WO2002079492A8 - Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators - Google Patents

Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators

Info

Publication number
WO2002079492A8
WO2002079492A8 PCT/US2002/004915 US0204915W WO02079492A8 WO 2002079492 A8 WO2002079492 A8 WO 2002079492A8 US 0204915 W US0204915 W US 0204915W WO 02079492 A8 WO02079492 A8 WO 02079492A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
angiogenesis
diagnosis
screening
compositions
Prior art date
Application number
PCT/US2002/004915
Other languages
French (fr)
Other versions
WO2002079492A2 (en
Inventor
Richard Murray
Richard Glynne
Susan R Watson
Natasha Aziz
Original Assignee
Protein Design Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Protein Design Labs Inc filed Critical Protein Design Labs Inc
Priority to CA002438030A priority Critical patent/CA2438030A1/en
Priority to AU2002257004A priority patent/AU2002257004A1/en
Priority to EP02726581A priority patent/EP1418943A1/en
Priority to JP2002578493A priority patent/JP2004531249A/en
Publication of WO2002079492A2 publication Critical patent/WO2002079492A2/en
Publication of WO2002079492A8 publication Critical patent/WO2002079492A8/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57449—Specifically defined cancers of ovaries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/US2002/004915 2001-02-14 2002-02-14 Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators WO2002079492A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002438030A CA2438030A1 (en) 2001-02-14 2002-02-14 Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
AU2002257004A AU2002257004A1 (en) 2001-02-14 2002-02-14 Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
EP02726581A EP1418943A1 (en) 2001-02-14 2002-02-14 Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators
JP2002578493A JP2004531249A (en) 2001-02-14 2002-02-14 Method for diagnosing angiogenesis, composition, and method for screening angiogenesis modulator

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US78435601A 2001-02-14 2001-02-14
US09/784,356 2001-02-14
US79139001A 2001-02-22 2001-02-22
US09/791,390 2001-02-22
US28547501P 2001-04-19 2001-04-19
US60/285,475 2001-04-19
US31002501P 2001-08-03 2001-08-03
US60/310,025 2001-08-03
US35066601P 2001-11-13 2001-11-13
US60/350,666 2001-11-13
US33424401P 2001-11-29 2001-11-29
US60/334,244 2001-11-29

Publications (2)

Publication Number Publication Date
WO2002079492A2 WO2002079492A2 (en) 2002-10-10
WO2002079492A8 true WO2002079492A8 (en) 2004-03-25

Family

ID=27559580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/004915 WO2002079492A2 (en) 2001-02-14 2002-02-14 Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators

Country Status (5)

