WO2002079223A3 - Covalently reactive transition state analogs and methods of use thereof - Google Patents

Covalently reactive transition state analogs and methods of use thereof Download PDF

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Publication number
WO2002079223A3
WO2002079223A3 PCT/US2002/010116 US0210116W WO02079223A3 WO 2002079223 A3 WO2002079223 A3 WO 2002079223A3 US 0210116 W US0210116 W US 0210116W WO 02079223 A3 WO02079223 A3 WO 02079223A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
transition state
state analogs
covalently reactive
reactive transition
Prior art date
Application number
PCT/US2002/010116
Other languages
French (fr)
Other versions
WO2002079223A2 (en
WO2002079223A9 (en
Inventor
Sudhir Paul
Yasuhiro Nishiyama
Original Assignee
Univ Texas
Sudhir Paul
Yasuhiro Nishiyama
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas, Sudhir Paul, Yasuhiro Nishiyama filed Critical Univ Texas
Priority to EP02757911A priority Critical patent/EP1373307A4/en
Priority to CA002442693A priority patent/CA2442693A1/en
Publication of WO2002079223A2 publication Critical patent/WO2002079223A2/en
Publication of WO2002079223A9 publication Critical patent/WO2002079223A9/en
Publication of WO2002079223A3 publication Critical patent/WO2002079223A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed.
PCT/US2002/010116 2001-03-31 2002-04-01 Covalently reactive transition state analogs and methods of use thereof WO2002079223A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02757911A EP1373307A4 (en) 2001-03-31 2002-04-01 Covalently reactive transition state analogs and methods of use thereof
CA002442693A CA2442693A1 (en) 2001-03-31 2002-04-01 Covalently reactive transition state analogs and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28062401P 2001-03-31 2001-03-31
US60/280,624 2001-03-31

Publications (3)

Publication Number Publication Date
WO2002079223A2 WO2002079223A2 (en) 2002-10-10
WO2002079223A9 WO2002079223A9 (en) 2003-01-09
WO2002079223A3 true WO2002079223A3 (en) 2003-07-24

Family

ID=23073896

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/010116 WO2002079223A2 (en) 2001-03-31 2002-04-01 Covalently reactive transition state analogs and methods of use thereof

Country Status (3)

Country Link
EP (1) EP1373307A4 (en)
CA (1) CA2442693A1 (en)
WO (1) WO2002079223A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087059A2 (en) * 2003-03-26 2004-10-14 The University Of Texas Covalent attachment of ligands to nucleophilic proteins guided by non-covalent binding
JP4939929B2 (en) * 2003-03-26 2012-05-30 ポール，サッドヒル Proteolytic and covalent antibodies

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952462A (en) * 1983-11-29 1999-09-14 Igen International Inc. Transition state analogs

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235714B1 (en) * 1998-03-23 2001-05-22 Sudhir Paul Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952462A (en) * 1983-11-29 1999-09-14 Igen International Inc. Transition state analogs

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
GAO Q.-S. ET AL.: "Site-directed mutagenesis of proteolytic antibody light chain", J. MOL. BIOL., vol. 253, 1995, pages 658 - 664, XP002963389 *
HIRSCHMANN R. ET AL.: "Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids", SCIENCE, vol. 265, 8 July 1994 (1994-07-08), pages 234 - 237, XP002963390 *
RAHIL J. ET AL.: "Characterization of covalently bound enzyme inhibitors as transition-state analogs by protein stability measurements: phosphonate monoester inhibitors of a beta-lactamase", BIOCHEM., vol. 33, 1994, pages 116 - 125, XP002963391 *
See also references of EP1373307A4 *
TRAMONTANO: "Immune recognition, antigen design and catalytic antibody production", APPL. BIOCHEM. BIOTECH., vol. 47, 1994, pages 257 - 275, XP002963388 *

Also Published As

Publication number Publication date
WO2002079223A2 (en) 2002-10-10
CA2442693A1 (en) 2002-10-10
EP1373307A2 (en) 2004-01-02
WO2002079223A9 (en) 2003-01-09
EP1373307A4 (en) 2006-01-25

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