WO2002086132A3 - Viral vector system to transduce or infect a target adipose tissue site - Google Patents

Viral vector system to transduce or infect a target adipose tissue site Download PDF

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Publication number
WO2002086132A3
WO2002086132A3 PCT/GB2002/001830 GB0201830W WO02086132A3 WO 2002086132 A3 WO2002086132 A3 WO 2002086132A3 GB 0201830 W GB0201830 W GB 0201830W WO 02086132 A3 WO02086132 A3 WO 02086132A3
Authority
WO
WIPO (PCT)
Prior art keywords
adipose tissue
transduce
infect
viral vector
vector system
Prior art date
Application number
PCT/GB2002/001830
Other languages
French (fr)
Other versions
WO2002086132A2 (en
Inventor
Susan A Kingsman
Kyriacos Mitrophanous
Fiona Margaret Ellard
Original Assignee
Oxford Biomedica Ltd
Susan A Kingsman
Kyriacos Mitrophanous
Fiona Margaret Ellard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oxford Biomedica Ltd, Susan A Kingsman, Kyriacos Mitrophanous, Fiona Margaret Ellard filed Critical Oxford Biomedica Ltd
Priority to AU2002251310A priority Critical patent/AU2002251310A1/en
Priority to EP02720242A priority patent/EP1385969A2/en
Publication of WO2002086132A2 publication Critical patent/WO2002086132A2/en
Publication of WO2002086132A3 publication Critical patent/WO2002086132A3/en
Priority to US10/690,320 priority patent/US20050106732A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/15045—Special targeting system for viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2810/00—Vectors comprising a targeting moiety
    • C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
    • C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides the use of a viral vector system to transduce/infect a target adipose tissue site. the invention also provides a method of treating and/or preventing a disease in a subject and use of a viral vector system in the manufacture of a pharmaceutical composition to transduce/infect a target adipose tissue site wherein the disease is associated with a derangement in the metabolism of adipose tissue.
PCT/GB2002/001830 2001-04-20 2002-04-19 Viral vector system to transduce or infect a target adipose tissue site WO2002086132A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002251310A AU2002251310A1 (en) 2001-04-20 2002-04-19 Viral vector system to transduce or infect a target adipose tissue site
EP02720242A EP1385969A2 (en) 2001-04-20 2002-04-19 Viral vector system to transduce or infect a target adipose tissue site
US10/690,320 US20050106732A1 (en) 2001-04-20 2003-10-20 Vector system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0109781A GB0109781D0 (en) 2001-04-20 2001-04-20 Vector system
GB0109781.5 2001-04-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/690,320 Continuation-In-Part US20050106732A1 (en) 2001-04-20 2003-10-20 Vector system

Publications (2)

Publication Number Publication Date
WO2002086132A2 WO2002086132A2 (en) 2002-10-31
WO2002086132A3 true WO2002086132A3 (en) 2003-05-08

Family

ID=9913181

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001830 WO2002086132A2 (en) 2001-04-20 2002-04-19 Viral vector system to transduce or infect a target adipose tissue site

Country Status (4)

Country Link
EP (1) EP1385969A2 (en)
AU (1) AU2002251310A1 (en)
GB (1) GB0109781D0 (en)
WO (1) WO2002086132A2 (en)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049827A2 (en) * 1996-06-26 1997-12-31 Cornell Research Foundation, Inc. Adenoviral mediated gene transfer in adipocytes and related implants
WO1998013071A1 (en) * 1996-09-24 1998-04-02 Merck & Co., Inc. Gene therapy for inhibition of angiogenesis
GB2327224A (en) * 1997-07-09 1999-01-20 Mayo Foundation Gene transfer to adipocytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997049827A2 (en) * 1996-06-26 1997-12-31 Cornell Research Foundation, Inc. Adenoviral mediated gene transfer in adipocytes and related implants
WO1998013071A1 (en) * 1996-09-24 1998-04-02 Merck & Co., Inc. Gene therapy for inhibition of angiogenesis
GB2327224A (en) * 1997-07-09 1999-01-20 Mayo Foundation Gene transfer to adipocytes

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
KAFRI T: "Lentivirus vectors: difficulties and hopes before clinical trials.", CURRENT OPINION IN MOLECULAR THERAPEUTICS. ENGLAND AUG 2001, vol. 3, no. 4, August 2001 (2001-08-01), pages 316 - 326, XP001097685, ISSN: 1464-8431 *
KIM V N ET AL: "MINIMAL REQUIREMENT FOR A LENTIVIRUS VECTOR BASED ON HUMAN IMMUNODEFICIENCY VIRUS TYPE 1", JOURNAL OF VIROLOGY, THE AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 72, no. 1, January 1998 (1998-01-01), pages 811 - 816, XP000872453, ISSN: 0022-538X *
TRONO D: "LENTIVIRAL VECTORS: TURNING A DEADLY FOE INTO A THERAPEUTIC AGENT", GENE THERAPY, MACMILLAN PRESS LTD., BASINGSTOKE, GB, vol. 7, 2000, pages 20 - 23, XP000916379, ISSN: 0969-7128 *

Also Published As

Publication number Publication date
EP1385969A2 (en) 2004-02-04
AU2002251310A1 (en) 2002-11-05
WO2002086132A2 (en) 2002-10-31
GB0109781D0 (en) 2001-06-13

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