WO2002059322A3 - Compositions and methods relating to the daptomycin biosynthetic gene cluster - Google Patents

Compositions and methods relating to the daptomycin biosynthetic gene cluster Download PDF

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Publication number
WO2002059322A3
WO2002059322A3 PCT/US2001/032354 US0132354W WO02059322A3 WO 2002059322 A3 WO2002059322 A3 WO 2002059322A3 US 0132354 W US0132354 W US 0132354W WO 02059322 A3 WO02059322 A3 WO 02059322A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene cluster
daptomycin
compositions
nucleic acid
biosynthetic gene
Prior art date
Application number
PCT/US2001/032354
Other languages
French (fr)
Other versions
WO2002059322A2 (en
WO2002059322A9 (en
Inventor
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Christopher J Silva
Original Assignee
Cubist Pharmaceuticlas Inc
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Christopher J Silva
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cubist Pharmaceuticlas Inc, Vivian Pak Woon Miao, Paul Brian, Richard H Baltz, Christopher J Silva filed Critical Cubist Pharmaceuticlas Inc
Priority to US10/211,028 priority Critical patent/US20050027113A1/en
Priority to AU2002324580A priority patent/AU2002324580A1/en
Priority to JP2003519229A priority patent/JP2005508622A/en
Priority to ARP020102905A priority patent/AR036202A1/en
Priority to KR10-2004-7001843A priority patent/KR20040032891A/en
Priority to EP02759231A priority patent/EP1421097A4/en
Priority to KR1020107004815A priority patent/KR20100039443A/en
Priority to IL16016902A priority patent/IL160169A0/en
Priority to PCT/US2002/024310 priority patent/WO2003014297A2/en
Priority to CA002456552A priority patent/CA2456552A1/en
Publication of WO2002059322A2 publication Critical patent/WO2002059322A2/en
Publication of WO2002059322A9 publication Critical patent/WO2002059322A9/en
Publication of WO2002059322A3 publication Critical patent/WO2002059322A3/en
Priority to US11/510,972 priority patent/US20070128694A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention provides nucleic acid molecules comprising all or a part of a daptomycin biosynthetic gene cluster. The daptomycin biosynthethic gene cluster may be derived from Streptomyces, preferably from S. roseosporus. The invention also provides other nucleic acid molecules from S. roseosporus. The invention further provides polypeptides encoded by the nucleic acid molecules, antibodies that specifically bind to the polypeptides, and methods of using the nucleic acid molecules, polypeptides and antibodies to produce daptomycin and other compounds.
PCT/US2001/032354 2000-10-17 2001-10-17 Compositions and methods relating to the daptomycin biosynthetic gene cluster WO2002059322A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
EP02759231A EP1421097A4 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
IL16016902A IL160169A0 (en) 2001-08-06 2002-07-31 Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
JP2003519229A JP2005508622A (en) 2001-08-06 2002-07-31 Compositions and methods for daptomycin biosynthetic gene clusters
ARP020102905A AR036202A1 (en) 2001-08-06 2002-07-31 COMPOSITIONS AND METHODS RELATED TO THE DAPTOMYCINE BIOSINTETIC GENETIC CLUSTER
KR10-2004-7001843A KR20040032891A (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
US10/211,028 US20050027113A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
KR1020107004815A KR20100039443A (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
AU2002324580A AU2002324580A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
PCT/US2002/024310 WO2003014297A2 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
CA002456552A CA2456552A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
US11/510,972 US20070128694A1 (en) 2001-08-06 2006-08-28 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US24087900P 2000-10-17 2000-10-17
US60/240,879 2000-10-17
US27220701P 2001-02-28 2001-02-28
US60/272,207 2001-02-28
US31038501P 2001-08-06 2001-08-06
US60/310,385 2001-08-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/211,028 Continuation-In-Part US20050027113A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster
US11/510,972 Continuation-In-Part US20070128694A1 (en) 2001-08-06 2006-08-28 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Publications (3)

