WO2002059571A2 - Support d'echantillons tissulaires - Google Patents

Support d'echantillons tissulaires Download PDF

Info

Publication number
WO2002059571A2
WO2002059571A2 PCT/US2001/051008 US0151008W WO02059571A2 WO 2002059571 A2 WO2002059571 A2 WO 2002059571A2 US 0151008 W US0151008 W US 0151008W WO 02059571 A2 WO02059571 A2 WO 02059571A2
Authority
WO
WIPO (PCT)
Prior art keywords
mating piece
carrier
mating
specimen
piece
Prior art date
Application number
PCT/US2001/051008
Other languages
English (en)
Other versions
WO2002059571A3 (fr
Inventor
Michael G. Nagle
Original Assignee
Nagle Michael G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nagle Michael G filed Critical Nagle Michael G
Priority to AU2002248279A priority Critical patent/AU2002248279A1/en
Publication of WO2002059571A2 publication Critical patent/WO2002059571A2/fr
Publication of WO2002059571A3 publication Critical patent/WO2002059571A3/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0096—Casings for storing test samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/36—Embedding or analogous mounting of samples
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00831—Material properties
    • A61B2017/00902—Material properties transparent or translucent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
    • G01N1/31—Apparatus therefor
    • G01N2001/315—Basket-type carriers for tissues

