WO2002081700A1 - Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives - Google Patents

Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives Download PDF

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Publication number
WO2002081700A1
WO2002081700A1 PCT/IB2001/000582 IB0100582W WO02081700A1 WO 2002081700 A1 WO2002081700 A1 WO 2002081700A1 IB 0100582 W IB0100582 W IB 0100582W WO 02081700 A1 WO02081700 A1 WO 02081700A1
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WO
WIPO (PCT)
Prior art keywords
protein
anyone
seq
bacteria
proteins
Prior art date
Application number
PCT/IB2001/000582
Other languages
English (en)
Inventor
Charles Jackson Thompson
Rowan Paul Morris
Original Assignee
Universität Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universität Basel filed Critical Universität Basel
Priority to PCT/IB2001/000582 priority Critical patent/WO2002081700A1/fr
Priority to PCT/IB2001/002336 priority patent/WO2002081699A1/fr
Publication of WO2002081700A1 publication Critical patent/WO2002081700A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/36—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinomyces; from Streptomyces (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)

Abstract

La présente invention concerne des protéines qui sont impliquées dans la résistance des bactéries gram-positives aux antibiotiques et leur utilisation pour l'identification de composés qui présentent un effet sur leur activité et/ou sur leur expression. Lesdites protéines peuvent être utilisées pour la production de bactéries surproduisant des antibiotiques ainsi que pour l'identification de composés qui inversent la résistance pléïotrope, évitent ou éliminent la tolérance et la persistance des bactéries.
PCT/IB2001/000582 2001-04-09 2001-04-09 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives WO2002081700A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/IB2001/000582 WO2002081700A1 (fr) 2001-04-09 2001-04-09 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives
PCT/IB2001/002336 WO2002081699A1 (fr) 2001-04-09 2001-12-07 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2001/000582 WO2002081700A1 (fr) 2001-04-09 2001-04-09 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives

Publications (1)

Publication Number Publication Date
WO2002081700A1 true WO2002081700A1 (fr) 2002-10-17

Family

ID=11004081

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/IB2001/000582 WO2002081700A1 (fr) 2001-04-09 2001-04-09 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives
PCT/IB2001/002336 WO2002081699A1 (fr) 2001-04-09 2001-12-07 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/002336 WO2002081699A1 (fr) 2001-04-09 2001-12-07 Proteines impliquees dans la resistance pleiotrope des bacteries gram-positives

Country Status (1)

Country Link
WO (2) WO2002081700A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332562A3 (fr) * 2009-04-09 2011-09-28 Universität zu Köln Agents thérapeutiques pour le traitement de la tuberculose, notamment la tuberculose pulmonaire

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL EBI; "Streptomyces coelicolor cosmid 23B6", XP002184468 *
DATABASE EMBL EBI; 29 January 1998 (1998-01-29), "M. tuberculosis H37Rv complete genome; segment 137/162", XP002184469 *
DATABASE SWALL EBI; 1 March 2001 (2001-03-01), "Putative DNA-binding protein of Streptomyces coelicolor", XP002184466 *
DATABASE SWALL EBI; 1 November 1996 (1996-11-01), "Putative transcriptional regulator WhiB7 of M. leprae", XP002184467 *
FOLCHER MARC ET AL: "A transcriptional regulator of a pristinamycin resistance gene in Streptomyces coelicolor.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 2, 12 January 2001 (2001-01-12), pages 1479 - 1485, XP002184465, ISSN: 0021-9258 *
KORMANEC JAN ET AL: "Streptomyces aureofaciens whiB gene encoding putative transcription factor essential for differentiation.", NUCLEIC ACIDS RESEARCH, vol. 21, no. 10, 1993, pages 2512, XP002184463, ISSN: 0305-1048 *
MOLLE VIRGINIE ET AL: "WhiD and WhiB, homologous proteins required for different stages of sporulation in Streptomyces coelicolor A3(2).", JOURNAL OF BACTERIOLOGY, vol. 182, no. 5, March 2000 (2000-03-01), pages 1286 - 1295, XP002184464, ISSN: 0021-9193 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2332562A3 (fr) * 2009-04-09 2011-09-28 Universität zu Köln Agents thérapeutiques pour le traitement de la tuberculose, notamment la tuberculose pulmonaire

Also Published As

Publication number Publication date
WO2002081699A1 (fr) 2002-10-17

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