WO2002061074A1 - Novel protein and dna thereof - Google Patents

Novel protein and dna thereof Download PDF

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Publication number
WO2002061074A1
WO2002061074A1 PCT/JP2002/000636 JP0200636W WO02061074A1 WO 2002061074 A1 WO2002061074 A1 WO 2002061074A1 JP 0200636 W JP0200636 W JP 0200636W WO 02061074 A1 WO02061074 A1 WO 02061074A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
activity
inhibiting
screening
dna
Prior art date
Application number
PCT/JP2002/000636
Other languages
French (fr)
Japanese (ja)
Inventor
Atsushi Nakanishi
Yoji Sagiya
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2002061074A1 publication Critical patent/WO2002061074A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Abstract

It is intended to provide a novel protein having a neurotransmitter-operative channel activity, a DNA encoding this protein, a method of screening a compound promoting or inhibiting the activity of this protein, compounds obtained by the screening method, etc. More specifically, a protein having an amino acid sequence which is the same or substantially the same as the amino acid sequence represented by SEQ ID NO:1; a method/a kit for screening a compound promoting or inhibiting the activity of this protein; compounds promoting or inhibiting the activity of the above protein; and so on.
PCT/JP2002/000636 2001-01-30 2002-01-29 Novel protein and dna thereof WO2002061074A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001-22505 2001-01-30
JP2001022505 2001-01-30
JP2001-390239 2001-12-21
JP2001390239 2001-12-21

Publications (1)

Publication Number Publication Date
WO2002061074A1 true WO2002061074A1 (en) 2002-08-08

Family

ID=26608580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000636 WO2002061074A1 (en) 2001-01-30 2002-01-29 Novel protein and dna thereof

Country Status (1)

Country Link
WO (1) WO2002061074A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009633A1 (en) * 2002-07-19 2004-01-29 Inpharmatica Limited Serotonin receptor
WO2005073251A1 (en) * 2004-01-28 2005-08-11 Inpharmatica Limited Serotonin receptor

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
WO2001068849A2 (en) * 2000-03-10 2001-09-20 Pharmacia & Upjohn Company Human ion channels

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000073431A2 (en) * 1999-05-27 2000-12-07 Pharmacia & Upjohn Company Methods and compositions for measuring ion channel conductance
WO2001068849A2 (en) * 2000-03-10 2001-09-20 Pharmacia & Upjohn Company Human ion channels

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BOULTER, J. ET AL.: "Alpha3, alpha5 and beta4: three members of the rat neutral nicotinic acetylcholine receptor-related gene family form a gene cluster", J. BIOL. CHEM., vol. 265, no. 8, 1990, pages 4472 - 4482, XP002950795 *
DATABASE GENBANK [online] 18 April 1997 (1997-04-18), ADAMS, M.D. ET AL.: "EST16750 aorta endothelial cells, TNF alpha-treated homo sapiens cDNA 5' end, mRNA sequence", XP002950794, Database accession no. (AA304052) *
DATABASE GENBANK [online] 27 January 1997 (1997-01-27), HILLER, L. ET AL.: "Zq69b05. sl", Database accession no. (AA205715) *
DAVIES, P.A. ET AL.: "The 5-HT(3B) subunit is a major determinant of serotonin-receptor function", NATURE, vol. 397, no. 28, 1999, pages 359 - 363, XP002935591 *
HILLER, L. ET AL.: "A generation and analysis of 280,000 human expressed sequence tags", GENOME RES., vol. 6, no. 9, 1996, pages 807 - 828, XP002140684 *
MIYAKE, A. ET AL.: "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species", MOL. PHARMACOL., vol. 48, 1995, pages 407 - 416, XP001041842 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009633A1 (en) * 2002-07-19 2004-01-29 Inpharmatica Limited Serotonin receptor
WO2005073251A1 (en) * 2004-01-28 2005-08-11 Inpharmatica Limited Serotonin receptor

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