WO2002069790A3 - Verfahren zur bestimmung eines lichttransportparameters in einer biologischen matrix - Google Patents

Verfahren zur bestimmung eines lichttransportparameters in einer biologischen matrix Download PDF

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Publication number
WO2002069790A3
WO2002069790A3 PCT/EP2002/001944 EP0201944W WO02069790A3 WO 2002069790 A3 WO2002069790 A3 WO 2002069790A3 EP 0201944 W EP0201944 W EP 0201944W WO 02069790 A3 WO02069790 A3 WO 02069790A3
Authority
WO
WIPO (PCT)
Prior art keywords
light
biological matrix
determination
transport parameter
light transport
Prior art date
Application number
PCT/EP2002/001944
Other languages
English (en)
French (fr)
Other versions
WO2002069790A2 (de
Inventor
Uwe Kraemer
Heinz-Michael Hein
Dietmar Volz
Original Assignee
Roche Diagnostics Gmbh
Hoffmann La Roche
Uwe Kraemer
Heinz-Michael Hein
Dietmar Volz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics Gmbh, Hoffmann La Roche, Uwe Kraemer, Heinz-Michael Hein, Dietmar Volz filed Critical Roche Diagnostics Gmbh
Priority to AU2002251002A priority Critical patent/AU2002251002A1/en
Priority to EP02719907A priority patent/EP1365681A2/de
Priority to US10/471,113 priority patent/US7565249B2/en
Publication of WO2002069790A2 publication Critical patent/WO2002069790A2/de
Publication of WO2002069790A3 publication Critical patent/WO2002069790A3/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
    • A61B2562/02—Details of sensors specially adapted for in-vivo measurements
    • A61B2562/0233—Special features of optical sensors or probes classified in A61B5/00
    • A61B2562/0242—Special features of optical sensors or probes classified in A61B5/00 for varying or adjusting the optical path length in the tissue
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y10T436/144444—Glucose

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Emergency Medicine (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

Verfahren zur selektiven Bestimmung eines für die Lichtstreuung in einer biologischen Matrix (5) charakteristischen Lichttransportparameters, insbesondere zum Zwecke der nichtinvasiven Bestimmung der Konzentration von Glucose in der biologischen Matrix. Es schließt eine Mehrzahl von Detektionsmessungen ein, bei denen jeweils Licht als Primärlicht in die biologische Matrix eingestrahlt und ein Intensitätsmeßwert von an einem Detektionsort der sich bei der Mehrzahl von Detektionmessungen in unterschiedlichen Meßabständen von dem Einstrahlungsort befindet, austretendem Sekundärlicht gemessen wird. In einem Auswerteschritt wird der für die Lichtstreuung in der biologischen Matrix charakteristische Lichttransportparameter mittels eines Auswertealgorithmus aus den Intensitätsmeßwerten abgeleitet. Zur selektiven Bestimmung des Streukoeffizienten wird vorgeschlagen, daß der Auswertealgorithmus einen Schritt einschließt, bei dem aus mindestes zwei zu unterschiedlichen Zeitpunkten gewonnenen Intensitätsmeßwerten ein die zeitliche Änderung des Intensitätsmeßwertes beschreibender Zeitableitungswert ΔtI(r) berechnet wird.
PCT/EP2002/001944 2001-03-06 2002-02-23 Verfahren zur bestimmung eines lichttransportparameters in einer biologischen matrix WO2002069790A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002251002A AU2002251002A1 (en) 2001-03-06 2002-02-23 Method for the determination of a light transport parameter in a biological matrix
EP02719907A EP1365681A2 (de) 2001-03-06 2002-02-23 Verfahren zur bestimmung eines lichttransportparameters in einer biologischen matrix
US10/471,113 US7565249B2 (en) 2001-03-06 2002-02-23 Method for the determination of a light transport parameter in a biological matrix

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10110599A DE10110599A1 (de) 2001-03-06 2001-03-06 Verfahren zur Bestimmung eines Lichttransportparameters in einer biologischen Matrix
DE10110599.1 2001-03-06

Publications (2)

Publication Number Publication Date
WO2002069790A2 WO2002069790A2 (de) 2002-09-12
WO2002069790A3 true WO2002069790A3 (de) 2002-12-27

