WO2002062721A1 - Premixed calcium phosphate cement pastes - Google Patents
Premixed calcium phosphate cement pastes Download PDFInfo
- Publication number
- WO2002062721A1 WO2002062721A1 PCT/US2002/001991 US0201991W WO02062721A1 WO 2002062721 A1 WO2002062721 A1 WO 2002062721A1 US 0201991 W US0201991 W US 0201991W WO 02062721 A1 WO02062721 A1 WO 02062721A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- paste
- glycerol
- composition
- phosphate
- liquid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/54—Filling; Sealing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/838—Phosphorus compounds, e.g. apatite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/864—Phosphate cements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/849—Preparations for artificial teeth, for filling teeth or for capping teeth comprising inorganic cements
- A61K6/873—Carbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
- A61K6/898—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B28/00—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements
- C04B28/34—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders
- C04B28/344—Compositions of mortars, concrete or artificial stone, containing inorganic binders or the reaction product of an inorganic and an organic binder, e.g. polycarboxylate cements containing cold phosphate binders the phosphate binder being present in the starting composition solely as one or more phosphates
-
- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
- C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
- C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
Definitions
- a self-hardening calcium phosphate cement consisting of tetra calcium phosphate (TTCP) and anhydrous dicalcium phosphate has been shown in clinical studies to be efficacious as a bone repair material.
- the hardening time (HT) of the cement is about 30 min when the powder constituents are mixed with water and 5 min when mixed with a phosphate solution as the liquid.
- Hydroxyapatite (HA) is the major product formed as a result of the mixing and hardening.
- CPC calcium phosphate cements
- a cement paste of the type referenced mixed with glycerol was studied for root canal filling, sealing, and injectability and it was reported that the glycerol-calcium phosphate cement (CPC) paste showed better biocompatibility than a number of presently used root canal filling or sealing materials.
- CPC glycerol-calcium phosphate cement
- the present invention comprises compositions and means for formulating premixed glycerol and calcium phosphate cement pastes that are stable in a package, resist washout, and will harden only after being delivered to the defect or implant site.
- Glycerol was used as the liquid because the CPC hardening reaction to form HA does not occur in a water-free environment.
- Hydroxypropyl methylcellulose (HMC) and Na 2 HPO 4 were also added to improve the paste cohesiveness and accelerate cement hardening upon delivery to a desired repair site.
- DESCRIPTION OF THE PREFERRED EMBODIMENT TTCP was prepared by heating an equimolar mixture of commercially obtained DCPA and CaCO 3 at 1500°C for six hours in a furnace and then quenched in air or inert gas to room temperature. Also, TCP was prepared by heating a mixture that contained 2 mol of DCPA and 1 mol of CaCO to 1200°C for six hours followed by quenching to room temperature. The powders used were ground individually in a planetary ball mill in cyclohexane, ethanol, or dry to obtain the desired median particle size which is about 15 microns and as disclosed in the prior art for making CPC powders.
- Diametral tensile strength (DTS) samples were prepared by placing the paste into molds (6 mm diameter x 3 mm height) with ⁇ 2 MP a of pressure applied.
- PLS physiologic-like solution
- a Universal Testing Machine (United Calibration Corp, Garden Grove, CA, USA) measured DTD values at a loading rate of 10 mm/min.
- the Gilmore needle method measured HT.
- Powder X-ray diffraction analysis (XRD) determined the extent of CPC conversion to HA.
- the premixed CPC pastes would generally have a longer hardening time and lower physical strength, but the results suggest that cement pastes with excellent washout resistance can be prepared by incorporating HMC and Na 2 HPO 4 in glycerol.
- Phosphate generally decreased HT and DTS for CPC-1, and increased DTS for CPC-II and -III.
- HMC appeared to decrease HA formation for CPC-I, but had no effect for CPC-II and -III, and did not affect DTS.
