Classifications

• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
  • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
  • G01T1/16—Measuring radiation intensity
  • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
  • G01T1/164—Scintigraphy
  • G01T1/1641—Static instruments for imaging the distribution of radioactivity in one or two dimensions using one or several scintillating elements; Radio-isotope cameras
  • G01T1/1648—Ancillary equipment for scintillation cameras, e.g. reference markers, devices for removing motion artifacts, calibration devices
• • G—PHYSICS
  • G01—MEASURING; TESTING
  • G01T—MEASUREMENT OF NUCLEAR OR X-RADIATION
  • G01T1/00—Measuring X-radiation, gamma radiation, corpuscular radiation, or cosmic radiation
  • G01T1/16—Measuring radiation intensity
  • G01T1/161—Applications in the field of nuclear medicine, e.g. in vivo counting
  • G01T1/164—Scintigraphy
  • G01T1/1641—Static instruments for imaging the distribution of radioactivity in one or two dimensions using one or several scintillating elements; Radio-isotope cameras
  • G01T1/1644—Static instruments for imaging the distribution of radioactivity in one or two dimensions using one or several scintillating elements; Radio-isotope cameras using an array of optically separate scintillation elements permitting direct location of scintillations
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
  • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
  • A61B6/02—Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
  • A61B6/03—Computed tomography [CT]
  • A61B6/037—Emission tomography