Family

ID=7676392

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001944 WO2002069790A2 (de) 2001-03-06 2002-02-23 Verfahren zur bestimmung eines lichttransportparameters in einer biologischen matrix

Country Status (5)

Country Link
US (1) US7565249B2 (de)
EP (1) EP1365681A2 (de)
AU (1) AU2002251002A1 (de)
DE (1) DE10110599A1 (de)
WO (1) WO2002069790A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10163972B4 (de) 2001-12-22 2005-10-27 Roche Diagnostics Gmbh Verfahren und Vorrichtung zur Bestimmung eines Lichttransportparameters und eines Analyten in einer biologischen Matrix
JP2013103094A (ja) * 2011-11-16 2013-05-30 Sony Corp 測定装置、測定方法、プログラム及び記録媒体
US10485461B2 (en) 2016-07-29 2019-11-26 Samsung Electronics Co., Ltd. Apparatus and method for estimating substance in blood
WO2023210521A1 (ja) * 2022-04-27 2023-11-02 国立研究開発法人産業技術総合研究所 光学特性値計測装置及び光学特性値計測方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0710832A1 (de) * 1994-11-07 1996-05-08 Hamamatsu Photonics K.K. Verfahren und Vorrichtung zur Messung der Streu- und Absorptionseigenschaften eines streuenden Mediums
US5867807A (en) * 1995-10-26 1999-02-02 Agency Of Industrial Science & Technology, Ministry Of International Trade & Industry Method and apparatus for determination of optical properties of light scattering material
EP0760091B1 (de) * 1994-05-19 1999-11-03 Roche Diagnostics GmbH Verfahren und vorrichtung zur bestimmung eines analyten in einer biologischen probe

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US551422A (en) * 1895-12-17 Churn
US5782755A (en) * 1993-11-15 1998-07-21 Non-Invasive Technology, Inc. Monitoring one or more solutes in a biological system using optical techniques
IL107396A (en) 1992-11-09 1997-02-18 Boehringer Mannheim Gmbh Method and apparatus for analytical determination of glucose in a biological matrix
DE4337570A1 (de) * 1993-11-04 1995-05-11 Boehringer Mannheim Gmbh Verfahren zur Analyse von Glucose in einer biologischen Matrix
DE4417639A1 (de) 1994-05-19 1995-11-23 Boehringer Mannheim Gmbh Verfahren zur Bestimmung eines Analyten in einer biologischen Probe
DE19543020A1 (de) 1995-11-18 1997-05-22 Boehringer Mannheim Gmbh Verfahren und Vorrichtung zur Bestimmung von analytischen Daten über das Innere einer streuenden Matrix
US6615061B1 (en) * 1998-11-23 2003-09-02 Abbott Laboratories Optical sensor having a selectable sampling distance for determination of analytes

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0760091B1 (de) * 1994-05-19 1999-11-03 Roche Diagnostics GmbH Verfahren und vorrichtung zur bestimmung eines analyten in einer biologischen probe
EP0710832A1 (de) * 1994-11-07 1996-05-08 Hamamatsu Photonics K.K. Verfahren und Vorrichtung zur Messung der Streu- und Absorptionseigenschaften eines streuenden Mediums
US5867807A (en) * 1995-10-26 1999-02-02 Agency Of Industrial Science & Technology, Ministry Of International Trade & Industry Method and apparatus for determination of optical properties of light scattering material

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TUALLE J-M ET AL: "Real time optical coefficients evaluation from time and space resolved reflectance measurements in biological tissues", OPTICS COMMUNICATIONS, NORTH-HOLLAND PUBLISHING CO. AMSTERDAM, NL, vol. 124, no. 3, 1 March 1996 (1996-03-01), pages 216 - 221, XP004021673, ISSN: 0030-4018 *

Also Published As

Publication number Publication date
DE10110599A1 (de) 2002-09-12
WO2002069790A2 (de) 2002-09-12
US7565249B2 (en) 2009-07-21
EP1365681A2 (de) 2003-12-03
AU2002251002A1 (en) 2002-09-19
US20040152089A1 (en) 2004-08-05

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