WO2002074288A3 - Composés chimiques - Google Patents

Composés chimiques Download PDF

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Publication number
WO2002074288A3
WO2002074288A3 PCT/GB2002/001220 GB0201220W WO02074288A3 WO 2002074288 A3 WO2002074288 A3 WO 2002074288A3 GB 0201220 W GB0201220 W GB 0201220W WO 02074288 A3 WO02074288 A3 WO 02074288A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
sexual dysfunction
tetrahydrobenz
ssri
carboxamide
Prior art date
Application number
PCT/GB2002/001220
Other languages
English (en)
Other versions
WO2002074288A2 (fr
Inventor
John Blundell Hutchison
Original Assignee
Vernalis Res Ltd
John Blundell Hutchison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Res Ltd, John Blundell Hutchison filed Critical Vernalis Res Ltd
Priority to AU2002246228A priority Critical patent/AU2002246228A1/en
Publication of WO2002074288A2 publication Critical patent/WO2002074288A2/fr
Publication of WO2002074288A3 publication Critical patent/WO2002074288A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

La présente invention concerne l'utilisation d'une quantité suffisante du composé (I) dans la fabrication d'un médicament destiné au traitement d'une dysfonction sexuelle chez un patient en train ou sur le point de subir un traitement avec un inhibiteur sélectif de recaptage de la sérotonine. L'invention concerne également l'utilisation d'une quantité suffisante du composé (I) et de l'un au moins des inhibiteurs de recaptage de la sérotonine pour la fabrication d'un médicament destiné au traitement de la dépression sans induire de dysfonction sexuelle.
PCT/GB2002/001220 2001-03-15 2002-03-15 Composés chimiques WO2002074288A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002246228A AU2002246228A1 (en) 2001-03-15 2002-03-15 Treatment and prevention of sexual dysfunction resulting from ssri-therapy by using a tetrahydrobenz cd indole-6-carboxamide

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0106446.8 2001-03-15
GBGB0106446.8A GB0106446D0 (en) 2001-03-15 2001-03-15 Chemical compounds

Publications (2)

Publication Number Publication Date
WO2002074288A2 WO2002074288A2 (fr) 2002-09-26
WO2002074288A3 true WO2002074288A3 (fr) 2003-02-27

Family

ID=9910774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001220 WO2002074288A2 (fr) 2001-03-15 2002-03-15 Composés chimiques

Country Status (3)

Country Link
AU (1) AU2002246228A1 (fr)
GB (1) GB0106446D0 (fr)
WO (1) WO2002074288A2 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
JP2007516949A (ja) * 2003-07-16 2007-06-28 ファイザー・インク 性機能不全の治療
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
ES2646326T3 (es) 2005-08-03 2017-12-13 Sprout Pharmaceuticals, Inc. Uso de flibanserina en el tratamiento de la obesidad
DE602007004615D1 (de) 2006-06-30 2010-03-18 Boehringer Ingelheim Pharma Flibanserin zur behandlung von harninkontinenz und assoziierten erkrankungen
CL2008002693A1 (es) 2007-09-12 2009-10-16 Boehringer Ingelheim Int Uso de flibanserina para el tratamiento de sintomas vasomotores seleccionados de sofocos, sudores nocturnos, cambios de estado de animo e irritabilidad
CA2686480A1 (fr) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh Nouveaux sels

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633023A2 (fr) * 1993-06-10 1995-01-11 Eli Lilly And Company Prévention de l'émésis et traitement de la dysfunctionnement sexuelle par des tétrahydro(CD)indole-6-carboxamides

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0633023A2 (fr) * 1993-06-10 1995-01-11 Eli Lilly And Company Prévention de l'émésis et traitement de la dysfunctionnement sexuelle par des tétrahydro(CD)indole-6-carboxamides
US5703112A (en) * 1993-06-10 1997-12-30 Eli Lilly And Company Method of preventing emesis using tetrahydrobenz CD!indole-6-carbonxamides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BEERS M H AND BERKOW R: "The Merck Manual", 1999, MERCK RESEARCH LABORATORIES, WHITEHOUSE STATION, N.J., XP002215956 *

Also Published As

Publication number Publication date
WO2002074288A2 (fr) 2002-09-26
AU2002246228A1 (en) 2002-10-03
GB0106446D0 (en) 2001-05-02

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