Publication Number Publication Date
WO2002059322A2 WO2002059322A2 (en) 2002-08-01
WO2002059322A9 WO2002059322A9 (en) 2003-05-01
WO2002059322A3 true WO2002059322A3 (en) 2003-10-30

Family

ID=27399410

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/032354 WO2002059322A2 (en) 2000-10-17 2001-10-17 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Country Status (1)

Country Link
WO (1) WO2002059322A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107267434B (en) * 2017-08-08 2021-03-26 浙江大学 Streptomyces roseosporus L31 with high yield of daptomycin and construction method thereof

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1932853A1 (en) 2001-08-06 2008-06-18 Cubist Pharmaceutical Inc. Novel depsipeptides and process for preparing same
US7235651B2 (en) 2001-12-26 2007-06-26 Cubist Pharmaceuticals, Inc. Genes and proteins involved in the biosynthesis of lipopeptides
AU2002351636A1 (en) * 2001-12-26 2003-07-30 Ecopia Biosciences Inc. Genes and proteins involved in the biosynthesis of lipopeptides
US7317001B2 (en) 2002-06-06 2008-01-08 Oscient Pharmaceuticals Corporation Use of ramoplanin to treat diseases associated with the use of antibiotics
US7326782B2 (en) * 2003-08-21 2008-02-05 Wisconsin Alumni Research Foundation Metabolic engineering of viomycin biosynthesis
US8044186B2 (en) 2007-05-11 2011-10-25 Wisconsin Alumni Research Foundation Heterologous production of capreomycin and generation of new capreomycin derivatives through metabolic engineering
CN105531367A (en) 2013-03-15 2016-04-27 模块遗传学公司 Generation of acyl amino acids
US10377699B2 (en) * 2013-11-06 2019-08-13 The University Of Hong Kong Daptomycin analogues and a method for the preparation of daptomycin or a daptomycin analogue
WO2017011592A1 (en) 2015-07-13 2017-01-19 Modular Genetics, Inc. Generation of acyl alcohols
CN112522218B (en) * 2020-12-08 2022-07-22 山东大学 Key exchange structural domain for controlling lipopeptide lipid chain length change and mutant and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061599A2 (en) * 1998-05-28 1999-12-02 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
WO2000053737A2 (en) * 1999-03-12 2000-09-14 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061599A2 (en) * 1998-05-28 1999-12-02 Kosan Biosciences, Inc. Recombinant narbonolide polyketide synthase
WO2000053737A2 (en) * 1999-03-12 2000-09-14 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BALTZ R H: "Genetic manipulation of antibiotic-producing Streptomyces", TRENDS IN MICROBIOLOGY, ELSEVIER SCIENCE LTD., KIDLINGTON, GB, vol. 6, no. 2, February 1998 (1998-02-01), pages 76 - 83, XP002228756, ISSN: 0966-842X *
MCHENNEY M A ET AL: "GENE TRANSFER AND TRANSPOSITION MUTAGENESIS IN STREPTOMYCES ROSEOSPORUS: MAPPING OF INSERTION THAT INFLUENCE DAPTOMYCIN OR PIGMENT PRODUCTION", MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, READING, GB, vol. 142, no. 9, September 1996 (1996-09-01), pages 2363 - 2373, XP000946801, ISSN: 1350-0872 *
MCHENNEY MARGARET A ET AL: "Molecular cloning and physical mapping of the daptomycin gene cluster from Streptomyces roseosporus.", JOURNAL OF BACTERIOLOGY, vol. 180, no. 1, January 1998 (1998-01-01), pages 143 - 151, XP002238497, ISSN: 0021-9193 *
STEIN TORSTEN ET AL: "The multiple carrier model of nonribosomal peptide biosynthesis at modular multienzymatic templates.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 26, 1996, pages 15428 - 15435, XP002238498, ISSN: 0021-9258 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107267434B (en) * 2017-08-08 2021-03-26 浙江大学 Streptomyces roseosporus L31 with high yield of daptomycin and construction method thereof

Also Published As

Publication number Publication date
WO2002059322A2 (en) 2002-08-01
WO2002059322A9 (en) 2003-05-01

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