WO2002092634A3 - Für histaminrezeptorsubklassen spezifische antikörper - Google Patents

Für histaminrezeptorsubklassen spezifische antikörper Download PDF

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Publication number
WO2002092634A3
WO2002092634A3 PCT/EP2002/004678 EP0204678W WO02092634A3 WO 2002092634 A3 WO2002092634 A3 WO 2002092634A3 EP 0204678 W EP0204678 W EP 0204678W WO 02092634 A3 WO02092634 A3 WO 02092634A3
Authority
WO
WIPO (PCT)
Prior art keywords
histamine receptor
specific antibodies
antibodies
receptor subclasses
subclasses
Prior art date
Application number
PCT/EP2002/004678
Other languages
English (en)
French (fr)
Other versions
WO2002092634A2 (de
Inventor
Ute Schaefer
Andras Falus
Original Assignee
Ute Schaefer
Andras Falus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2001120816 external-priority patent/DE10120816A1/de
Application filed by Ute Schaefer, Andras Falus filed Critical Ute Schaefer
Publication of WO2002092634A2 publication Critical patent/WO2002092634A2/de
Publication of WO2002092634A3 publication Critical patent/WO2002092634A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft Antikörper, die spezifisch jeweils gegen die Histaminrezeptorsubklassen H1, H2, H3 gerichtet sind. Die Antikörper wirken agonistisch und inhibieren die Histaminbindung. Aufgrund dieser Effekte sind die Antikörper beispielsweise zur Prävention oder therapeutischen Behandlung von Inflamationserkrankungen und zum Nachweis von spezifischen Histaminrezeptorproteinen geeignet.
PCT/EP2002/004678 2001-04-27 2002-04-27 Für histaminrezeptorsubklassen spezifische antikörper WO2002092634A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2001120816 DE10120816A1 (de) 2001-04-27 2001-04-27 Für Histaminrezeptorsubklassen spezifische Antikörper
DE10120816.2 2001-04-27
DE10213916 2002-03-28
DE10213916.4 2002-03-28

Publications (2)

Publication Number Publication Date
WO2002092634A2 WO2002092634A2 (de) 2002-11-21
WO2002092634A3 true WO2002092634A3 (de) 2003-10-30

Family

ID=26009186

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004678 WO2002092634A2 (de) 2001-04-27 2002-04-27 Für histaminrezeptorsubklassen spezifische antikörper

Country Status (1)

Country Link
WO (1) WO2002092634A2 (de)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2283239A (en) * 1993-10-29 1995-05-03 Ucb Sa Human H1 histamine receptor
WO1998020040A1 (en) * 1996-11-07 1998-05-14 Incyte Pharmaceuticals, Inc. Novel histamine h2 receptor
WO2000020011A1 (en) * 1998-10-07 2000-04-13 Ortho-Mcneil Pharmaceutical, Inc. Isolated dna encoding human h3 histamine receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2283239A (en) * 1993-10-29 1995-05-03 Ucb Sa Human H1 histamine receptor
WO1998020040A1 (en) * 1996-11-07 1998-05-14 Incyte Pharmaceuticals, Inc. Novel histamine h2 receptor
WO2000020011A1 (en) * 1998-10-07 2000-04-13 Ortho-Mcneil Pharmaceutical, Inc. Isolated dna encoding human h3 histamine receptor
WO2002061087A2 (en) * 2000-12-19 2002-08-08 Lifespan Biosciences, Inc. Antigenic peptides, such as for g protein-coupled receptors (gpcrs), antibodies thereto, and systems for identifying such antigenic peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NEDERKOORN P H J ET AL: "THE AGONISTIC BINDING SITE AT THE HISTAMINE H2 RECEPTOR. II. THEORETICAL INVESTIGATIONS OF HISTAMINE BINDING TO RECEPTOR MODELS OF THE SEVEN ALPHA-HELICAL TRANSMEMBRANE DOMAIN", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, ESCOM SCIENCE PUBLISHERS BV, XX, vol. 10, no. 5, October 1996 (1996-10-01), pages 479 - 489, XP008014252, ISSN: 0920-654X *
SIPPL W ET AL: "DEVELOPMENT OF A BINDING SITE MODEL FOR HISTAMINE H3-RECEPTOR AGONISTS", PHARMAZIE, VEB VERLAG VOLK UND GESUNDHEIT. BERLIN, DD, vol. 53, no. 7, 1997, pages 433 - 437, XP000882768, ISSN: 0031-7144 *
TER LAAK A M ET AL: "Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation.", JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN. NETHERLANDS AUG 1995, vol. 9, no. 4, August 1995 (1995-08-01), pages 319 - 330, XP008013905, ISSN: 0920-654X *

Also Published As

Publication number Publication date
WO2002092634A2 (de) 2002-11-21

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