WO2002072753A3 - Peptides de thymidylate synthase se fixant a l'arnm de la thymidylate synthase - Google Patents

Peptides de thymidylate synthase se fixant a l'arnm de la thymidylate synthase Download PDF

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Publication number
WO2002072753A3
WO2002072753A3 PCT/US2002/006634 US0206634W WO02072753A3 WO 2002072753 A3 WO2002072753 A3 WO 2002072753A3 US 0206634 W US0206634 W US 0206634W WO 02072753 A3 WO02072753 A3 WO 02072753A3
Authority
WO
WIPO (PCT)
Prior art keywords
thymidylate synthase
mrna
bind
amino acids
peptide
Prior art date
Application number
PCT/US2002/006634
Other languages
English (en)
Other versions
WO2002072753A2 (fr
Inventor
Carmen J Allegra
Donna M Voeller
Original Assignee
Us Gov Health & Human Serv
Carmen J Allegra
Donna M Voeller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Us Gov Health & Human Serv, Carmen J Allegra, Donna M Voeller filed Critical Us Gov Health & Human Serv
Priority to AU2002250220A priority Critical patent/AU2002250220A1/en
Publication of WO2002072753A2 publication Critical patent/WO2002072753A2/fr
Publication of WO2002072753A3 publication Critical patent/WO2002072753A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1007—Methyltransferases (general) (2.1.1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/164—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

L'invention porte sur un procédé d'inhibition de la traduction de l'ARNm codant pour la thymidylate synthase (TS), consistant à mettre en contact l'ARN m ou une cellule l'exprimant avec un peptide consistant essentiellement en environ 10 à 25 acides aminés de la région interface du peptide de la TS, ledit peptide se fixant audit ARNm et en inhibant la traduction. L'invention porte également sur des procédés d'identification d'agents se fixant à l'ARNm de la TS et en inhibant la traduction, et sur une méthode de traitement d'un sujet à l'aide d'un peptide consistant essentiellement en environ 10 à 25 acides aminés de la région interface du peptide de la TS.
PCT/US2002/006634 2001-03-07 2002-03-05 Peptides de thymidylate synthase se fixant a l'arnm de la thymidylate synthase WO2002072753A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250220A AU2002250220A1 (en) 2001-03-07 2002-03-05 Thymidylate synthase peptides that bind to thymidylate synthase messenger rna

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27410701P 2001-03-07 2001-03-07
US60/274,107 2001-03-07

Publications (2)

Publication Number Publication Date
WO2002072753A2 WO2002072753A2 (fr) 2002-09-19
WO2002072753A3 true WO2002072753A3 (fr) 2005-03-31

Family

ID=23046797

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/006634 WO2002072753A2 (fr) 2001-03-07 2002-03-05 Peptides de thymidylate synthase se fixant a l'arnm de la thymidylate synthase

Country Status (2)

Country Link
AU (1) AU2002250220A1 (fr)
WO (1) WO2002072753A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20092117A1 (it) * 2009-12-01 2011-06-02 Univ Degli Studi Modena E Reggio Emilia Struttura del cristallo del complesso di timidilato sintetasi (ts) con un ligando
US8916679B2 (en) * 2009-12-01 2014-12-23 Universita′ degli Studi di Modena e Reggio Emilia Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHU, E. ET AL.: "Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase", PROC. NATL. ACAD SCI. USA, vol. 8, October 1991 (1991-10-01), pages 8977 - 8981, XP002081371 *
CHU, E. ET AL.: "Identification of an RNA binding site for human thymidylate synthase", PROC. NATL. ACAD. SCI. USA, vol. 90, January 1993 (1993-01-01), pages 517 - 521, XP002081370 *
LIN, X. ET AL.: "Characterization of a cis-acting regulatory element in the protein coding region of thymidylate synthase mRNA", NUCLEIC ACIDS RESEARCH, vol. 28, no. 6, 15 March 2000 (2000-03-15), pages 1381 - 1389, XP002984376 *
VOELLER, D.M. ET AL.: "The identification of thymidylate synthase peptide domains located in the interface region that bind thymidylate synthase mRNA", BIOCHEM. BIOPHYS. RES. COMUN., vol. 297, July 2002 (2002-07-01), pages 24 - 31, XP002984377 *

Also Published As

Publication number Publication date
AU2002250220A1 (en) 2002-09-24
WO2002072753A2 (fr) 2002-09-19

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