WO2002092767A3 - Detection d'arnm de synthase gd2 et utilisations correspondantes - Google Patents

Detection d'arnm de synthase gd2 et utilisations correspondantes Download PDF

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Publication number
WO2002092767A3
WO2002092767A3 PCT/US2002/015037 US0215037W WO02092767A3 WO 2002092767 A3 WO2002092767 A3 WO 2002092767A3 US 0215037 W US0215037 W US 0215037W WO 02092767 A3 WO02092767 A3 WO 02092767A3
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WO
WIPO (PCT)
Prior art keywords
synthase
provides
mrna
detection
synthase mrna
Prior art date
Application number
PCT/US2002/015037
Other languages
English (en)
Other versions
WO2002092767A2 (fr
Inventor
Irene Y Cheung
Nai-Kong V Cheung
Original Assignee
Sloan Kettering Inst Cancer
Irene Y Cheung
Nai-Kong V Cheung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sloan Kettering Inst Cancer, Irene Y Cheung, Nai-Kong V Cheung filed Critical Sloan Kettering Inst Cancer
Priority to US10/477,435 priority Critical patent/US20040115688A1/en
Priority to AU2002256523A priority patent/AU2002256523A1/en
Priority to CA 2447435 priority patent/CA2447435A1/fr
Publication of WO2002092767A2 publication Critical patent/WO2002092767A2/fr
Publication of WO2002092767A3 publication Critical patent/WO2002092767A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/113—Real time assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Cette invention se rapporte à un procédé servant à mesurer l'ARNm de synthase GD2 et consistant à cet effet: (a) à obtenir un échantillon d'ARNm; (b) à effectuer une réaction RT-PCR quantitative en temps réel sur cet échantillon, en utilisant des amorces appropriées de synthase GD2; et (c) à déterminer la quantité d'ARNm de synthase GD2. Cette invention concerne également un procédé pour diagnostiquer un sujet atteint de cancer exprimant la synthase GD2, ainsi qu'un procédé pour déterminer les stades d'un cancer exprimant la synthase GD2 chez un sujet et, finalement, un kit de détection de synthase GD2.
PCT/US2002/015037 2001-05-11 2002-04-19 Detection d'arnm de synthase gd2 et utilisations correspondantes WO2002092767A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US10/477,435 US20040115688A1 (en) 2002-04-19 2002-04-19 Detection of gd2 synthase mrna and uses thereof
AU2002256523A AU2002256523A1 (en) 2001-05-11 2002-04-19 Detection of gd2 synthase mrna and uses thereof
CA 2447435 CA2447435A1 (fr) 2001-05-11 2002-04-19 Detection d'arnm de synthase gd2 et utilisations correspondantes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29052701P 2001-05-11 2001-05-11
US60/290,527 2001-05-11

Publications (2)

Publication Number Publication Date
WO2002092767A2 WO2002092767A2 (fr) 2002-11-21
WO2002092767A3 true WO2002092767A3 (fr) 2003-12-18

Family

ID=23116406

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/015037 WO2002092767A2 (fr) 2001-05-11 2002-04-19 Detection d'arnm de synthase gd2 et utilisations correspondantes

Country Status (3)

Country Link
AU (1) AU2002256523A1 (fr)
CA (1) CA2447435A1 (fr)
WO (1) WO2002092767A2 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006089091A2 (fr) * 2005-02-18 2006-08-24 Memorial Sloan-Kettering Cancer Center Procedes pour la detection de maladie residuelle minimale
EP2573567A4 (fr) * 2010-05-17 2014-01-08 Tokyo Inst Tech Procédé de détection du cancer de l'estomac
CN105039515B (zh) * 2015-06-05 2018-04-20 中国农业科学院兰州畜牧与兽药研究所 牦牛肌纤维类型组成的荧光定量pcr检测引物及检测方法
US20220133872A1 (en) * 2019-02-08 2022-05-05 University Of Florida Research Foundation, Inc. A monophosphoryl lipid-a liposome based cancer vaccine

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YUYAMA Y. ET AL.: "Enhanced expression of GM2/GD2 synthase mRNA in human gastrointestinal cancer", CANCER, vol. 75, 1995, pages 1273 - 1280, XP002965007 *

Also Published As

Publication number Publication date
AU2002256523A1 (en) 2002-11-25
CA2447435A1 (fr) 2002-11-21
WO2002092767A2 (fr) 2002-11-21

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