WO2002085353A1

WO2002085353A1 - 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor xa inhibitors

Info

Publication number: WO2002085353A1
Application number: PCT/US2002/012204
Authority: WO
Inventors: Donald J. Pinto; Robert A. Galemmo
Original assignee: Bristol-Myers Squibb Company
Priority date: 2001-04-18
Filing date: 2002-04-17
Publication date: 2002-10-31
Also published as: CA2441772A1; US20030022916A1; US6706730B2; EP1379244A1; EP1379244A4; WO2002085353A9

Abstract

The present application describes 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones of Formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring R is 3-amido or 4-methoxy, R1 is trifluoromethyl or amido, and R2 is aminomethyl, N-methylaminomethyl, and N,N-dimethylaminomethyl. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.

Description

THREE DIMENSIONAL PIPE COIL

This invention regards a pipe coil of the type used for interconnection of fixed installations such as wells on the seabed.

When interconnecting large fixed installations, it is of considerable importance that the pipe connections be constructed in a manner so as to allow both intentional and unintentional displacement and rotation at the connection points to be absorbed by the pipe connections without the connections of the installations or parts of the pipe connections being overstrained.

Relative displacement and torsion may occur as a result of e.g. changes in temperature, installation displacement or wrong assembly. According to prior art, it is necessary to connect the individual fixed installations by means of relatively long pipe connections preferably deviated in the horizontal plane, where the pipe connections are designed for generally resilient absorption of displacement and rotations of the type described above. The use of pipe coils according to prior art entails several limitations with regard to the mutual positioning of the installations and their orientation in relation to each other. As an example, it is not practical for two installations that are to be connected, to be oriented in a way such that their connection couplings have the same direction, as the deviated connecting pipes, which in the horizontal plane may be in the form of a Z, must be connected to the installations by means of couplings oriented along different axes. Installations often have to be arranged with a greater spacing than that which is desirable, in order to leave the necessary space for pipe coils.

All known pipe coils designed to connect installations on the seabed are designed principally to lie directly on the seabed. Depending on the nature of the seabed, relatively high friction may arise between the seabed and the pipe coil, whereby the pipe coil must be extended further in order to function satisfactorily.

The invention aims to remedy the disadvantages of prior art.

This aim is achieved in accordance with the invention by the characteristics stated in the description below and in the appended claims.

A pipe coil comprising more than two essentially parallel- lengths of piping is arranged such that two of the piping lengths are typically located in a lowermost plane. The remaining lengths of the pipe coil are arranged in one or more overlying planes. In a preferred embodiment, the pipe coil comprises three parallel lengths of piping of which two are located at seabed level or immediately above seabed level, while the third length of piping is provided at a higher level and between the two lower lengths of piping. Each of the two lowermost piping lengths are via one end portion connected to a connecting pipe running to a normally higher connecting point on the installation, and at the opposite end portion connected to the higher piping length via one or more bends .

The connecting pipes, which in this preferred embodiment are therefore located at the respective end portions of the pipe coils, will then usually project outward at right angles from the longitudinal axis of the pipe coil. Thus the pipe coil is particularly suited for absorbing axial displacement in the connecting pipes, but it is also well suited to resilient absorption of displacement and. rotations that may occur in the other directions . Thus the pipe coil reduces the occurring forces and moments so as to allow the capacity requirements for the coupling tools and couplings to be reduced significantly.

During normal coupling conditions it will be expedient to place the pipe coil according to the invention in an enclosing cage. During production and transport such a cage will constitute packaging to which the pipe coil may be braced. The connecting pipes may by means of rigging equipment that is known per se, be pulled into the cage during transport, in order later to be pushed onto the respective connection means of the modules. The cage may be provided with connected-up support sections designed to be removed after the pipe coil has been connected to the installations . In the active operating state, the coil rests loosely on the inside floor of the cage. The occurring frictional forces are thereby known, making it unnecessary to oversize the pipe coil for the purpose of overcoming unknown frictional values. In use, the cage also serves as protection against external influences such as e.g. fishing equipment, and it may contain more than one pipe coil of the type in question. Any control piping connections (umbilical) may readily be connected along the pipe coil by means of techniques that are known per se.

