WO2002079147B1 - Inhibitors of prenyl-protein transferase - Google Patents

Inhibitors of prenyl-protein transferase

Info

Publication number
WO2002079147B1
WO2002079147B1 PCT/US2002/009213 US0209213W WO02079147B1 WO 2002079147 B1 WO2002079147 B1 WO 2002079147B1 US 0209213 W US0209213 W US 0209213W WO 02079147 B1 WO02079147 B1 WO 02079147B1
Authority
WO
WIPO (PCT)
Prior art keywords
unsubstituted
prenyl
substituted
protein transferase
inhibitors
Prior art date
Application number
PCT/US2002/009213
Other languages
French (fr)
Other versions
WO2002079147A3 (en
WO2002079147A2 (en
Inventor
S Jane Desolms
Anthony W Shaw
Original Assignee
Merck & Co Inc
S Jane Desolms
Anthony W Shaw
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, S Jane Desolms, Anthony W Shaw filed Critical Merck & Co Inc
Priority to AU2002254375A priority Critical patent/AU2002254375A1/en
Publication of WO2002079147A2 publication Critical patent/WO2002079147A2/en
Publication of WO2002079147A3 publication Critical patent/WO2002079147A3/en
Publication of WO2002079147B1 publication Critical patent/WO2002079147B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present invention is directed to compounds which inhibit prenyl-protein transferase (FTase) and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

Claims

AMENDED CLAIMS
[Received by the International Bureau on 14 January 2003( 14.01.03): original claim 2 replaced by amended claim 2 (1 page)]
Z is selected from: a) aryl, b) heterocycle, and c) Cs-C ιo cycloalkyl;
m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; p is l or 2; q is 0, 1 or 2; r is 0, 1, 2, 3, or 4; s is 0, 1, 2, 3 or 4; t is 0, 1, 2 or 3;
or a pharmaceutically acceptable salt, an optical isomer or stereoisomer thereof.
2. The compound according to Claim 1, as illustrated by formula B:
Figure imgf000002_0001
wherein:
Rla is independently selected from: a) hydrogen, b) unsubstituted or substituted aryl, c) unsubstituted or substituted heterocycle, d) unsubstituted or substituted C3-C10 cycloalkyl, e) unsubstituted or substituted C2- . alkenyl, f) unsubstituted or substituted C2-C6 alkynyl,
PCT/US2002/009213 2001-03-30 2002-03-26 Inhibitors of prenyl-protein transferase WO2002079147A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002254375A AU2002254375A1 (en) 2001-03-30 2002-03-26 Inhibitors of prenyl-protein transferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28060901P 2001-03-30 2001-03-30
US60/280,609 2001-03-30

Publications (3)

Publication Number Publication Date
WO2002079147A2 WO2002079147A2 (en) 2002-10-10
WO2002079147A3 WO2002079147A3 (en) 2003-04-24
WO2002079147B1 true WO2002079147B1 (en) 2003-07-03

Family

ID=23073826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/009213 WO2002079147A2 (en) 2001-03-30 2002-03-26 Inhibitors of prenyl-protein transferase

Country Status (2)

Country Link
AU (1) AU2002254375A1 (en)
WO (1) WO2002079147A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE398612T1 (en) * 2004-05-03 2008-07-15 Janssen Pharmaceutica Nv DIASTEREOSELECTIVE ADDITION OF LITHIATED N-METHYLIMIDAZOLE TO SULFINIMINE
DE602005021878D1 (en) * 2004-05-03 2010-07-29 Janssen Pharmaceutica Nv DIASTERE ELECTIVE SYNTHESIS PROCESS WITH 6-BROMO-4- (3-CHLOROPHENYL) -2-METHOXYCHINOLINE
WO2010114896A1 (en) 2009-03-31 2010-10-07 Arqule, Inc. Substituted indolo-pyridinone compounds
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
CA3106239A1 (en) 2018-07-27 2020-01-30 Biotheryx, Inc. Bifunctional compounds as cdk modulators
US11897930B2 (en) 2020-04-28 2024-02-13 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2477400A (en) * 1998-12-08 2000-06-26 Merck & Co., Inc. Inhibitors of prenyl-protein transferase

Also Published As

Publication number Publication date
WO2002079147A3 (en) 2003-04-24
WO2002079147A2 (en) 2002-10-10
AU2002254375A1 (en) 2002-10-15

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