WO2002068457A3 - Antiangiogenic peptides derived from endostatin - Google Patents

Antiangiogenic peptides derived from endostatin Download PDF

Info

Publication number
WO2002068457A3
WO2002068457A3 PCT/IT2002/000119 IT0200119W WO02068457A3 WO 2002068457 A3 WO2002068457 A3 WO 2002068457A3 IT 0200119 W IT0200119 W IT 0200119W WO 02068457 A3 WO02068457 A3 WO 02068457A3
Authority
WO
WIPO (PCT)
Prior art keywords
endostatin
peptides derived
antiangiogenic peptides
antiangiogenic
peptides
Prior art date
Application number
PCT/IT2002/000119
Other languages
French (fr)
Other versions
WO2002068457A2 (en
Inventor
Francesco Chillemi
Lucia Maria Teresa Vicentinie
Pierangelo Francescato
Original Assignee
Univ Degli Studi Milano
Francesco Chillemi
Lucia Maria Teresa Vicentinie
Pierangelo Francescato
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Milano, Francesco Chillemi, Lucia Maria Teresa Vicentinie, Pierangelo Francescato filed Critical Univ Degli Studi Milano
Priority to EP20020707102 priority Critical patent/EP1370587A2/en
Priority to US10/468,759 priority patent/US20040073007A1/en
Priority to JP2002567967A priority patent/JP2004534736A/en
Priority to AU2002241253A priority patent/AU2002241253A1/en
Publication of WO2002068457A2 publication Critical patent/WO2002068457A2/en
Publication of WO2002068457A3 publication Critical patent/WO2002068457A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides with antiangiogenic activity with a sequence corresponding to that of fragments of human endostatin.
PCT/IT2002/000119 2001-02-27 2002-02-27 Antiangiogenic peptides derived from endostatin WO2002068457A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP20020707102 EP1370587A2 (en) 2001-02-27 2002-02-27 Antiangiogenic peptides derived from endostatin
US10/468,759 US20040073007A1 (en) 2001-02-27 2002-02-27 Antiangiogenic peptides
JP2002567967A JP2004534736A (en) 2001-02-27 2002-02-27 Anti-angiogenic peptide
AU2002241253A AU2002241253A1 (en) 2001-02-27 2002-02-27 Antiangiogenic peptides derived from endostatin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2001A000394 2001-02-27
IT2001MI000394A ITMI20010394A1 (en) 2001-02-27 2001-02-27 PEPTIDES WITH ANTIANGIOGENIC ACTIVITY

Publications (2)

Publication Number Publication Date
WO2002068457A2 WO2002068457A2 (en) 2002-09-06
WO2002068457A3 true WO2002068457A3 (en) 2002-11-14

Family

ID=11447030

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2002/000119 WO2002068457A2 (en) 2001-02-27 2002-02-27 Antiangiogenic peptides derived from endostatin

Country Status (6)

Country Link
US (1) US20040073007A1 (en)
EP (1) EP1370587A2 (en)
JP (1) JP2004534736A (en)
AU (1) AU2002241253A1 (en)
IT (1) ITMI20010394A1 (en)
WO (1) WO2002068457A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524811B2 (en) * 2003-08-29 2009-04-28 Children's Medical Center Corporation Anti-angiogenic peptides from the N-terminus of endostatin
KR20070030159A (en) * 2003-08-29 2007-03-15 칠드런'즈 메디컬 센터 코포레이션 Anti-angiogenic peptides from the n-terminus of endostatin
ITMI20040364A1 (en) * 2004-02-27 2004-05-27 Francesco Chillemi PEPTIDES WITH ANTIANGIOGENIC AND ANTI-TUMOR ACTIVITY
EP1640382A1 (en) * 2004-08-16 2006-03-29 Université de Liège Anti-angiogenic peptides
US8507441B2 (en) 2009-10-22 2013-08-13 University of Pittsburgh—Of the Commonwealth Systems of Higher Education Use of endostatin peptides for the treatment of fibrosis

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015666A1 (en) * 1995-10-23 1997-05-01 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
DE19615710A1 (en) * 1996-04-22 1997-10-23 Forssmann Wolf Georg Process for obtaining and using a biologically active protein - collagen fragment HF-COLL-18 / 514cf - in partially purified and synthetic form from body fluids to influence cell growth and the diagnosis of collagen diseases and osteoporosis
WO1999048924A1 (en) * 1998-03-24 1999-09-30 The Children's Medical Center Corporation Endostatin derived peptides with anti-angiogenic and anti-cancer activity
WO2000063249A1 (en) * 1999-04-15 2000-10-26 Universita' Degli Studi Di Milano Polypeptides derived from endostatin exhibiting antiangiogenic activity
WO2000067771A1 (en) * 1999-05-06 2000-11-16 The Burnham Institute Antiangiogenic endostatin peptides, endostatin variants and methods of use

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997015666A1 (en) * 1995-10-23 1997-05-01 The Children's Medical Center Corporation Therapeutic antiangiogenic compositions and methods
DE19615710A1 (en) * 1996-04-22 1997-10-23 Forssmann Wolf Georg Process for obtaining and using a biologically active protein - collagen fragment HF-COLL-18 / 514cf - in partially purified and synthetic form from body fluids to influence cell growth and the diagnosis of collagen diseases and osteoporosis
WO1999048924A1 (en) * 1998-03-24 1999-09-30 The Children's Medical Center Corporation Endostatin derived peptides with anti-angiogenic and anti-cancer activity
WO2000063249A1 (en) * 1999-04-15 2000-10-26 Universita' Degli Studi Di Milano Polypeptides derived from endostatin exhibiting antiangiogenic activity
WO2000067771A1 (en) * 1999-05-06 2000-11-16 The Burnham Institute Antiangiogenic endostatin peptides, endostatin variants and methods of use

Also Published As

Publication number Publication date
US20040073007A1 (en) 2004-04-15
AU2002241253A1 (en) 2002-09-12
EP1370587A2 (en) 2003-12-17
WO2002068457A2 (en) 2002-09-06
ITMI20010394A1 (en) 2002-08-27
JP2004534736A (en) 2004-11-18

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