WO2002081737A2 - Etat des encephalopathies spongiformes transmissibles - Google Patents

Etat des encephalopathies spongiformes transmissibles Download PDF

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Publication number
WO2002081737A2
WO2002081737A2 PCT/EP2002/003657 EP0203657W WO02081737A2 WO 2002081737 A2 WO2002081737 A2 WO 2002081737A2 EP 0203657 W EP0203657 W EP 0203657W WO 02081737 A2 WO02081737 A2 WO 02081737A2
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WO
WIPO (PCT)
Prior art keywords
sheep
disrupted
bse
preferable
scrapie
Prior art date
Application number
PCT/EP2002/003657
Other languages
English (en)
Other versions
WO2002081737A3 (fr
Inventor
Guenther Kinast
Antje Kinast
Original Assignee
Basilea Pharmaceutica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basilea Pharmaceutica Ag filed Critical Basilea Pharmaceutica Ag
Publication of WO2002081737A2 publication Critical patent/WO2002081737A2/fr
Publication of WO2002081737A3 publication Critical patent/WO2002081737A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/101—Bovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/103—Ovine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated

Definitions

  • TSEs Transmissible Spongiform Encephalopathies
  • Scrapie Perhaps the most widely recognized transmissible spongiform encephalopathy of animals is scrapie, which is a fatal progressive neurological disorder of sheep and goats. Scrapie has been reported in many countries and has been recognized in British sheep flocks for over two centuries, having been first recorded in 1732. Scrapie can be transmitted experimentally to several species, e.g., mink, cats, deer, moose, mice and hamsters.
  • BSE Bovine Spongiform Encephalopathy
  • Bovine spongiform encephalopathy (BSE), sometimes known as "mad cow disease”, was recognized as a potential member ofthe scrapie family of diseases as soon as it was discovered in November 1986. It shows all of he pathological characteristics of a transmissible spongiform encephalopathy.
  • BSE Bovine spongiform encephalopathy
  • Creutzfeldt-Jakob Disease in man uru Creutzfeldt-Jakob Disease and its more rare variant, the Gerstmann-Straussler- Scheinker disease, are examples of spongiform encephalopathies found in man. Like the animal disorders, they are progressive and universally fatal. Kuru was, at one time, common in certain tribes in New Guinea but has not been seen elsewhere.
  • PrPSc innocuous cellular proteins
  • mice with disrupted prions (PrPc) gene are healthy and do not get infected with BSE (Weissmann 1992) is concluded that prions (PrPc) do not exhibit essential physiological functions and genetic variances can be expected.
  • Serm from bulls and sheep from all over the world is collected and screened for disrupted prion genes by using the established methods for genotyping. Using sperm for genotyping has the advantage that sperm is easily accessible, easy to store and - in case of desired screening results - can be used for breeding directly.
  • the efficacy ofthe disrupted prion gene is tested by replacing the normal prion gene in lab animals - preferable mice and hamster - with the disrupted prion gene, breeding this lab animal and testing them for susceptibility of TSE infections by application of TSE-infected tissue - preferable brain tissue from BSE or Scrapie infected animals - to the bred cattle and sheep by oral, i.p., i.v., i.m., s.c, intracranial, and/or intracerebral routes, preferable intracranial and intracerebral routes.
  • TSE resistant animals are bred by inseminating female animals with disrupted prion gene sperm.
  • the success ofthe breeding process is monitored by analyzing the genome ofthe bred animals for the disrupted prion genes using the established methods for genotyping.
  • TSE-infected tissue - preferable brain tissue from BSE or Scrapie infected animals - is applied to the bred cattle and sheep by oral, i.p., i.v., i.m., s.c, intracranial, and/or intracerebral routes, preferable intracranial and intracerebral routes.
  • the describes process for breeding of BSE and Scrapie resistant animals has the advantage that natural BSE and Scrapie resistant cattle and sheep are obtained and transgenic knockout cattle and sheep (gene modified animals) are avoided.