Definitions

  • the invention relates to a carrier to maintain an excised tissue
  • Mammography is a noninvasive screening method for early
  • mammography is an effective way to detect
  • tissue either in an intact form or in serial sections, may be performed.
  • tissue is malignant, pre-malignant or suspicious cells
  • tissue margins contain malignant, pre-malignant or suspicious
  • tissue samples can be sandwiched and compressed between two plates, with
  • the plates forming a grid for locating a mass within a tissue sample during
  • tissue samples may be contained in carriers that have multiple compartments
  • tissue samples may be contained in molds that vertically orient
  • the invention is directed to a tissue specimen carrier that
  • the carrier has two halves which, after placement of the tissue
  • the carrier includes first and second mating pieces.
  • First mating piece has a
  • piece also has a plurality of sides with at least one side having a grid of
  • one of the two mating pieces is radiographically transparent and the other
  • the mating piece is radiographically dense.
  • the second mating piece is adapted
  • both first and second mating pieces have three mutually perpendicular sides.
  • the sides of the second mating piece may be trimmed
  • tissue specimens may be sized to substantially conform to tissue specimens of various sizes.
  • mating pieces include interiorly projecting spikes adapted to contact the tissue
  • the first mating piece have interiorly opening notches formed therein and
  • Both the first and second mating piece have three mutually
  • the elongated members of the first mating piece slidingly engage
  • tissue specimen is securely held in a known orientation.
  • the tissue specimen is securely held in a known orientation.
  • mating pieces includes interiorly projecting spikes adapted to contact the tissue specimen upon slidingly coupling the second mating piece to the first
  • breast tissue is obtained from a biopsy, a lumpectomy, or a mastectomy.
  • FIG. 1 is a perspective view of the tissue specimen apparatus
  • FIG. 2 is a perspective view of an oriented excised tissue
  • FIG. 3 is a perspective view of a tissue specimen prepared for
  • FIG. 4 is a cross-sectional view of the apparatus taken along line
  • FIG. 5 is a perspective view of another embodiment of a tissue
  • FIG . 6 is a perspective view of a first of the tissue specimen
  • FIG. 7 is a perspective view of a second half of the tissue
  • FIG. 8 is an enlarged disassembled perspective view (as seen
  • FIG. 9 is a cross-section taken along line 9-9 of FIG. 8.
  • FIG. 10 is a cross-section taken along line 10-10 of FIG. 8.
  • FIG . 1 1 is a schematic plan view of a first half of the tissue
  • specimen carrier of FIG. 5 prior to being formed into a three-dimensional
  • FIG. 12 is a perspective view of another embodiment of a tissue
  • FIG . 1 3 is a perspective view of a second half of the tissue
  • FIG. 14 is an elevational end view of the tissue specimen carrier
  • FIG. 1 5 is an elevational side view of the tissue specimen carrier
  • tissue specimen carrier 10 to contain and
  • the excised tissue specimen 1 2 may be a
  • cyst or mass of cells that requires further diagnostic or therapeutic evaluation
  • the carrier 10 comprises an outer
  • compartment or box 20 that is open at at least one face 22 for stably
  • outer box 20 and inner box 24 are preferably
  • box 20 and inner box 24 connected by, for example, a hinge or other
  • a series of different sized carriers 10 are
  • tissue specimen 12 or to contain a smaller-sized specimen 12.
  • tissue specimen 12 or to contain a smaller-sized specimen 12.
  • the carrier 10 is sized to encompass specimens 12 ranging from about 2 x 2 cm to about 10 x 8 cm, and may range from about one to about five times the
  • outer box 20 and inner box 24 are made
  • radiographically transparent material 26 are extruded plastics, which may be
  • edges or beams are preferably thin so the carrier
  • the material 26 is also visually transparent to allow gross
  • the material 26 may have an orientation marking system 39
  • the marking system 39 may be a
  • the system 39 is preferably visible
  • the barbs 33 are preferably
  • the barbs 33 may serve to secure the specimen 12 in the carrier 10.
  • the barbs 33 may
  • the barbs 33 are
  • the carrier 10 is configured so that the material 26 defines a
  • plurality of apertures 30, preferably having a square shape and preferably sized
  • the aperture 30 size is preferably in
  • the apertures 30 are preferably
  • tissue sample 12 is excised
  • sample 12 may be, for example, breast tissue obtained by ultrasonographic or
  • any excised solid tissue specimen preferably requiring orientation with further evaluation such as a cyst or a solid organ specimen,
  • liver biopsy specimen for example, a liver biopsy specimen.
  • the invention permits a tissue specimen 12 to be accurately and
  • the excised specimen 12 is initially oriented by marking the
  • specimen 12 is oriented by placing sutures 40 of varying lengths at one or
  • suture 45 may be placed at a lateral extreme 46 of the specimen 12.
  • the specimen 12 thus oriented is placed into the outer box 20 of
  • the carrier 10 It is particularly convenient to place the specimen 12 into the carrier 10. It is particularly convenient to place the specimen 12 into the carrier 10.
  • the lateral extreme 48 is oriented to the mediolateral (ML) face.
  • the carrier 10 is selected from among a plurality of different-sized
  • appropriately sized carrier 10 permits fixed and stable transport of a
  • any carrier 10 that is either the same size or larger
  • the interior compartment or box 24 is then inserted into the outer
  • compressive force is one that serves to substantially conform the specimen 12
  • specimen 1 2 in a substantially rectangular shape. This shape aids in
  • the force further fixedly maintains the oriented
  • tissue specimen 12 within the carrier 10 and also textures or nubs 50 the
  • specimen 12 is achieved by the regularly spaced, preferably square shaped
  • apertures 30 and facilitates free-hand serial sectioning of the specimen 12.
  • specimen 12 contacts the barbs 33 that inwardly project on an interior surface
  • the inner box 24 is further
  • the inner box 24 is secured in the outer box 20.
  • the inner box 24 is secured in one embodiment.
  • an additional securing means for example, by a straight suture 40 inserted through apertures 30a, 30b (not shown) in both the inner box 24 and outer
