WO2002060930A3 - Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith - Google Patents

Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith Download PDF

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Publication number
WO2002060930A3
WO2002060930A3 PCT/EP2002/000997 EP0200997W WO02060930A3 WO 2002060930 A3 WO2002060930 A3 WO 2002060930A3 EP 0200997 W EP0200997 W EP 0200997W WO 02060930 A3 WO02060930 A3 WO 02060930A3
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WIPO (PCT)
Prior art keywords
ebv
membrane proteins
barr virus
epstein barr
antibody reagents
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PCT/EP2002/000997
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French (fr)
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WO2002060930A2 (en
Inventor
Jaap Michiel Middeldorp
Original Assignee
Cyto Barr B V
Jaap Michiel Middeldorp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyto Barr B V, Jaap Michiel Middeldorp filed Critical Cyto Barr B V
Priority to CN028074696A priority Critical patent/CN1526072B/en
Priority to EP02702332.4A priority patent/EP1368656B1/en
Priority to AU2002235884A priority patent/AU2002235884A1/en
Priority to US10/470,753 priority patent/US20050074749A1/en
Publication of WO2002060930A2 publication Critical patent/WO2002060930A2/en
Publication of WO2002060930A3 publication Critical patent/WO2002060930A3/en
Priority to HK05101441.8A priority patent/HK1068952A1/en
Priority to US11/284,879 priority patent/US7811581B2/en
Priority to US12/857,930 priority patent/US8241639B2/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
    • C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16622—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Described are a method for the identification of extracellular epitopes of Epstein Barr virus (EBV) encoded membrane proteins, expressed on the outer cell surface of EBV-transformed mammalian cells, methods for the selection and preparation of antibody reagents specific for the said epitopes, as well as peptides, comprising extracellular domains of Epstein Barr Virus encoded tumour cell associated membrane proteins, the use of said peptide for immunisation and therapeutic vaccination to induce antibodies and T-cells reactive with said domains, and the use of said antibody reagents for the production of targeting cells, tumour cell purging and as diagnostic for and medicament against EBV-mediated malignant cell growth.
PCT/EP2002/000997 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith WO2002060930A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN028074696A CN1526072B (en) 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
EP02702332.4A EP1368656B1 (en) 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
AU2002235884A AU2002235884A1 (en) 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
US10/470,753 US20050074749A1 (en) 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
HK05101441.8A HK1068952A1 (en) 2001-01-30 2005-02-21 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith
US11/284,879 US7811581B2 (en) 2001-01-30 2005-11-22 Epstein Barr Virus (EBV) tumor-associated latent membrane extracellular domain peptides
US12/857,930 US8241639B2 (en) 2001-01-30 2010-08-17 Extracellular domains of Epstein Barr Virus (EBV) tumor-associated latent membrane proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01200321.6 2001-01-30
EP01200321A EP1229043A1 (en) 2001-01-30 2001-01-30 Peptides derived from Epstein Barr virus (EBV) proteins LMP1, LMP2 and BARF1 antibody reagents reactive therewith

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10470753 A-371-Of-International 2002-01-30
US11/284,879 Continuation US7811581B2 (en) 2001-01-30 2005-11-22 Epstein Barr Virus (EBV) tumor-associated latent membrane extracellular domain peptides

Publications (2)

Publication Number Publication Date
WO2002060930A2 WO2002060930A2 (en) 2002-08-08
WO2002060930A3 true WO2002060930A3 (en) 2003-10-16

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000997 WO2002060930A2 (en) 2001-01-30 2002-01-30 Method for the identification of extracellular domains of the epstein barr virus (ebv), tumor-associated latent membrane proteins and for the selection of antibody reagents reactive therewith

Country Status (6)

