WO2002067858A3 - Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms - Google Patents

Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms Download PDF

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Publication number
WO2002067858A3
WO2002067858A3 PCT/US2002/005151 US0205151W WO02067858A3 WO 2002067858 A3 WO2002067858 A3 WO 2002067858A3 US 0205151 W US0205151 W US 0205151W WO 02067858 A3 WO02067858 A3 WO 02067858A3
Authority
WO
WIPO (PCT)
Prior art keywords
isoforms
trkc
trkb
neurodegenerative diseases
novel treatment
Prior art date
Application number
PCT/US2002/005151
Other languages
French (fr)
Other versions
WO2002067858A2 (en
Inventor
Bruce K Krueger
Tami J Kingsbury
Linda L Bambrick
Susan G Dorsey
Original Assignee
Univ Maryland
Bruce K Krueger
Tami J Kingsbury
Linda L Bambrick
Susan G Dorsey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland, Bruce K Krueger, Tami J Kingsbury, Linda L Bambrick, Susan G Dorsey filed Critical Univ Maryland
Priority to AU2002306556A priority Critical patent/AU2002306556A1/en
Priority to PCT/US2002/016807 priority patent/WO2003071872A1/en
Priority to AU2002257333A priority patent/AU2002257333A1/en
Publication of WO2002067858A2 publication Critical patent/WO2002067858A2/en
Publication of WO2002067858A3 publication Critical patent/WO2002067858A3/en
Priority to US10/645,546 priority patent/US7060429B2/en
Priority to US11/326,389 priority patent/US20060148749A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70571—Receptors; Cell surface antigens; Cell surface determinants for neuromediators, e.g. serotonin receptor, dopamine receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

This invention relates to a method of treating or preventing neuro-degenerative disorders and neuro-developmental disorders by altering the ratio of the amount of full-length TrkB polypeptide to the amount of truncated TrkB polypeptides in a neuron or by altering the ratio of the amount of full-length TrkC polypeptide to the amount of truncated TrkC polypeptides in a neuron.
PCT/US2002/005151 2001-02-22 2002-02-22 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms WO2002067858A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2002306556A AU2002306556A1 (en) 2001-02-22 2002-02-22 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
PCT/US2002/016807 WO2003071872A1 (en) 2002-02-22 2002-05-28 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
AU2002257333A AU2002257333A1 (en) 2002-02-22 2002-05-28 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms
US10/645,546 US7060429B2 (en) 2001-02-22 2003-08-22 Treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms
US11/326,389 US20060148749A1 (en) 2002-02-22 2006-01-06 Novel treatment of neurodegenerative diseases by altering levels of TrkB isoforms and/or TrkC isoforms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27055301P 2001-02-22 2001-02-22
US60/270,553 2001-02-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/016807 Continuation WO2003071872A1 (en) 2001-02-22 2002-05-28 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms

Publications (2)

Publication Number Publication Date
WO2002067858A2 WO2002067858A2 (en) 2002-09-06
WO2002067858A3 true WO2002067858A3 (en) 2003-02-27

Family

ID=23031768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/005151 WO2002067858A2 (en) 2001-02-22 2002-02-22 Novel treatment of neurodegenerative diseases by altering levels of trkb isoforms and/or trkc isoforms

Country Status (2)

Country Link
AU (1) AU2002306556A1 (en)
WO (1) WO2002067858A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1551424B1 (en) 2002-09-04 2015-07-01 Arrowhead Research Corporation Treatment of chronic neuropathic pain by admistration of dsrna
CA2690685A1 (en) * 2007-06-20 2008-12-24 Galapagos N.V. Molecular targets and compounds, and methods to identify the same, useful in the treatment of bone and joint degenerative diseases
ES2479815B1 (en) * 2012-12-24 2015-05-06 Consejo Superior De Investigaciones Cientificas (Csic) NEUROPROTECTOR PEPTIDE ASI AS ITS USE IN THE TREATMENT OF CEREBROVASCULAR DISEASES AND OTHER CNS PATHOLOGIES

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HITOSHI S. ET AL: "Rabbit experimental sensory ataxic neuropathy: Anti-GD1b antibody-mediated trkC downregulation of dorsal root ganglia neurons", NEUROSCIENCE LETTERS, vol. 260, no. 3, 5 February 1999 (1999-02-05), pages 157 - 160, XP002960628 *
KOHJI T. ET AL: "Cerebellar neurodegeneration in human hereditary DNA repair disorders", NEUROSCIENCE LETTERS, vol. 243, no. 1,2,3, 1998, pages 133 - 136, XP002960632 *
LOWRY K.S. ET AL: "A comparison between antisense p75NTR oligonucleotides and neurotrophic factors in promoting the survival of postnatal sensory neurons in vitro", VITRO CELLULAR & DEVELOPMENTAL BIOLOGY: ANIMAL, vol. 36, no. 8, 2000, pages 520 - 526, XP002960631 *
OYESIKU N.M. ET AL: "Regional changes in the expression of neurotrophic factors and their receptors following acute traumatic brain injury in the adult rat brain", BRAIN RESEARCH, vol. 833, no. 2, 3 July 1999 (1999-07-03), pages 161 - 172, XP002960630 *
RICKMAN D.W. ET AL: "Suppression of trkB expression by antisense oligonucleotides alters a neuronal phenotype in the rod pathway of the developing rat retina", PROC. NATL. ACAD. SCI. USA, vol. 93, October 1996 (1996-10-01), pages 12564 - 12569, XP002960627 *
WUELLNER U. ET AL: "Expression of neurotruphins and neurotrophin receptors in the cerebellum of mutant weaver and lurcher mice", DEVELOPMENTAL RESEARCH, vol. 110, no. 1, 10 September 1998 (1998-09-10), pages 1 - 6, XP002960629 *

Also Published As

Publication number Publication date
AU2002306556A1 (en) 2002-09-12
WO2002067858A2 (en) 2002-09-06

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