Definitions

• the present invention relates to the diagnostic imaging arts. It finds particular application in conjunction with SPECT nuclear imaging systems and will be described with particular reference thereto. It will be appreciated, however, that the present invention is useful in conjunction with other systems that utilize collimated detectors to detect penetrating radiation, and is not limited to the aforementioned application.
• a source of radioactivity is used to provide non-invasive diagnostic images.
• the source is typically injected into a patient, although external sources are also utilized. Radiation from the source traverses at least a portion of the patient and is detected by radiation detectors.
• a nuclear camera has one, two, or three detector heads.
• ROLEC rotating laminar emission cameras
• a one-dimensional detector array or line of detectors is rotated in each head. Collimator vanes which are mounted between the detectors of the array rotate with the detector array.
• the one-dimensional collimation results in a plane integral reconstruction as opposed to a line integral reconstruction, as is typical in most Anger camera systems.
• the detector In a system collimated in one dimension, the detector "sees" that is, receives radiation from, a plane. In a typical Anger camera with two dimensional collimation, each collimated element of the detector sees a line of the imaging volume. Moreover, described more accurately, the typical ROLEC produces only an approximation of a planar integral . In actuality, the plane integral should have a weighting factor included therein in order to compensate for a l/r dependence to an object being imaged, where r represents the distance of a detectable radiation event to the detector. All other things being equal, the detector is more sensitive to relatively close objects, and is less sensitive to relatively distant objects. Typically, previously developed ROLECs ignore the l/r weighting, accepting that the detected information is an approximation. Ultimately, failure to model the dependence, or improper modeling of the dependence reduces resultant image quality.
• the parallel collimator vanes can be skewed a few degrees from perpendicular.
• a pair of corresponding data sets are generated whose planes are offset by a very small but known angle. This relationship enables the l/r dependency to be reduced to a trigonometric function of the angle, which is a constant.
• these relationships were limited to substantially parallel collimator geometries.
• data from magnifying (converging) collimators and minifying (diverging) collimators could not be reconstructed accurately.
• the present invention provides a new and improved method and apparatus that overcomes the above referenced problems and others .
• a method of nuclear imaging is provided.
• a detector array and a convergent or divergent collimator are rotated about a detector axis of rotation and around a longitudinal axis of a subject. Radiation from the subject is converted into electrical signals which are reconstructed to form a magnified image representation.
• a diagnostic imaging apparatus is provided.
• a detector head that includes a linear array of detector elements and a magnifying collimator is mounted for movement about an axis of a subject.
• a means rotates the array around a detector axis of rotation.
• a reconstruction means reconstructs signals from the detector into an image representation.
• One advantage of the present invention resides in a magnifying detector assembly.
• Another advantage resides in sub-millimeter resolution.
• Another advantage of the present invention is that it presents a small, relatively light nuclear detector array.
• Yet another advantage is that it presents a solid state nuclear detector array.
• FIGURE 1 is a diagrammatic illustration of a nuclear imaging device in accordance with the present invention
• FIGURE 2 is a perspective view of a detector array and collimator arrangement in accordance with the present invention
• FIGURE 3 is an illustration of a convergent collimated detector array, its field of view, and its focal spot, in accordance with the present invention
• FIGURE 4A is an illustration of the collimated detector array, with all of the collimator slats shifted by a uniform angle;
• FIGURE 4B is a close-up view of one of the shifted collimators slats, displaced by an angle ⁇ ;
• FIGURE 5 is an illustration of an action of tilting the detector array to obtain parallel views of the field of view.
• FIGURE 6A is one preferred path of a magnifying collimator focal spot about a longitudinal axis of a patient
• FIGURE 6B is another preferred path of the focal spot about the longitudinal axis
• FIGURE 7 is a perspective view of local coordinate systems, a cylindrical system in r, , and ⁇ , and a Cartesian system in u, v, and ⁇ .
• a region of interest of a subject 10 is disposed in an imaging region 12.
• a radiopharmaceutical 14 is injected into the subject, near a region to be imaged. For example, if a physician wants to view a blockage in the aorta, the isotope is injected into the bloodstream upstream from the blockage. As another example, the radiopharmaceutical 14 is injected into the circulatory system and its selective absorption by tissue of interest is monitored.
• Atomic nuclei of the radioactive isotope decay over time. Energy is released at the time of decay in the form of a radiation photon, more specifically, a ⁇ -ray of characteristic energy. Many of the ⁇ -rays produced during an imaging process are lost, propagating in useless directions. However, some of the ⁇ -rays pass through a collimator 16, thin
• the slats of the collimator 16 in a magnifying embodiment are angled to converge on a focal point 40 in front of the detector.
• the magnifying collimator geometry uses the entire length of the detector array 18 to image a field of view 42 much smaller than itself. For example, if the detector array 18 has a length of 40 cm, and the field of view 42 has a length of 4 cm, then the field of view 42 will be imaged at ten times its normal size, that is, it will be magnified.
• the slats of the collimator 16 are tilted by an angle ⁇ from the convergent position described previously.
• the tilted collimator slats 16a converge on a shifted focal point
• the angle a is greater than zero degrees and less than or equal to 5 degrees. Preferably, the angle is approximately 0.29°, but is adjusted during machine setup for optimal results in each physical environment.
• the corresponding data sets collected 180° of detector rotation apart are not identical.
• the first motion is a rotation of the detector array 18 about the axis 34 of the head 30.
• the second range of motion is a rotation of the head about the subject 10.
• the detector array 18 is mounted on the axis 34, perpendicular to the longitudinal axis 36, with the axis 34 intersecting a center of the detector array 18.
• the array 18 is rotated by a motor speed control 44 about the axis, preferably through several rotations that are averaged to generate a single "SPECT view" of the subject 10.
• the first motion is preferably continuous, completing 360° of rotation (or multiples thereof) without stopping.
• the detector rotation is preferably performed while the head 30 is stationary, that is, it is performed at a single "SPECT angle" 50, from a single spot on the gantry for simplicity of explanation and data processing. However, continuous rotation of the head around the longitudinal axis produces mathematically equivalent data.
• the rotation of the detector generates planar projection images .
• a mechanized drive moves the head 30 around the longitudinal axis, stopping at each of a plurality of the SPECT angles or sampling positions 50.
• the head 30 preferably traverses 180° around the subject for a single imaging cycle.
• each SPECT angle 50 is separated from the next by 3°, that is, there are preferably 60 SPECT sampling angles in 180°.
• the head 30 stops long enough for the detector to rotate 360°.
• valid decay events are determined by an event analyzer 52.
• Valid events are sorted 54 and classified by a dual-energy study, or the like.
• ⁇ is the small angle between the focal point 40 and one of the focal points 40a and 40a' .
• Equation (1) can also be expressed as:
• f [f (r, a r a) r dr da is the Radon transform.
• the Radon inversion formula reconstructs the image f by backprojecting the second derivative of the Radon d 2 r transform, i . e . , by backproj ecting — - I / f " ( r, ⁇ , ⁇ ) r dr d ⁇ . ⁇ J
• the detector is not just rotated about its longitudinal axis, but is also wobbled. That is, the detector head is rotated at each of three angular offsets, in the preferred embodiment to create three sets of planes of first derivative data 64. These planes are sorted 66 into parallel planes.
• a second derivative processor 68 evaluates the parallel planes of first derivative data to generate a second derivative.
• a backproj ector 70 backprojects the data in accordance with the Radon inversion formula into a volume image memory 72.
• An image processor 74 processes selected portions of the volumetric image representation to generate slice, three-dimensional rendering, projection, and other image representations as may be requested by the operator for display on a human-readable display 76 such as a computer monitor, LCD display, active matrix monitor, or the like.
• the tipping action may be accomplished in various modes.
• the head rotates continuously around the longitudinal axis of the subject while the detector head wobbles, such that the focal spot follows a generally sinusoidal trajectory 80.
• the detector is wobbled at the starting point to create vertical movement of the focal spot 82.
• the detector head is then rotated without wobbling even in steps or continuously, such that the focal spot moves along trajectory 84, either continuously or in steps.
• the detector head is again wobbled to move the focal spot along a second vertical path 86.
• the collimator 16 is a divergent collimator making the viewable field of the detector array 18 larger than the array itself, producing a minimizing effect in the reconstructed image.
• the focal spot 40 in such a system would be behind the detector.

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• Physics & Mathematics (AREA)
• Health & Medical Sciences (AREA)
• Engineering & Computer Science (AREA)
• Biomedical Technology (AREA)
• General Health & Medical Sciences (AREA)
• Medical Informatics (AREA)
• Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
• Optics & Photonics (AREA)
• Life Sciences & Earth Sciences (AREA)
• General Physics & Mathematics (AREA)
• High Energy & Nuclear Physics (AREA)
• Molecular Biology (AREA)
• Spectroscopy & Molecular Physics (AREA)
• Nuclear Medicine (AREA)

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• 2001
  • 2001-03-15 US US09/808,935 patent/US6627893B1/en not_active Expired - Fee Related
• 2002
  • 2002-03-14 EP EP02728455A patent/EP1373928A1/en not_active Withdrawn
  • 2002-03-14 JP JP2002573911A patent/JP4418630B2/ja not_active Expired - Fee Related
  • 2002-03-14 WO PCT/US2002/007615 patent/WO2002075357A1/en not_active Ceased

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