Country Link
US (3) US20050074749A1 (en)
EP (2) EP1229043A1 (en)
CN (1) CN1526072B (en)
AU (1) AU2002235884A1 (en)
HK (1) HK1068952A1 (en)
WO (1) WO2002060930A2 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1470159B1 (en) * 2001-12-04 2013-08-07 Dana-Farber Cancer Institute, Inc. Antibody to latent membrane proteins and uses thereof
TW200416043A (en) * 2002-11-07 2004-09-01 Queensland Inst Med Res Epstein barr virus peptide epitopes, polyepitopes and delivery system therefor
FR2850384A1 (en) * 2003-01-28 2004-07-30 Centre Nat Rech Scient New antigen from intracellular pathogens, useful in vaccines against bacterial and viral infections, comprises sequences from extracellular domains of type III membrane proteins, also derived antibodies
FR2881746B1 (en) * 2005-02-07 2007-04-13 Centre Nat Rech Scient CD4 + EPITOPES OF TYTE I AND II LATENCY ANTIGENS OF THE EPSTEIN-BARR VIRUS FIT TO BE RECOGNIZED BY THE MAJORITY OF INDIVIDUALS OF THE CAUCASIAN POPULATION AND THEIR APPLICATIONS
WO2010015704A1 (en) * 2008-08-08 2010-02-11 Centre National De La Recherche Scientifique (Cnrs) Pharmaceutical compositions comprising antibodies binding to ebv (epstein-barr virus) protein barf1
EP2331572A1 (en) * 2008-08-08 2011-06-15 Centre National de la Recherche Scientifique (C.N.R.S) Pharmaceutical compositions comprising antibodies binding to the intracellular domain of ebv (epstein-barr virus) latent membrane protein-1 (lmp1)
WO2012072515A2 (en) 2010-11-29 2012-06-07 Centre National De La Recherche Scientifique (Cnrs) Lmp1 a diagnostic and prognostic marker for epstein-barr virus (ebv)-associated lymphoma
WO2012072516A1 (en) 2010-11-29 2012-06-07 Centre National De La Recherche Scientifique (Cnrs) Barf1 a diagnostic and prognostic marker for epstein-barr virus (ebv)-associated lymphoma
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
AU2012351347B2 (en) 2011-12-12 2016-05-19 Baylor College Of Medicine Process of expanding T cells
ES2928851T3 (en) 2012-02-09 2022-11-23 Baylor College Medicine Pep mixes to generate multiviral CTLs with broad specificity
CN109893648A (en) 2013-06-28 2019-06-18 奥克兰联合服务有限公司 Amino acid conjugate and peptide conjugate and conjugation methods
WO2016103192A1 (en) 2014-12-23 2016-06-30 Margaret Anne Brimble Amino acid and peptide conjugates and uses thereof
JP6999941B2 (en) 2015-09-18 2022-02-10 ベイラー カレッジ オブ メディスン Identification of immunogenic antigens from pathogens and their correlation with clinical efficacy
ITUB20154769A1 (en) * 2015-11-04 2017-05-04 Centro Di Riferimento Oncologico Cro Irccs Aviano Anti-BARF1 monoclonal antibody
EP3419962A4 (en) 2016-02-26 2020-03-11 Auckland Uniservices Limited Amino acid and peptide conjugates and conjugation process
CN113621070A (en) 2020-05-06 2021-11-09 华夏英泰（北京）生物技术有限公司 T cell antigen receptor, polymer compound thereof, preparation method and application thereof
CN111647564B (en) * 2020-05-18 2023-07-04 李欣 anti-EB virus LMP1 monoclonal antibody, cell strain and application thereof
CN112125959B (en) * 2020-10-10 2022-07-29 中山大学肿瘤防治中心 Peptide for inhibiting EB virus, DNA for coding peptide and application thereof
CN114849488B (en) * 2022-03-14 2023-04-07 中国科学院宁波材料技术与工程研究所 Asymmetric wettability forward osmosis membrane and preparation method and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004176A1 (en) * 1988-10-03 1990-04-19 Scripps Clinic And Research Foundation THE RECEPTOR BINDING REGION OF EBVgp350
WO1992000525A1 (en) * 1990-06-29 1992-01-09 E.I. Du Pont De Nemours And Company Assay for detecting and/or quantifying a mammalian antibody response to epstein-barr virus membrane antigen
WO1996020723A1 (en) * 1994-12-30 1996-07-11 Brigham & Women's Hospital Controlling traf-mediated signals
WO2001037868A1 (en) * 1999-11-24 2001-05-31 Oklahoma Medical Research Foundation Assays and therapies for latent viral infection