- a bone replacement or dental replacement paste results by combining dry powder constituents, characterized by their conversion to HA in the presence of water or phosphate solutions, with glycerol and hydroxypropyl methyl cellulose and/or Na HPO 4 .
- the ratio of combined constituents is broad and the resulting paste can be formulated to control rather precisely, the hardening times.
- Glycerol compounds, analogs and substitutes as well as cellulose analogs and substitutes are within the scope of the invention.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Ceramic Engineering (AREA)
- Structural Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials Engineering (AREA)
- Organic Chemistry (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Materials For Medical Uses (AREA)
- Dental Preparations (AREA)
Abstract
Description
Claims
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2002251814A AU2002251814A1 (en) | 2001-01-24 | 2002-01-24 | Premixed calcium phosphate cement pastes |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26389401P | 2001-01-24 | 2001-01-24 | |
US60/263,894 | 2001-01-24 | ||
US10/057,554 US6793725B2 (en) | 2001-01-24 | 2002-01-23 | Premixed calcium phosphate cement pastes |
US10/057,554 | 2002-01-23 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2002062721A1 true WO2002062721A1 (en) | 2002-08-15 |
WO2002062721B1 WO2002062721B1 (en) | 2003-03-06 |
WO2002062721A8 WO2002062721A8 (en) | 2003-04-24 |
Family
ID=26736618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2002/001991 WO2002062721A1 (en) | 2001-01-24 | 2002-01-24 | Premixed calcium phosphate cement pastes |
Country Status (3)
Country | Link |
---|---|
US (1) | US6793725B2 (en) |
AU (1) | AU2002251814A1 (en) |
WO (1) | WO2002062721A1 (en) |
Cited By (6)
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EP1742648A2 (en) * | 2004-04-15 | 2007-01-17 | Etex Corporation | Delayed-setting calcium phosphate pastes |
EP1746974A2 (en) * | 2004-05-20 | 2007-01-31 | Skeletal Kinetics LLC | Rapid setting calcium phosphate cements |
WO2008128347A1 (en) * | 2007-04-20 | 2008-10-30 | Innovative Bioceramix, Inc. | Premixed biological hydraulic cement paste composition and using the same |
DE102008028738A1 (en) | 2007-06-06 | 2008-12-11 | Innotere Gmbh | Implant material based on a hydraulic cement and its use |
CN102049062A (en) * | 2009-10-30 | 2011-05-11 | 华东理工大学 | Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof |
EP4335466A1 (en) | 2022-09-08 | 2024-03-13 | Heraeus Medical GmbH | Composition for the preparation of a bone substitute material, method for the preparation of a pharmaceutical active substance carrier, pharmaceutical active substance carrier and its use |
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US6840995B2 (en) * | 1999-07-14 | 2005-01-11 | Calcitec, Inc. | Process for producing fast-setting, bioresorbable calcium phosphate cements |
US7270705B2 (en) * | 1999-07-14 | 2007-09-18 | Jiin-Huey Chern Lin | Method of increasing working time of tetracalcium phosphate cement paste |
US7094282B2 (en) * | 2000-07-13 | 2006-08-22 | Calcitec, Inc. | Calcium phosphate cement, use and preparation thereof |
US6960249B2 (en) * | 1999-07-14 | 2005-11-01 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface |
US7169373B2 (en) * | 1999-07-14 | 2007-01-30 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) having calcium phosphate whisker on surface and process for preparing the same |
US7156915B2 (en) * | 2000-07-13 | 2007-01-02 | Calcitec, Inc. | Tetracalcium phosphate (TTCP) with surface whiskers and method of making same |
