WO2002072760A3 - Pcra helicase inhibitors - Google Patents

Pcra helicase inhibitors Download PDF

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Publication number
WO2002072760A3
WO2002072760A3 PCT/US2002/006941 US0206941W WO02072760A3 WO 2002072760 A3 WO2002072760 A3 WO 2002072760A3 US 0206941 W US0206941 W US 0206941W WO 02072760 A3 WO02072760 A3 WO 02072760A3
Authority
WO
WIPO (PCT)
Prior art keywords
helicase inhibitors
pcra helicase
pcra
inhibitors
broad
Prior art date
Application number
PCT/US2002/006941
Other languages
French (fr)
Other versions
WO2002072760A2 (en
Inventor
Dirk A Heerding
Catherine C K Yuan
Original Assignee
Smithkline Beecham Corp
Dirk A Heerding
Catherine C K Yuan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Dirk A Heerding, Catherine C K Yuan filed Critical Smithkline Beecham Corp
Priority to AU2002254136A priority Critical patent/AU2002254136A1/en
Publication of WO2002072760A2 publication Critical patent/WO2002072760A2/en
Publication of WO2002072760A3 publication Critical patent/WO2002072760A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to the novel PcrA helicase inhibitors useful as broad-spectrum antibacterials.
PCT/US2002/006941 2001-03-08 2002-03-07 Pcra helicase inhibitors WO2002072760A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002254136A AU2002254136A1 (en) 2001-03-08 2002-03-07 Pcra helicase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27444801P 2001-03-08 2001-03-08
US60/274,448 2001-03-08

Publications (2)

Publication Number Publication Date
WO2002072760A2 WO2002072760A2 (en) 2002-09-19
WO2002072760A3 true WO2002072760A3 (en) 2004-02-12

Family

ID=23048237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006941 WO2002072760A2 (en) 2001-03-08 2002-03-07 Pcra helicase inhibitors

Country Status (2)

Country Link
AU (1) AU2002254136A1 (en)
WO (1) WO2002072760A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY143244A (en) 2002-11-26 2011-04-15 Smithkline Beecham Corp Calcilytic compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] FEMMER ET AL.: "Pharmacology of 1-phenylaminoethylamino-3-(phenoxy)proponal derivatives with beta-adrenergic effect", XP002956851, accession no. STN Database accession no. 1983:569058 *
DATABASE CAPLUS [online] RZESZOTARSKI ET AL.: "Cardioselectivity of beta-adrenoceptor blocking agents 2. Role of the amino group substituent", XP002907410, accession no. STN Database accession no. 1983:400148 *
J. MED. CHEM., vol. 26, no. 5, 1983, pages 644 - 648 *
PHARMAZIE, vol. 38, no. 6, 1983, pages 409 - 414 *

Also Published As

Publication number Publication date
AU2002254136A1 (en) 2002-09-24
WO2002072760A2 (en) 2002-09-19

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