Country Link
EP (1) EP1418943A1 (en)
JP (1) JP2004531249A (en)
AU (1) AU2002257004A1 (en)
CA (1) CA2438030A1 (en)
WO (1) WO2002079492A2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030114410A1 (en) 2000-08-08 2003-06-19 Technion Research And Development Foundation Ltd. Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis
AU2002249787A1 (en) 2000-10-25 2002-08-19 Diadexus, Inc. Compositions and methods relating to lung specific genes and proteins
US7622443B2 (en) 2002-04-26 2009-11-24 California Institute Of Technology Method for inhibiting pro-angiogenic activities of endothelial cells selectively at a site of neoangiogenesis in a mammal by administration of the extracellular domain of D1-1 polypeptides
WO2003091447A2 (en) 2002-04-26 2003-11-06 California Institute Of Technology D1-1 nucleic acids, polypeptides and related methods
DE60335636D1 (en) * 2002-09-11 2011-02-17 Genentech Inc COMPOSITIONS AND METHODS FOR TUMOR DIAGNOSIS AND TREATMENT
US7276589B2 (en) 2002-11-26 2007-10-02 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
US7285268B2 (en) 2002-11-26 2007-10-23 Pdl Biopharma, Inc. Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis
EP2060918A3 (en) 2003-04-01 2009-08-26 The Johns Hopkins University Breast endothelial cell expression patterns
ATE494550T1 (en) 2003-04-25 2011-01-15 Takeda Pharmaceutical NEW SCREENING PROCESS
US7267950B2 (en) * 2003-05-01 2007-09-11 Veridex, Lcc Rapid extraction of RNA from cells and tissues
WO2004109286A2 (en) * 2003-06-09 2004-12-16 The University Of British Columbia Methods for detecting and treating cancer using podocalyxin and/or endoglycan
US9309323B2 (en) 2003-06-09 2016-04-12 The University Of British Columbia Methods for detecting and treating cancer
JP2007527704A (en) * 2003-06-30 2007-10-04 ジェノバ・リミテッド Secreted polypeptide species associated with cardiovascular disorders
US7485297B2 (en) 2003-08-12 2009-02-03 Dyax Corp. Method of inhibition of vascular development using an antibody
DE10340373A1 (en) * 2003-08-30 2005-03-24 Henkel Kgaa Determining the hair cycle in humans, by measuring protein or mRNA levels and classification as anagenic or catagenic, also for screening therapeutic or cosmetic agents that affect hair growth
JP2005073621A (en) * 2003-09-01 2005-03-24 Japan Science & Technology Agency Marker for cerebral tumor and method for diagnosing cerebral tumor
EP1721158A4 (en) * 2004-01-13 2008-07-30 Rigel Pharmaceuticals Inc Modulators of angiogenesis
KR20070009637A (en) 2004-03-24 2007-01-18 피디엘 바이오파르마 인코포레이티드 Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation
US7781175B2 (en) 2004-04-23 2010-08-24 Takeda Pharmaceutical Company Limited Method of screening compounds which alter the binding properties of GPR39, and homologs thereof, to bile acid
WO2005113788A2 (en) * 2004-05-21 2005-12-01 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled receptor kinase 6 (grk6)
EP2182078B1 (en) * 2005-09-01 2012-02-01 Bristol-Myers Squibb Company Biomarkers and methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
JP2009526861A (en) * 2006-02-14 2009-07-23 ゲイシンガー クリニック GPCR as an angiogenic target
WO2007096142A2 (en) * 2006-02-22 2007-08-30 Philogen Spa Vascular tumor markers
BRPI0709338A2 (en) 2006-03-21 2011-07-12 Genentech Inc antibody, isolated nucleic acid molecule, cell, compositions, alpha5beta1 protein detection method, antibody use, treatment methods, kit, use of a composition, use of an alpha5beta antagonist, and use of a vegf antagonist
SI2200700T1 (en) 2007-09-26 2016-04-29 Genentech, Inc. Novel antibodies
EP2216399A1 (en) * 2009-01-30 2010-08-11 Université de la Méditerranée Human soluble CD146, preparation and uses thereof
MX2011010012A (en) 2009-03-25 2011-12-06 Genentech Inc Novel anti-î+-5î²1 antibodies and uses thereof.
WO2010144358A1 (en) 2009-06-08 2010-12-16 Singulex, Inc. Highly sensitive biomarker panels
JP5868176B2 (en) 2009-07-08 2016-02-24 株式会社ＡＣＴＧｅｎ Antibody having anticancer activity
JP5962996B2 (en) * 2009-09-03 2016-08-03 キャンサー・リサーチ・テクノロジー・リミテッド CLEC14A inhibitor

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9182405B2 (en) 2006-04-04 2015-11-10 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9494598B2 (en) 2006-04-04 2016-11-15 Singulex, Inc. Highly sensitive system and method for analysis of troponin
US9176139B2 (en) 2007-08-02 2015-11-03 Gilead Biologics, Inc. LOX and LOXL2 inhibitors and uses thereof
US9107935B2 (en) 2009-01-06 2015-08-18 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US9289447B2 (en) 2009-01-06 2016-03-22 Gilead Biologics, Inc. Chemotherapeutic methods and compositions
US8927700B2 (en) 2009-08-21 2015-01-06 Gilead Biologics, Inc. Catalytic domains from lysyl oxidase and LOXL2

Also Published As

Publication number Publication date
WO2002079492A2 (en) 2002-10-10
EP1418943A1 (en) 2004-05-19
JP2004531249A (en) 2004-10-14
AU2002257004A1 (en) 2002-10-15
CA2438030A1 (en) 2002-10-10

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