WO2002088169A3 - Preparation of glucocorticosteroids, 16, 17 acetals or ketals of pregnane derivatives - Google Patents

Preparation of glucocorticosteroids, 16, 17 acetals or ketals of pregnane derivatives Download PDF

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Publication number
WO2002088169A3
WO2002088169A3 PCT/SE2002/000814 SE0200814W WO02088169A3 WO 2002088169 A3 WO2002088169 A3 WO 2002088169A3 SE 0200814 W SE0200814 W SE 0200814W WO 02088169 A3 WO02088169 A3 WO 02088169A3
Authority
WO
WIPO (PCT)
Prior art keywords
glucocorticosteroids
preparation
ketals
acetals
pregnane derivatives
Prior art date
Application number
PCT/SE2002/000814
Other languages
French (fr)
Other versions
WO2002088169A2 (en
Inventor
Joergen Blixt
Bengt Aaslund
Original Assignee
Astrazeneca Ab
Joergen Blixt
Bengt Aaslund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab, Joergen Blixt, Bengt Aaslund filed Critical Astrazeneca Ab
Priority to AU2002307602A priority Critical patent/AU2002307602A1/en
Publication of WO2002088169A2 publication Critical patent/WO2002088169A2/en
Publication of WO2002088169A3 publication Critical patent/WO2002088169A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/0026—Oxygen-containing hetero ring cyclic ketals
    • C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Processes for the preparation of compounds of formula (I) involving transacetalisation of the relevant acetonide, or esterification of a compound of formula (I) wherein X is OH. Compounds of formula (I) may be anti-inflammatory, immunosupressive and anti-allergic glucocorticosteroids useful as therapeutic agents.
PCT/SE2002/000814 2001-04-27 2002-04-24 Preparation of glucocorticosteroids, 16, 17 acetals or ketals of pregnane derivatives WO2002088169A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002307602A AU2002307602A1 (en) 2001-04-27 2002-04-24 Preparation of glucocorticosteroids, 16, 17 acetals or ketals of pregnane derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0110411A GB0110411D0 (en) 2001-04-27 2001-04-27 Chemical process
GB0110411.6 2001-04-27

Publications (2)

Publication Number Publication Date
WO2002088169A2 WO2002088169A2 (en) 2002-11-07
WO2002088169A3 true WO2002088169A3 (en) 2003-01-09

Family

ID=9913626

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2002/000814 WO2002088169A2 (en) 2001-04-27 2002-04-24 Preparation of glucocorticosteroids, 16, 17 acetals or ketals of pregnane derivatives

Country Status (3)

Country Link
AU (1) AU2002307602A1 (en)
GB (1) GB0110411D0 (en)
WO (1) WO2002088169A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100087147A (en) 2007-10-04 2010-08-03 아스트라제네카 아베 Steroidal [3,2-c]pyrazole compounds, with glucocorticoid activity
WO2009108118A1 (en) * 2008-02-27 2009-09-03 Astrazeneca Ab 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use
WO2009112557A2 (en) * 2008-03-13 2009-09-17 Farmabios S.P.A. Process for the preparation of pregnane derivatives
UY32520A (en) 2009-04-03 2010-10-29 Astrazeneca Ab COMPOUNDS THAT HAVE AGONIST ACTIVITY OF THE GLUCOCORTICOESTEROID RECEPTOR

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1405519A (en) * 1973-07-18 1975-09-10 American Cyanamid Co Triamcinolone derivative
EP0355859A1 (en) * 1985-04-04 1990-02-28 Aktiebolaget Draco Process for the preparation of intermediates for 11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-3,20-dione 16-alpha,17-alpha-acetals and 21-esters thereof
WO1992013872A1 (en) * 1991-02-04 1992-08-20 Aktiebolaget Astra Novel steroids
JPH07277987A (en) * 1994-04-05 1995-10-24 Green Cross Corp:The Steroid antiphlogistic external agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1405519A (en) * 1973-07-18 1975-09-10 American Cyanamid Co Triamcinolone derivative
EP0355859A1 (en) * 1985-04-04 1990-02-28 Aktiebolaget Draco Process for the preparation of intermediates for 11-beta,16-alpha,17-alpha,21-tetrahydroxypregna-3,20-dione 16-alpha,17-alpha-acetals and 21-esters thereof
WO1992013872A1 (en) * 1991-02-04 1992-08-20 Aktiebolaget Astra Novel steroids
JPH07277987A (en) * 1994-04-05 1995-10-24 Green Cross Corp:The Steroid antiphlogistic external agent

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] AKABOSHI FUMIHIKO ET AL.: "Topical pharmaceutical compositions contating anntiinflammatory steroids", XP002954685, accession no. STN Database accession no. 1996:38628 *

Also Published As

Publication number Publication date
WO2002088169A2 (en) 2002-11-07
AU2002307602A1 (en) 2002-11-11
GB0110411D0 (en) 2001-06-20

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