Although the pipe coil according to the invention is primarily intended for use when connecting fixed installations, it is also well suited for forming a flexible connecting device for a rigid pipe. For such use, the pipe coil is connected between a rigid pipe and the fixed installation.

In use, there will be a point along the pipe coil at which there is little or no movement in the pipe. This point is well suited for connection of other pipes and any valves.

The following describes a non-limiting example of a preferred embodiment illustrated in the accompanying drawings, in which:

Figure 1 is a perspective view of a pipe coil according to the invention;

Figure 2 is a perspective view of the pipe coil of figure 1 placed in a cage structure; Figure 3 is a perspective view of the same as figure 2, but here the pipe coil is provided with a control cable connection and additional support from an extended cage structure; and

Figure 4 shows a section II-II of figure 2.

In the drawings, reference number 1 denotes a pipe coil comprising three essentially parallel lengths of piping 2, 4 and 6, where piping lengths 2 and 4 are located at a low level while piping length 6 is at a higher level. One end portion of each lowermost pipe 2, 4 is connected via a bend 8, 10 to a respective connecting pipe 12, 14, and the opposite end portion is connected to piping length 6 by means of bends 16 and 18, respectively, see figure 1.

The pipe couplings 19, 19' of connecting pipes 12, 14 are formed so as to match the connection point of an installation 20.

Preferably, the pipe coil 1 is arranged in a cage structure 22. In the operating state, the lower piping lengths 2, 4 rest freely on the inside floor of the cage 22. Normally, it is not necessary to brace the upper piping length 6 to the cage 22, as a result of the relatively short piping lengths in question. Figure 4 is a sectional view of the positioning of the pipe coil 1 in the cage 22.

In order to support the pipe coil 1 during fabrication, transport and tie-in, it may be expedient to provide the cage 22 with a cage extension 24 designed to form a supporting, detachable section. The cage 22 may be provided with one or two cage extensions 24. A control pipe connection 26 between the installations can be connected to the pipe coil 1, see figure 3.

When the pipe coil 1 is to be installed, it may be beneficial for the connecting pipes 12 and 14 to be retracted into the cage 22 in the manner shown by connecting pipe 14 in figure 2. Being able to move connecting pipes 12, 14 with coupling boxes 19, 19' out of the cage 22 during the connection operation facilitates the connection to the connecting means of an installation 20.

After the pipe coil 1 has been connected to the installations 20, the pipe coil may move freely in the cage 22, thereby absorbing any displacements that may occur.

It is obvious . that the use of a relatively short pipe coil 1 according to the invention, which may also be placed in a cage 22 with cage extensions 24, will simplify transport and lifting operations considerably when compared with similar operations carried out on long, e.g. Z-shaped pipe coils according to prior art.

Claims

C l a i m s

1. An arrangement at a pipe coil with connecting pipes, of the type used to interconnect fixed installations such

• as wells on the seabed, c h a r a c t e r i s e d i n that the pipe coil (1) comprises at least three essentially parallel lengths of piping (2, 4, 6).

2. An arrangement according to Claim 1, c h a r a c t e r i s e d i n that at least one length of piping (6) is located at a higher level than the remaining lengths of piping (2, 4) when the pipe coil (1) is in an operative state.

3. An arrangement according to one or more of the preceding claims, c h a r a c t e r i s e d i n that the connecting pipes (12, 14) of the pipe coil (1) project laterally relative to the longitudinal axis of the pipe coil (1).

4. An arrangement according to one or more of the preceding claims, c h a r a c t e r i s e d i n that the pipe coil (1) is placed wholly or partly inside a cage (22).

5. An arrangement according to one or more of the preceding claims, c h a r a c t e r i s e d i n that the connecting pipes (12, 14) and pipe couplings (19, 19') of the pipe coil (1) are connected to the cage (22).

6. An arrangement according to one or more of the preceding claims, c h a r a c t e r i s e d i n that the pipe coil (1) is placed wholly or partly in a cage (22) that may comprise several separate cage members.

7. An arrangement according to one or more of the preceding claims, c h a r a c t e r i s e d i n that the pipe coil (1) may in its active, connected state be moved freely in the cage (22).