  • the specimen 12 that is oriented and fixed in an appropriately
  • the carrier 10 is then subjected to radiography.
  • the carrier 10 is then subjected to radiography.
  • the carrier 10
  • both the radiologist and surgeon view the film and may consult to determine
  • the carrier 10 may be transported for pathological evaluation by
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen subjected to histological processing.
  • the specimen 12 may be any specimen 12
  • fixation system solution such as a solution of 70-30 formyl alcohol (formalin
  • Removal of the specimen 1 2 may be by any means
  • specimen 12 may be removed by grasping a laterally placed suture 45, either
  • the specimen 8 may be removed by cutting through the carrier 10, for
  • any appropriate cutting tool such as a scalpel
  • the specimen 12 is then immediately coded to differentiate each
  • the specimen 1 2 is then sectioned in accordance with standard
  • pathologic technique for example, in a sagittal plane for subsequent
  • the fixed tissue specimen 1 2 is embedded or infiltrated with a
  • embedding matrix may be sectioned together.
  • sections 60 may be further evaluated radiologically. This would be of use, for
  • an early indicator of tumor in the case where microcalcifications, an early indicator of tumor
  • the sections 60 may be placed in cassettes or
  • tissue specimen carrier Another embodiment of a tissue specimen carrier is illustrated in
  • FIGS. 5-1 1 is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference to FIGS. 5-1 1 and is described in greater detail below. With specific reference numeral
  • a tissue specimen carrier 1 00 is comprised of first and second
  • First and second mating pieces 102, 104 are
  • 102, 104 are preferably made of clear plastic and are resistant to chemicals
  • the plastic is sufficiently stiff to ensure that the carrier 1 00 is
  • the carrier 100 is not autoclaveable but may be sterilized
  • first mating piece 102 has three
  • 1 14, 1 1 6 are spaced 1 cm apart, respectively, from adjacent elongated
  • each side 1 08, 1 1 0, 1 1 2 is a 6 cm by 6 cm
  • a plurality of equally spaced spikes 1 1 8 project toward the
  • first mating piece 1 02 from elongated members 1 14, 1 1 6.
  • spikes 1 18 are about 5 mm in length and are spaced 5 mm apart
  • First mating piece 102 is preferably made of a material that is radiographically
  • second mating piece 1 04 is comprised
  • each side 1 22, 124, 1 26 is comprised of an array of elongated members
  • members 1 28, 130 are spaced apart, respectively, 1 cm from one another.
  • each side 1 22, 1 24, 1 26 is a 6 cm by 6 cm square. Elongated
  • members 1 28, 130 further include spikes 1 1 8 which project toward the
  • tissue specimen 1 06 in order to assist in
  • members 128, 130 also include projections 1 32 which are sized to be inserted
  • Second mating piece 104 is not radiographically dense, i.e., it is radiographically translucent or
  • second mating piece 1 04 may
  • tissue specimen carrier 1 00 that is a 6 cm by 6 cm by 6 cm
  • mating piece 1 04 can be cut or trimmed, for example, with a pair of scissors
  • mating pieces 102, 104 can be altered to more closely approximate the size
  • tissue specimen carrier 1 00 For example, a tissue specimen which is
  • enclosure is approximately 4 cm by 4 cm by 4 cm. To that end and in
  • scissors 1 34 are used to cut elongated member
  • the second mating piece 104 would not be trimmed
  • member 114, 116 includes a channel 136 formed in part by opposing walls
  • projection 132 into notch 120, projection 132 includes a flexible lip 142 which
  • Elongated members 114, 116 are preferably 4 mm deep and 1.5
  • Elongated members 128, 130 are of similar dimensions but do
  • Projection 132 has a diameter of about 1.25 mm where flexible lip 142 is
  • first and second mating pieces 102 As shown in FIGS.6 and 7, first and second mating pieces 102,
  • second mating pieces 102, 104 could be manufactured as substantially two- dimensional planar pieces and then folded into three-dimensional pieces.
  • a clamp or band 148 (FIG. 6) is used to secure sides 108,
  • FIGS 1 2-1 5 is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference to FIGS 1 2-1 5 and is described in greater detail below. With specific reference
  • a tissue specimen carrier 200 is comprised of first and second
  • mating pieces 202, 204 are selectively coupled together to securely hold or
  • second mating pieces 202, 204 are preferably made of clear plastic and are
  • the carrier 200 is substantially rigid.
  • the carrier 200 is not autoclaveable
  • First and second mating pieces 202, 204 are essentially identical
  • second mating piece 204 is not radiographically dense, i.e., it is
  • radiographically translucent and may be made from polypropylene not doped
  • first and second mating pieces are essentially identical,
  • first mating piece 202 and like reference numerals will be applicable to first
  • second mating piece 204 is comprised
  • side 21 2 has elongated projections 224 which
  • each edge 21 extends at an angle , preferably 45°, relative to edge 21 8.
  • each edge 21 extends at an angle , preferably 45°, relative to edge 21 8.
  • First and second mating pieces 202, 204 are configured to
  • finger-like members 220 are specifically, and as shown in FIGS. 1 2, 14 and 1 5, finger-like members 220,
  • mating piece 204 mate with finger-like members 224 of side 21 2 of first mating piece 202. Once finger-like members 220, 222 and 224 are mated,
  • first mating piece 202 is slid toward second mating piece 204, as indicated by
  • second mating pieces 202, 204 may include a fastening member (not shown)
  • the fastening member may be a ratcheting
  • the size of the enclosure around tissue specimen 206 can be
  • finger-like members 224 to define a height H and a width W of the enclosure.
  • finger-like members 220, 222 are mated with finger-like
  • first mating piece 202 is
  • tissue specimen 206 having a depth D.
  • the finger-like members 220, 222, 224 not used to form the enclosure, i.e,
  • a carrier for a tissue specimen comprising:
  • a first mating piece having a plurality of sides, at least one side having
  • a second complimentary mating piece having a plurality of sides, at least
  • one side having a grid of intersecting elongated members defining apertures
  • said second mating piece being adapted to selectively couple