US7204876B2 (en) * | 2000-07-13 | 2007-04-17 | Calcitec, Inc. | Calcium phosphate cements made from (TTCP) with surface whiskers and process for preparing same |
WO2004093734A2 (en) * | 2002-01-23 | 2004-11-04 | Ada Foundation | Premixed self-hardening bone graft pastes |
US7709029B2 (en) * | 2001-01-24 | 2010-05-04 | Ada Foundation | Calcium-containing restoration materials |
US20030216777A1 (en) * | 2002-05-16 | 2003-11-20 | Yin-Chun Tien | Method of enhancing healing of interfacial gap between bone and tendon or ligament |
FR2850282B1 (en) | 2003-01-27 | 2007-04-06 | Jerome Asius | INJECTABLE IMPLANT BASED ON CERAMIC FOR THE FILLING OF WRINKLES, CUTANEOUS DEPRESSIONS AND SCARS, AND ITS PREPARATION |
US20060076295A1 (en) | 2004-03-15 | 2006-04-13 | The Trustees Of Columbia University In The City Of New York | Systems and methods of blood-based therapies having a microfluidic membraneless exchange device |
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US7118705B2 (en) * | 2003-08-05 | 2006-10-10 | Calcitec, Inc. | Method for making a molded calcium phosphate article |
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US7163651B2 (en) * | 2004-02-19 | 2007-01-16 | Calcitec, Inc. | Method for making a porous calcium phosphate article |
US7309232B2 (en) | 2003-10-10 | 2007-12-18 | Dentigenix Inc. | Methods for treating dental conditions using tissue scaffolds |
US20050101964A1 (en) * | 2003-11-07 | 2005-05-12 | Calcitec, Inc. | Spinal fusion procedure using an injectable bone substitute |
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Cited By (14)
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JP2007533376A (en) * | 2004-04-15 | 2007-11-22 | エテックス コーポレーション | Delayed solidification calcium phosphate paste |
EP1742648A2 (en) * | 2004-04-15 | 2007-01-17 | Etex Corporation | Delayed-setting calcium phosphate pastes |
AU2005249365B2 (en) * | 2004-04-15 | 2011-04-07 | Etex Corporation | Delayed-setting calcium phosphate pastes |
EP1742648A4 (en) * | 2004-04-15 | 2009-03-04 | Etex Corp | Delayed-setting calcium phosphate pastes |
EP1746974A4 (en) * | 2004-05-20 | 2010-07-14 | Skeletal Kinetics Llc | Rapid setting calcium phosphate cements |
EP1746974A2 (en) * | 2004-05-20 | 2007-01-31 | Skeletal Kinetics LLC | Rapid setting calcium phosphate cements |
US8771748B2 (en) * | 2004-05-20 | 2014-07-08 | Skeletal Kinetics, Llc | Rapid setting calcium phosphate cements |
WO2008128347A1 (en) * | 2007-04-20 | 2008-10-30 | Innovative Bioceramix, Inc. | Premixed biological hydraulic cement paste composition and using the same |
US8475811B2 (en) | 2007-04-20 | 2013-07-02 | Innovative Bioceramix, Inc. | Premixed biological hydraulic cement paste composition and using the same |
WO2008148878A2 (en) | 2007-06-06 | 2008-12-11 | Innotere Gmbh | Hydraulic cement-based implant material and use thereof |
DE102008028738A1 (en) | 2007-06-06 | 2008-12-11 | Innotere Gmbh | Implant material based on a hydraulic cement and its use |
US9764057B2 (en) | 2007-06-06 | 2017-09-19 | Innotere Gmbh | Hydraulic cement-based implant material and use thereof |
CN102049062A (en) * | 2009-10-30 | 2011-05-11 | 华东理工大学 | Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof |
EP4335466A1 (en) | 2022-09-08 | 2024-03-13 | Heraeus Medical GmbH | Composition for the preparation of a bone substitute material, method for the preparation of a pharmaceutical active substance carrier, pharmaceutical active substance carrier and its use |
Also Published As
Publication number | Publication date |
---|---|
US6793725B2 (en) | 2004-09-21 |
US20020137812A1 (en) | 2002-09-26 |
WO2002062721B1 (en) | 2003-03-06 |
AU2002251814A1 (en) | 2002-08-19 |
WO2002062721A8 (en) | 2003-04-24 |
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