WO2002086051A3 - Analyse d'acide nucleique - Google Patents

Analyse d'acide nucleique Download PDF

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Publication number
WO2002086051A3
WO2002086051A3 PCT/IB2002/002298 IB0202298W WO02086051A3 WO 2002086051 A3 WO2002086051 A3 WO 2002086051A3 IB 0202298 W IB0202298 W IB 0202298W WO 02086051 A3 WO02086051 A3 WO 02086051A3
Authority
WO
WIPO (PCT)
Prior art keywords
mass
oligomers
monomers
differentiable
nucleic acid
Prior art date
Application number
PCT/IB2002/002298
Other languages
English (en)
Other versions
WO2002086051A2 (fr
Inventor
Frank Grosveld
Original Assignee
Univ Erasmus
Frank Grosveld
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Erasmus, Frank Grosveld filed Critical Univ Erasmus
Priority to JP2002583567A priority Critical patent/JP2005500824A/ja
Priority to EP02735871A priority patent/EP1385932A2/fr
Priority to CA002445248A priority patent/CA2445248A1/fr
Priority to BR0209205-0A priority patent/BR0209205A/pt
Publication of WO2002086051A2 publication Critical patent/WO2002086051A2/fr
Priority to US10/693,308 priority patent/US20040137570A1/en
Publication of WO2002086051A3 publication Critical patent/WO2002086051A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

La présente invention concerne un procédé destiné à la réalisation d'une banque d'oligomères différentiables par leur masse, consistant à utiliser un bassin hétérogène de monomères, les monomères étant modifiés par addition d'un ou de plusieurs marqueurs de masse ; à utiliser éventuellement un bassin hétérogène de monomères non marqués ; à déterminer les séquences de monomères des oligomères à représenter dans la banque et à calculer le nombre et la nature des marqueurs de mass à introduire dans chaque monomère pour que chaque oligomère diffère en masse ; et à assembler une pluralité de monomères marqués et, éventuellement, un ou plusieurs monomères non marqués, pour former les oligomères.
PCT/IB2002/002298 2001-04-24 2002-04-24 Analyse d'acide nucleique WO2002086051A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2002583567A JP2005500824A (ja) 2001-04-24 2002-04-24 核酸分析
EP02735871A EP1385932A2 (fr) 2001-04-24 2002-04-24 Analyse d'acide nucleique
CA002445248A CA2445248A1 (fr) 2001-04-24 2002-04-24 Analyse d'acide nucleique par la differention de la masse d'oligomeres
BR0209205-0A BR0209205A (pt) 2001-04-24 2002-04-24 Análise de ácido nucléico
US10/693,308 US20040137570A1 (en) 2001-04-24 2003-10-24 Immunoglobulin 2

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0110030.4 2001-04-24
GBGB0110030.4A GB0110030D0 (en) 2001-04-24 2001-04-24 RNA genomics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/693,308 Continuation US20040137570A1 (en) 2001-04-24 2003-10-24 Immunoglobulin 2

Publications (2)

Publication Number Publication Date
WO2002086051A2 WO2002086051A2 (fr) 2002-10-31
WO2002086051A3 true WO2002086051A3 (fr) 2003-11-20

Family

ID=9913360

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/002298 WO2002086051A2 (fr) 2001-04-24 2002-04-24 Analyse d'acide nucleique

Country Status (6)

Country Link
EP (1) EP1385932A2 (fr)
JP (1) JP2005500824A (fr)
BR (1) BR0209205A (fr)
CA (1) CA2445248A1 (fr)
GB (1) GB0110030D0 (fr)
WO (1) WO2002086051A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0423873D0 (en) * 2004-10-27 2004-12-01 Univ Erasmus Nucleic acid analysis
CN102169118B (zh) * 2011-04-15 2012-01-25 华瑞同康生物技术（深圳）有限公司 血清或尿液中8-氧代脱氧鸟苷的定量检测方法
US20140221223A1 (en) * 2012-12-10 2014-08-07 Advandx, Inc. Use of Probes for Mass Spectrometric Identification and Resistance Determination of Microorganisms or Cells

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002728A1 (fr) * 1997-07-11 1999-01-21 Brax Group Limited Caracterisation des acides nucleiques
WO1999045150A1 (fr) * 1998-03-02 1999-09-10 Isis Pharmaceuticals, Inc. Procedes de spectrometrie de masse pour criblage biomoleculaire
WO1999057318A2 (fr) * 1998-05-07 1999-11-11 Sequenom, Inc. Analyse de molecules par spectrometrie de masse a desorption/ionisation par laser, assistee par matrice absorbant l'infrarouge
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
US6194144B1 (en) * 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194144B1 (en) * 1993-01-07 2001-02-27 Sequenom, Inc. DNA sequencing by mass spectrometry
US6027890A (en) * 1996-01-23 2000-02-22 Rapigene, Inc. Methods and compositions for enhancing sensitivity in the analysis of biological-based assays
WO1999002728A1 (fr) * 1997-07-11 1999-01-21 Brax Group Limited Caracterisation des acides nucleiques
WO1999045150A1 (fr) * 1998-03-02 1999-09-10 Isis Pharmaceuticals, Inc. Procedes de spectrometrie de masse pour criblage biomoleculaire
WO1999057318A2 (fr) * 1998-05-07 1999-11-11 Sequenom, Inc. Analyse de molecules par spectrometrie de masse a desorption/ionisation par laser, assistee par matrice absorbant l'infrarouge

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ISOLA ET AL.: "MALDI-TOF mass spectrometric methods for detection of hybridized DNA oligomers", ANAL. CHEM., vol. 73, 1 May 2001 (2001-05-01), pages 2126 - 2131, XP002239467 *

Also Published As

Publication number Publication date
BR0209205A (pt) 2005-12-13
WO2002086051A2 (fr) 2002-10-31
GB0110030D0 (en) 2001-06-13
JP2005500824A (ja) 2005-01-13
CA2445248A1 (fr) 2002-10-31
EP1385932A2 (fr) 2004-02-04

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