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

L'invention concerne un support (100) et un procédé d'utilisation de ce dernier pour orienter et maintenir un échantillon tissulaire prélevé (106) dans une orientation satisfaisante pour déterminer sa position dans un corps. Le support (100) permet le bilan radiologique et pathologique d'un échantillon tissulaire (106) orienté avec précision. Le support (100) comprend une première partie de couplage (102) qui se couple à une seconde partie de couplage (104) pour définir une enceinte destinée à contenir un échantillon tissulaire prélevé (106). Ce dernier est marqué et maintenu dans son orientation in vivo depuis le prélèvement et est évalué pour déterminer l'évaluation et l'orientation d'une tumeur au cours d'un bilan radiologique et/ou pathologique. Le support (100) et le procédé augmentent la précision et l'efficacité de diagnostic et de tout traitement ultérieur.
PCT/US2001/051008 2000-10-25 2001-10-24 Support d'echantillons tissulaires WO2002059571A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002248279A AU2002248279A1 (en) 2000-10-25 2001-10-24 Tissue specimen carrier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69632800A 2000-10-25 2000-10-25
US09/696,328 2000-10-25

Publications (2)

Publication Number Publication Date
WO2002059571A2 true WO2002059571A2 (fr) 2002-08-01
WO2002059571A3 WO2002059571A3 (fr) 2004-04-08

Family

ID=24796598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/051008 WO2002059571A2 (fr) 2000-10-25 2001-10-24 Support d'echantillons tissulaires

Country Status (2)

Country Link
AU (1) AU2002248279A1 (fr)
WO (1) WO2002059571A2 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1493387A2 (fr) * 2003-07-03 2005-01-05 Radi Medical Systems Ab Grille pour l'utilisation dans une biopse guidée par CT
WO2009144202A2 (fr) 2008-05-31 2009-12-03 Klinika Medical Gmbh Ensemble de transport et/ou de conservation d'un échantillon tissulaire humain ou animal
US8449477B2 (en) * 2005-03-02 2013-05-28 Dune Medical Devices Ltd. Device and method for transporting and handling tissue
JP2014226226A (ja) * 2013-05-20 2014-12-08 独立行政法人放射線医学総合研究所 固定位置表示キットおよび位置表示固定方法
EP3058877A1 (fr) * 2015-02-23 2016-08-24 FWB Kunststofftechnik GmbH Dispositif de transport, d'analyse et/ou de stockage d'un echantillon de tissu

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002735A (en) * 1988-07-12 1991-03-26 Mark T. Alberhasky Tissue analysis device
US5127537A (en) * 1991-06-05 1992-07-07 Graham Donald R Tissue cassette with a living hinge
US5568534A (en) * 1994-07-08 1996-10-22 Watkins; Joseph T. Apparatus and method for securing, transporting and analyzing a specimen
US5609827A (en) * 1995-05-02 1997-03-11 Beekley Corporation Biopsy specimen container
US6225107B1 (en) * 1998-11-10 2001-05-01 Michael G. Nagle Tissue specimen carrier

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002735A (en) * 1988-07-12 1991-03-26 Mark T. Alberhasky Tissue analysis device
US5127537A (en) * 1991-06-05 1992-07-07 Graham Donald R Tissue cassette with a living hinge
US5568534A (en) * 1994-07-08 1996-10-22 Watkins; Joseph T. Apparatus and method for securing, transporting and analyzing a specimen
US5609827A (en) * 1995-05-02 1997-03-11 Beekley Corporation Biopsy specimen container
US6225107B1 (en) * 1998-11-10 2001-05-01 Michael G. Nagle Tissue specimen carrier

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1493387A2 (fr) * 2003-07-03 2005-01-05 Radi Medical Systems Ab Grille pour l'utilisation dans une biopse guidée par CT
EP1493387A3 (fr) * 2003-07-03 2005-03-02 Radi Medical Systems Ab Grille pour l'utilisation dans une biopse guidée par CT
US7086172B2 (en) 2003-07-03 2006-08-08 Radi Medical Systems Ab Grid for guided operations
US8449477B2 (en) * 2005-03-02 2013-05-28 Dune Medical Devices Ltd. Device and method for transporting and handling tissue
WO2009144202A2 (fr) 2008-05-31 2009-12-03 Klinika Medical Gmbh Ensemble de transport et/ou de conservation d'un échantillon tissulaire humain ou animal
WO2009144202A3 (fr) * 2008-05-31 2010-07-15 Klinika Medical Gmbh Ensemble de transport et/ou de conservation d'un échantillon tissulaire humain ou animal
US8173421B2 (en) 2008-05-31 2012-05-08 Klinica Medical Gmbh Arrangement for transport and/or safekeeping of a human or animal tissue sample
JP2014226226A (ja) * 2013-05-20 2014-12-08 独立行政法人放射線医学総合研究所 固定位置表示キットおよび位置表示固定方法
EP3058877A1 (fr) * 2015-02-23 2016-08-24 FWB Kunststofftechnik GmbH Dispositif de transport, d'analyse et/ou de stockage d'un echantillon de tissu
DE102015002109A1 (de) * 2015-02-23 2016-08-25 Abdolhamid Huschmand Nia Anordnung zur dreidimensionalen Fixierung einer menschlichen Gewebeprobe zur radiologischen und pathologischen Untersuchung

Also Published As

Publication number Publication date
WO2002059571A3 (fr) 2004-04-08
AU2002248279A1 (en) 2002-08-06

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