WO2002088383A3 - Method and system for identifying targets by nucleocytoplasmic cycling and use thereof - Google Patents

Method and system for identifying targets by nucleocytoplasmic cycling and use thereof Download PDF

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Publication number
WO2002088383A3
WO2002088383A3 PCT/EP2002/004602 EP0204602W WO02088383A3 WO 2002088383 A3 WO2002088383 A3 WO 2002088383A3 EP 0204602 W EP0204602 W EP 0204602W WO 02088383 A3 WO02088383 A3 WO 02088383A3
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WO
WIPO (PCT)
Prior art keywords
steps
cell signaling
identifying targets
individual
nucleocytoplasmic
Prior art date
Application number
PCT/EP2002/004602
Other languages
French (fr)
Other versions
WO2002088383A2 (en
Inventor
Ursula Klingmueller
Ira Swameye
Jens Timmer
Thorsten G Mueller
Original Assignee
Max Planck Gesellschaft
Ursula Klingmueller
Ira Swameye
Jens Timmer
Thorsten G Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Ursula Klingmueller, Ira Swameye, Jens Timmer, Thorsten G Mueller filed Critical Max Planck Gesellschaft
Priority to EP02750862A priority Critical patent/EP1392850A2/en
Priority to AU2002338551A priority patent/AU2002338551A1/en
Publication of WO2002088383A2 publication Critical patent/WO2002088383A2/en
Publication of WO2002088383A3 publication Critical patent/WO2002088383A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention relates to a method, system and use thereof, in particular for identifying targets for efficient medical intervention and/or for predicting the effect of therapeutic agents and/or for dynamically modeling complex cell signaling networks and/or for remote sensing of cellular signaling. The method comprises the following steps: analyzing at least one cell signaling pathway, separating the cell signaling pathway into individual functional steps, transferring the individual steps into respective coupled differential equations comprising quantitative dynamical parameters by specifying the general differential equation (F) to describe the dynamics of individual steps of signal transduction such as covalent modifications, complex formation, cleavage, degradation, release and exchange.
PCT/EP2002/004602 2001-04-27 2002-04-25 Method and system for identifying targets by nucleocytoplasmic cycling and use thereof WO2002088383A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02750862A EP1392850A2 (en) 2001-04-27 2002-04-25 Method and system for identifying targets by nucleocytoplasmic cycling and use thereof
AU2002338551A AU2002338551A1 (en) 2001-04-27 2002-04-25 Method and system for identifying targets by nucleocytoplasmic cycling and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01110071 2001-04-27
EP01110071.6 2001-04-27

Publications (2)

Publication Number Publication Date
WO2002088383A2 WO2002088383A2 (en) 2002-11-07
WO2002088383A3 true WO2002088383A3 (en) 2003-10-09

Family

ID=8177235

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004602 WO2002088383A2 (en) 2001-04-27 2002-04-25 Method and system for identifying targets by nucleocytoplasmic cycling and use thereof

Country Status (3)

Country Link
EP (1) EP1392850A2 (en)
AU (1) AU2002338551A1 (en)
WO (1) WO2002088383A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015148236A1 (en) * 2014-03-27 2015-10-01 The Procter & Gamble Company Methods for evaluating effects of a treatment on biological processes and pathways
WO2023231203A1 (en) * 2022-05-31 2023-12-07 医渡云（北京）技术有限公司 Drug efficacy prediction method and apparatus based on digital cell model, medium, and device
CN116343912B (en) * 2023-05-26 2023-07-28 山东科技大学 Method and system for predicting phosphorylation activity of phosphorylation system in biological signal path

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61109717A (en) * 1984-11-02 1986-05-28 Teruhiko Beppu Antitumor agent
US5914891A (en) * 1995-01-20 1999-06-22 Board Of Trustees, The Leland Stanford Junior University System and method for simulating operation of biochemical systems
US5930154A (en) * 1995-01-17 1999-07-27 Intertech Ventures, Ltd. Computer-based system and methods for information storage, modeling and simulation of complex systems organized in discrete compartments in time and space
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
WO2001018735A2 (en) * 1999-09-10 2001-03-15 Becton Dickinson And Company Apparatus and methods for drug analysis and development

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61109717A (en) * 1984-11-02 1986-05-28 Teruhiko Beppu Antitumor agent
US5930154A (en) * 1995-01-17 1999-07-27 Intertech Ventures, Ltd. Computer-based system and methods for information storage, modeling and simulation of complex systems organized in discrete compartments in time and space
US5914891A (en) * 1995-01-20 1999-06-22 Board Of Trustees, The Leland Stanford Junior University System and method for simulating operation of biochemical systems
US6132969A (en) * 1998-06-19 2000-10-17 Rosetta Inpharmatics, Inc. Methods for testing biological network models
WO2001018735A2 (en) * 1999-09-10 2001-03-15 Becton Dickinson And Company Apparatus and methods for drug analysis and development

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 96, no. 11 Part 2, 16 November 2000 (2000-11-16), 42nd Annual Meeting of the American Society of Hematology;San Francisco, California, USA; December 01-05, 2000, pages 141b, ISSN: 0006-4971 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 16 November 2000 (2000-11-16), SWAMEYE IRA ET AL: "Properties of a signalling pathway revealed by dynamical modelling.", XP002247344, Database accession no. PREV200100291771 *
PATENT ABSTRACTS OF JAPAN vol. 010, no. 292 (C - 376) 3 October 1986 (1986-10-03) *

Also Published As

Publication number Publication date
EP1392850A2 (en) 2004-03-03
WO2002088383A2 (en) 2002-11-07
AU2002338551A1 (en) 2002-11-11

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