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990004176A1 (en) * 1988-10-03 1990-04-19 Scripps Clinic And Research Foundation THE RECEPTOR BINDING REGION OF EBVgp350
WO1992000525A1 (en) * 1990-06-29 1992-01-09 E.I. Du Pont De Nemours And Company Assay for detecting and/or quantifying a mammalian antibody response to epstein-barr virus membrane antigen
WO1996020723A1 (en) * 1994-12-30 1996-07-11 Brigham & Women's Hospital Controlling traf-mediated signals
WO2001037868A1 (en) * 1999-11-24 2001-05-31 Oklahoma Medical Research Foundation Assays and therapies for latent viral infection

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
KHANNA R ET AL: "IDENTIFICATION OF CYTOTOXIC T CELL EPITOPES WITHIN EPSTEIN-BARR VIRUS (EBV) ONCOGENE LATENT MEMBRANE PROTEIN 1 (LMP1): EVIDENCE FORHLA A2 SUPERTYPE-RESTRICTED IMMUNE RECOGNITION OF EBV-INFECTED CELLS BY LMP1-SPECIFIC CYTOTOXIC T LYMPHOCYTES", EUROPEAN JOURNAL OF IMMUNOLOGY,WEINHEIM,DE, vol. 28, no. 2, February 1998 (1998-02-01), pages 451 - 458, XP000982569, ISSN: 0014-2980 *
LEEN A ET AL: "Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses.", JOURNAL OF VIROLOGY. UNITED STATES SEP 2001, vol. 75, no. 18, September 2001 (2001-09-01), pages 8649 - 8659, XP001145440, ISSN: 0022-538X *
MEIJ P ET AL: "Restricted low-level human antibody responses against Epstein-Barr virus (EBV)-encoded latent membrane protein 1 in a subgroup of patients with EBV-associated diseases.", THE JOURNAL OF INFECTIOUS DISEASES. UNITED STATES MAY 1999, vol. 179, no. 5, May 1999 (1999-05-01), pages 1108 - 1115, XP009005665, ISSN: 0022-1899 *
ROWE, DAVID T. (1): "Epstein-Barr virus immortalization and latency.", FRONTIERS IN BIOSCIENCE, (MARCH 15, 1999) VOL. 4, NO. CITED MARCH 16, 1999, PP. D346-371. HTTP://WWW.BIOSCIENCE.ORG/ 1999 /V4/D/ROWE/FULLTEXT.HTM., XP002169302 *
STROCKBINE, LAURA D. ET AL: "The Epstein-Barr virus BARF1 gene encodes a novel, soluble colony-stimulating factor-1 receptor.", JOURNAL OF VIROLOGY, (MARCH, 1998) VOL. 72, NO. 5, PP. 4015-4021., XP001000463 *

Also Published As

Publication number Publication date
US20110064759A1 (en) 2011-03-17
WO2002060930A2 (en) 2002-08-08
EP1229043A1 (en) 2002-08-07
EP1368656A2 (en) 2003-12-10
EP1368656B1 (en) 2016-07-13
CN1526072B (en) 2011-09-07
US8241639B2 (en) 2012-08-14
HK1068952A1 (en) 2005-05-06
CN1526072A (en) 2004-09-01
AU2002235884A1 (en) 2002-08-12
US20050074749A1 (en) 2005-04-07
US7811581B2 (en) 2010-10-12
US20060068442A1 (en) 2006-03-30

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