WO2002079240A3 - Intimins for the prevention or treatment of infections: i - Google Patents

Intimins for the prevention or treatment of infections: i Download PDF

Info

Publication number
WO2002079240A3
WO2002079240A3 PCT/GB2002/001447 GB0201447W WO02079240A3 WO 2002079240 A3 WO2002079240 A3 WO 2002079240A3 GB 0201447 W GB0201447 W GB 0201447W WO 02079240 A3 WO02079240 A3 WO 02079240A3
Authority
WO
WIPO (PCT)
Prior art keywords
intimin
fragment
polypeptides
polypeptide
combination
Prior art date
Application number
PCT/GB2002/001447
Other languages
French (fr)
Other versions
WO2002079240A2 (en
Inventor
Gadi Frankel
Gordon Dougan
Original Assignee
Imp College Innovations Ltd
Gadi Frankel
Gordon Dougan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0107837A external-priority patent/GB0107837D0/en
Priority claimed from GB0107840A external-priority patent/GB0107840D0/en
Application filed by Imp College Innovations Ltd, Gadi Frankel, Gordon Dougan filed Critical Imp College Innovations Ltd
Priority to EP02720132A priority Critical patent/EP1372709A2/en
Priority to AU2002251202A priority patent/AU2002251202A1/en
Publication of WO2002079240A2 publication Critical patent/WO2002079240A2/en
Publication of WO2002079240A3 publication Critical patent/WO2002079240A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Abstract

A pharmaceutical composition, vaccine, food product or kit of parts comprising a polypeptide or polypeptides and/or polynucleotide or polynucleotides in combination comprising or encoding a polypeptide or polypeptides in combination comprising at least two of (1) α-intimin or a fragment thereof, (2) β-intimin or a fragment thereof, (3) Ϝ-intimin or a fragment thereof, (4) δ-intimin or a fragment thereof, and (5) ϵ-intimin or a fragment thereof, together with a pharmaceutically acceptable diluent or carrier, wherein the polypeptide or polypeptides do not consist of the Gly387 to Lys66 region, or a fragment thereof, of two or more intimins. Vaccination with the Gly387 to Lys666 region, which is conserved between different intimin types, is not considered to confer protective immunity. A combination vaccine may provide such protective immunity and may be useful in providing protection against bacterial infection.
PCT/GB2002/001447 2001-03-29 2002-03-26 Intimins for the prevention or treatment of infections: i WO2002079240A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02720132A EP1372709A2 (en) 2001-03-29 2002-03-26 Intimins for the prevention or treatment of infections: i
AU2002251202A AU2002251202A1 (en) 2001-03-29 2002-03-26 Intimins for the prevention or treatment of infections: i

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0107840.1 2001-03-29
GB0107837.7 2001-03-29
GB0107837A GB0107837D0 (en) 2001-03-29 2001-03-29 Biological materials and methods for use in the prevention or treatment of infections:II
GB0107840A GB0107840D0 (en) 2001-03-29 2001-03-29 Biological materials and methods for use in the prevention or treatment of infections:I

Publications (2)

Publication Number Publication Date
WO2002079240A2 WO2002079240A2 (en) 2002-10-10
WO2002079240A3 true WO2002079240A3 (en) 2003-06-26

Family

ID=26245909

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/GB2002/001462 WO2002079247A2 (en) 2001-03-29 2002-03-26 Intimins in the prevention or treatment of infections:ii
PCT/GB2002/001447 WO2002079240A2 (en) 2001-03-29 2002-03-26 Intimins for the prevention or treatment of infections: i

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001462 WO2002079247A2 (en) 2001-03-29 2002-03-26 Intimins in the prevention or treatment of infections:ii

Country Status (3)

Country Link
EP (1) EP1372709A2 (en)
AU (2) AU2002241162A1 (en)
WO (2) WO2002079247A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1305525C (en) * 2004-03-27 2007-03-21 中国人民解放军第三军医大学 0157 bacterium gene engineering multivalence subunit vaccine of human and sensitive animals and its preparing method
GB2473523A (en) * 2009-09-10 2011-03-16 Solus Scient Solutions Ltd Nalidixic acid and lithium in a base medium for the culture of Listeria
CN103212060B (en) * 2013-04-23 2014-11-05 中国人民解放军军事医学科学院微生物流行病研究所 Application of protein and composition thereof in preparation of product used for preventing, diagnosing or treating EHEC (Enterohemorrhagic Escherichia Coli) infection
CN105821065A (en) * 2016-04-29 2016-08-03 南方医科大学 Double-antigen recombinant protein and preparation method and application thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040161A1 (en) * 1996-04-19 1997-10-30 Henry M. Jackson Foundation For The Advancement Of Military Medecine Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
WO1997040177A1 (en) * 1996-04-19 1997-10-30 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
WO1999041614A2 (en) * 1998-02-16 1999-08-19 Imperial College Of Science, Technology And Medicine Method for detecting intimin producing microorganisms
WO2000045173A1 (en) * 1999-01-29 2000-08-03 Imperial College Innovations Limited Inhibitors of intimin adhesion and tests for their screening
WO2002053181A1 (en) * 2001-01-04 2002-07-11 University Of Saskatchewan Enterohemorragic escherichia coli vaccine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997040161A1 (en) * 1996-04-19 1997-10-30 Henry M. Jackson Foundation For The Advancement Of Military Medecine Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
WO1997040177A1 (en) * 1996-04-19 1997-10-30 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens
WO1999041614A2 (en) * 1998-02-16 1999-08-19 Imperial College Of Science, Technology And Medicine Method for detecting intimin producing microorganisms
WO2000045173A1 (en) * 1999-01-29 2000-08-03 Imperial College Innovations Limited Inhibitors of intimin adhesion and tests for their screening
WO2002053181A1 (en) * 2001-01-04 2002-07-11 University Of Saskatchewan Enterohemorragic escherichia coli vaccine

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GANSHEROFF L J ET AL: "Decreased adherence of enterohemorrhagic Escherichia coli to HEp-2 cells in the presence of antibodies that recognize the C-terminal region of intimin.", INFECTION AND IMMUNITY, vol. 67, no. 12, December 1999 (1999-12-01), pages 6409 - 6417, XP002234422, ISSN: 0019-9567 *
GHAEM-MAGHAMI M ET AL: "Intimin-specific immune responses prevent bacterial colonization by the attaching-effacing pathogen Citrobacter rodentium.", INFECTION AND IMMUNITY, vol. 69, no. 9, September 2001 (2001-09-01), pages 5597 - 5605, XP001117554, ISSN: 0019-9567 *

Also Published As

Publication number Publication date
EP1372709A2 (en) 2004-01-02
AU2002251202A1 (en) 2002-10-15
AU2002241162A1 (en) 2002-10-15
WO2002079247A3 (en) 2003-10-30
WO2002079240A2 (en) 2002-10-10
WO2002079247A2 (en) 2002-10-10

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