WO2002060469A1 - Anticancer agents - Google Patents

Anticancer agents Download PDF

Info

Publication number
WO2002060469A1
WO2002060469A1 PCT/JP2002/000578 JP0200578W WO02060469A1 WO 2002060469 A1 WO2002060469 A1 WO 2002060469A1 JP 0200578 W JP0200578 W JP 0200578W WO 02060469 A1 WO02060469 A1 WO 02060469A1
Authority
WO
WIPO (PCT)
Prior art keywords
anticancer agents
salt
peptide fragment
agents
antigen
Prior art date
Application number
PCT/JP2002/000578
Other languages
French (fr)
Japanese (ja)
Inventor
Tsukasa Seya
Misako Matsumoto
Kenichiro Naito
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2002060469A1 publication Critical patent/WO2002060469A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)

Abstract

Medicinal compositions such as anticancer agents, T cell differentiation inductive cytokine-inducing agents, immature dendritic cell maturation-inducing agents and the like which contain an M161 antigen peptide fragment, its prodrug or a salt thereof; and a method of screening a substance useful as an anticancer agent, etc. with the use of M161 antigen, its peptide fragment or a salt thereof.
PCT/JP2002/000578 2001-01-29 2002-01-28 Anticancer agents WO2002060469A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-19416 2001-01-29
JP2001019416 2001-01-29

Publications (1)

Publication Number Publication Date
WO2002060469A1 true WO2002060469A1 (en) 2002-08-08

Family

ID=18885296

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000578 WO2002060469A1 (en) 2001-01-29 2002-01-28 Anticancer agents

Country Status (1)

Country Link
WO (1) WO2002060469A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041982A1 (en) * 2003-10-31 2005-05-12 Kurume University Combination therapy of peptide vaccination and estramustine treatment

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
EP1050306A1 (en) * 1998-01-30 2000-11-08 Japan Science and Technology Corporation CYTOKINE INDUCERS COMPRISING M161Ag

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006692A1 (en) * 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
EP1050306A1 (en) * 1998-01-30 2000-11-08 Japan Science and Technology Corporation CYTOKINE INDUCERS COMPRISING M161Ag

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CELLA M. ET AL.: "Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells", NATURE, vol. 388, no. 6644, 1997, pages 782 - 787, XP001079886 *
CHEMICAL ABSTRACTS, vol. 132, 2000, Columbus, Ohio, US; abstract no. 333039 *
GARCIA J. ET AL.: "A mycoplasma fermentans-derived synthetic lipopeptide induces AP-1 and NF-kappaB activity and cytokine secretion in macrophages via the activation of mitogen-activated protein kinase pathways", J. BIOL. CHEM., vol. 273, no. 51, 1998, pages 34391 - 34398, XP002203725 *
KAUFMANN A. ET AL.: "Induction of cytokines and chemokines in human monocytes by mycoplasma fermentans-derived lipoprotein MALP-2", INFECT. IMMUN., vol. 67, no. 12, 1999, pages 6303 - 6308, XP002203724 *
KEN'ICHIRO SHIBATA: "Macrophage aruiwa sen'igasaibo ni taishite cytokine yudokassei o yusuru mycoplasma no saibomaku lipo-tampakushitsu ni tsuite", NIHON SAIKINGAKU ZASSHI, vol. 55, no. 1, 2000, pages 11 - 20, XP002952458 *
MATSUMOTO M. ET AL.: "A novel protein that participates in nonself discrimination of malignant cells by homologous complement", NAT. MED., vol. 3, no. 11, 1997, pages 1266 - 1270, XP002951597 *
NISHIGUCHI M. ET AL.: "Mycoplasma fermentans lipoprotein M161Ag-induced cell activation is mediated by toll-like receptor 2: role of N-terminal hydrophobic portion in its multiple functions", J. IMMUNOL., vol. 166, no. 4, February 2001 (2001-02-01), pages 2610 - 2616, XP002951598 *
SALLUSTO F. ET AL.: "Efficient presentation of soluble antigen by cultured human dendric cells is maintained by granulocyte-macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha", J. EXP. MED., vol. 179, no. 4, 1994, pages 1109 - 1118, XP000611720 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005041982A1 (en) * 2003-10-31 2005-05-12 Kurume University Combination therapy of peptide vaccination and estramustine treatment
WO2005041981A1 (en) * 2003-10-31 2005-05-12 Kurume University Combination therapy of peptide vaccination and estramustine treatment

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