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne le génotypage et l'analyse de sperme provenant de taureaux et de moutons pour trouver des gènes de prion fragmentés, ainsi que l'utilisation du sperme ainsi obtenu pour élever des bovins et des ovins résistants à l'ESB et à la tremblante du mouton. L'avantage du processus décrit est qu'il permet d'obtenir des bovins et des ovins naturels résistants à l'ESB et à la tremblante du mouton, et d'éviter des bovins et des ovins knock-out transgéniques (animaux génétiquement modifiés).
PCT/EP2002/003657 2001-04-06 2002-04-03 Etat des encephalopathies spongiformes transmissibles WO2002081737A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28189601P 2001-04-06 2001-04-06
US60/281,896 2001-04-06

Publications (2)

Publication Number Publication Date
WO2002081737A2 true WO2002081737A2 (fr) 2002-10-17
WO2002081737A3 WO2002081737A3 (fr) 2003-09-04

Family

ID=23079223

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/003657 WO2002081737A2 (fr) 2001-04-06 2002-04-03 Etat des encephalopathies spongiformes transmissibles

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WO (1) WO2002081737A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020146886A1 (fr) * 2019-01-11 2020-07-16 GlycoScience Research, Inc. Traitement d'une maladie neurodégénérative par le ganglioside gm1 de gangliosidose à gm1 d'ovin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998036059A2 (fr) * 1997-02-14 1998-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibition de la propagation d'un prion au moyen de mutants de proteine de prion a effet dominant-negatif
WO2001021835A2 (fr) * 1999-09-23 2001-03-29 Meat & Livestock Commission Procede servant a determiner la sensibilite a la tremblante chez les moutons

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998036059A2 (fr) * 1997-02-14 1998-08-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Inhibition de la propagation d'un prion au moyen de mutants de proteine de prion a effet dominant-negatif
WO2001021835A2 (fr) * 1999-09-23 2001-03-29 Meat & Livestock Commission Procede servant a determiner la sensibilite a la tremblante chez les moutons

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BANYKO GYORGY ET AL: "Identification of kappa-casein allele polymorphism by PCR and RFLP methods in the semen of bulls." MAGYAR ALLATORVOSOK LAPJA, vol. 50, no. 9, 1995, pages 553-556, XP001147792 ISSN: 0025-004X *
FERNANDO MEDRANO J ET AL: "Genotyping of bovine kappa-casein loci following DNA sequence amplification." BIO/TECHNOLOGY (NATURE PUBLISHING COMPANY) UNITED STATES FEB 1990, vol. 8, no. 2, February 1990 (1990-02), pages 144-146, XP008011171 ISSN: 0733-222X *
HUNTER NORA ET AL: "Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie." JOURNAL OF GENERAL VIROLOGY, vol. 74, no. 6, 1993, pages 1025-1031, XP009010040 ISSN: 0022-1317 *
ISHIGURO N ET AL: "RAPID ANALYSIS OF ALLELIC VARIANTS OF THE SHEEP PRP GENE BY OLIGONUCLEOTIDE PROBES" MICROBIOLOGY AND IMMUNOLOGY, TOKYO, JP, vol. 42, no. 8, 1998, pages 579-582, XP000992934 ISSN: 0385-5600 *
WEISSMANN CHARLES: "Molecular biology of transmissible spongiform encephalopathies." FEBS LETTERS, vol. 389, no. 1, 1996, pages 3-11, XP002239878 ISSN: 0014-5793 cited in the application *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020146886A1 (fr) * 2019-01-11 2020-07-16 GlycoScience Research, Inc. Traitement d'une maladie neurodégénérative par le ganglioside gm1 de gangliosidose à gm1 d'ovin
US11554130B2 (en) 2019-01-11 2023-01-17 GlycoScience Research, Inc. Treatment of neurodegenerative disease with ovine GM1 gangliosidosis GM1 ganglioside

Also Published As

Publication number Publication date
WO2002081737A3 (fr) 2003-09-04

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