SERIES B, vol. 34, no. 8, 1987, pages 585 - 597, XP008012521, ISSN: 0931-1793 *

Also Published As

Publication number Publication date
WO2002094316A2 (en) 2002-11-28
AU2002319571A1 (en) 2002-12-03

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