WO2002081692A3 - Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof - Google Patents

Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof Download PDF

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Publication number
WO2002081692A3
WO2002081692A3 PCT/US2001/048543 US0148543W WO02081692A3 WO 2002081692 A3 WO2002081692 A3 WO 2002081692A3 US 0148543 W US0148543 W US 0148543W WO 02081692 A3 WO02081692 A3 WO 02081692A3
Authority
WO
WIPO (PCT)
Prior art keywords
transporter proteins
human transporter
nucleic acid
acid molecules
molecules encoding
Prior art date
Application number
PCT/US2001/048543
Other languages
French (fr)
Other versions
WO2002081692A2 (en
Inventor
Chunhua Yan
Weiniu Gan
Francesco Valentina Di
Ellen M Beasley
Gennady Merkulov
Original Assignee
Pe Corp Ny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Pe Corp Ny filed Critical Pe Corp Ny
Publication of WO2002081692A2 publication Critical patent/WO2002081692A2/en
Publication of WO2002081692A3 publication Critical patent/WO2002081692A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention provides amino acid sequences of peptides that encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
PCT/US2001/048543 2000-12-21 2001-12-19 Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof WO2002081692A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/741,153 US20020102637A1 (en) 2000-12-21 2000-12-21 Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
US09/741,153 2000-12-21

Publications (2)

Publication Number Publication Date
WO2002081692A2 WO2002081692A2 (en) 2002-10-17
WO2002081692A3 true WO2002081692A3 (en) 2003-08-21

Family

ID=24979610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/048543 WO2002081692A2 (en) 2000-12-21 2001-12-19 Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof

Country Status (2)

Country Link
US (2) US20020102637A1 (en)
WO (1) WO2002081692A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016199917A1 (en) 2015-06-12 2016-12-15 日本カーバイド工業株式会社 Image display device

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001053455A2 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
EP1130094A2 (en) * 1999-07-08 2001-09-05 Helix Research Institute Primers for synthesizing full length cDNA clones and their use
WO2002020754A2 (en) * 2000-09-05 2002-03-14 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
WO2002022684A2 (en) * 2000-09-15 2002-03-21 Incyte Genomics, Inc. Transporters and ion channels

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1130094A2 (en) * 1999-07-08 2001-09-05 Helix Research Institute Primers for synthesizing full length cDNA clones and their use
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001053455A2 (en) * 1999-12-23 2001-07-26 Hyseq, Inc. Novel nucleic acids and polypeptides
WO2002020754A2 (en) * 2000-09-05 2002-03-14 Incyte Genomics, Inc. Molecules for diagnostics and therapeutics
WO2002022684A2 (en) * 2000-09-15 2002-03-21 Incyte Genomics, Inc. Transporters and ion channels

Non-Patent Citations (14)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 16 March 1999 (1999-03-16), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "th91c06.x1 Soares_NSF_F8_9W_OT_PA_P_S1 Homo sapiens cDNA clone IMAGE:2126026 3' similar to TR:P70423 CATIONIC AMINO ACID TRANSPORTER; mRNA sequence", XP002236179, Database accession no. AI436660 *
DATABASE EMBL [online] 23 August 1999 (1999-08-23), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "wt28g03.x1 NCI_CGAP_Ut1 Homo sapiens cDNA clone IMAGE:2508820 3' similar to TR:P70423 AMINO ACID TRANSPORTER, CATIONIC 3; mRNA sequence", XP002236178, Database accession no. AI963203 *
DATABASE EMBL [online] 31 January 1997 (1997-01-31), HILLIER ET AL.: "zq67b10.s1 Stratagene neuroepithelium (#937231) Homo sapiens cDNA clone IMAGE:646651 3' similar to TR:G532612 HIGH-AFFINITY CATION AMINO ACID TRANSPORTER-1; mRNA sequence", XP002236181, Database accession no. AA205485 *
DATABASE EMBL [online] 5 March 1997 (1997-03-05), HILLIER ET AL.: "zr27e05.s1 Stratagene NT2 neuronal precursor 937230 Homo sapiens cDNA clone IMAGE:664640 3' similar t TR:G532612 HIGH-AFFINITY CATIONIC AMINO ACID TRANSPORTER-1; mRNA sequence", XP002236182, Database accession no. AA232266 *
DATABASE EMBL [online] 5 May 1999 (1999-05-05), NATIONAL CANCER INSTITUTE, CANCER GENOME ANATOMY PROJECT (CGAP): "tt48a09.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2243992 3' similar to TR:O08812 CATIONIC AMINO ACID TRANSPORTER 3; mRNA sequence", XP002236180, Database accession no. AI656849 *
DATABASE EMBL [online] ISOGAI T. ET AL.: "Homo sapiens cDNA FLJ14541 fis, clone NT2RM2001499, moderately similar to LOW-AFFINITY CATIONIC AMINO ACID TRANSPORTER-2", XP002236177, Database accession no. AK027447 *
HOSOKAWA HIROSHI ET AL: "Cloning and characterization of a brain-specific cationic amino acid transporter", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 272, no. 13, 1997, pages 8717 - 8722, XP002193512, ISSN: 0021-9258 *
ITO KENICHI ET AL: "A new member of the cationic amino acid transporter family is preferentially expressed in adult mouse brain.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 42, 1997, pages 26780 - 26786, XP002236176, ISSN: 0021-9258 *
N. VEKONY, S. WOLF, J.P. BOISSEL, E. I. CLOSS: "Human cationic aminoa cid transporter-3 (hCAT-3): cloning of a cDNA comprising the complete coding region and analysis of expression in diferent human tissues", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, vol. 361, no. suppl R5, 2000, XP001146763 *
SEBASTIO G ET AL: "A new gene (HCAT-3) displays high homology with human cationic amino acid transporters and maps to the critical region of the velocardiofacial syndrome.", AMERICAN JOURNAL OF HUMAN GENETICS, vol. 59, no. 4 SUPPL., 1996, 46th Annual Meeting of the American Society of Human Genetics;San Francisco, California, USA; October 29-November 2, 1996, pages A159, XP001121385, ISSN: 0002-9297 *
SPERANDEO MARIA PIA ET AL: "The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome.", GENOMICS, vol. 49, no. 2, 15 April 1998 (1998-04-15), pages 230 - 236, XP002236175, ISSN: 0888-7543 *
VEKONY N ET AL: "Cloning of a cDNA that codes for the human cationic amino acid transporter-3 (hCAT-3).", AMINO ACIDS (VIENNA), vol. 17, no. 1, 1999, 6th International Congress on Amino Acids;Bonn, Germany; August 3-7, 1999, pages 45 - 46, XP009008499, ISSN: 0939-4451 *
VEKONY N ET AL: "EXPRESSION AND TRANSPORT PROPERTIES OF THE HUMAN CATIONIC AMINO ACID TRANSPORTER-3 (HCAT-3)", NAUNYN-SCHMIEDEBERG'S ARCHIVES OF PHARMACOLOGY, SPRINGER, BERLIN, DE, vol. 363, no. SUPPL 4, 13 March 2001 (2001-03-13), pages R07, XP001063316, ISSN: 0028-1298 *
VEKONY NICOLE ET AL: "Human cationic amino acid transporter hCAT-3 is preferentially expressed in peripheral tissues", BIOCHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, PA, US, vol. 40, no. 41, 16 October 2001 (2001-10-16), pages 12387 - 12394, XP002193513, ISSN: 0006-2960 *

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US20020102637A1 (en) 2002-08-01
WO2002081692A2 (en) 2002-10-17
US20030143689A1 (en) 2003-07-31

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