WO2002057433A3 - Hipk-kinasen zur verwendung in der beeinflussung von zellteilung und zellproliferation - Google Patents

Hipk-kinasen zur verwendung in der beeinflussung von zellteilung und zellproliferation Download PDF

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Publication number
WO2002057433A3
WO2002057433A3 PCT/EP2002/000557 EP0200557W WO02057433A3 WO 2002057433 A3 WO2002057433 A3 WO 2002057433A3 EP 0200557 W EP0200557 W EP 0200557W WO 02057433 A3 WO02057433 A3 WO 02057433A3
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WO
WIPO (PCT)
Prior art keywords
same
nucleic acid
hipk2
homeodomain
cell proliferation
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Application number
PCT/EP2002/000557
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English (en)
French (fr)
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WO2002057433A2 (de
WO2002057433A9 (de
Inventor
Thomas Hofmann
Lienhard Schmitz
Wulf Droege
Andreas Moeller
Hans Will
Sirma Hueseyin
Original Assignee
Deutsches Krebsforsch
Thomas Hofmann
Lienhard Schmitz
Wulf Droege
Andreas Moeller
Hans Will
Sirma Hueseyin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Deutsches Krebsforsch, Thomas Hofmann, Lienhard Schmitz, Wulf Droege, Andreas Moeller, Hans Will, Sirma Hueseyin filed Critical Deutsches Krebsforsch
Priority to AU2002235856A priority Critical patent/AU2002235856A1/en
Publication of WO2002057433A2 publication Critical patent/WO2002057433A2/de
Publication of WO2002057433A9 publication Critical patent/WO2002057433A9/de
Publication of WO2002057433A3 publication Critical patent/WO2002057433A3/de

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Die Erfindung betrifft die Verwendung von HIPK-Kinasen, insbesondere von HIPK2-Kinasen, sowie der dafür kodierenden Nukleinsäuresequenzen zur Beeinflussung der Zellteilung und Zellproliferation, insbesondere die Verwendung in Verfahren zur Diagnose oder Behandlung von Krankheiten, die mit anomaler oder übermäßiger Zellproliferation assoziiert sind, z.B. von Tumorerkrankungen. Die Erfindung betrifft auch die Verwendung von HIPK-Kinasen, insbesondere von HIPK2-Kinase, sowie der dafür kodierenden Nukleinsäuresequenzen und spezifischen Bindungspartnern dafür zur Identifizierung und/oder Herstellung von Substanzen, welche die Zellteilung oder das Zellwachstum hemmen, stimulieren oder auf ander Weise beeinflussen können. Die Erfindung betrifft insbesondere eine human HIPK2-Kinase und Derivate und Fragmente davon, die dafür kodierenden Nukleinsäuresequenzen sowie Antikörper und andere spezifische Bindungspartner für die humane HIPK2-Kinase und die dafür kodierende Nukleinsäuresequenz.
PCT/EP2002/000557 2001-01-22 2002-01-21 Hipk-kinasen zur verwendung in der beeinflussung von zellteilung und zellproliferation WO2002057433A2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002235856A AU2002235856A1 (en) 2001-01-22 2002-01-21 Homeodomain-interacting protein kinases and the use of the same for influencing cell division and cell proliferation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2001102797 DE10102797A1 (de) 2001-01-22 2001-01-22 HIPK-Kinasen und deren Verwendung zur Beeinflussung der Zellteilung und Zellproliferation
DE10102797.4 2001-01-22

Publications (3)

Publication Number Publication Date
WO2002057433A2 WO2002057433A2 (de) 2002-07-25
WO2002057433A9 WO2002057433A9 (de) 2002-10-31
WO2002057433A3 true WO2002057433A3 (de) 2003-05-01

Family

ID=7671398

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000557 WO2002057433A2 (de) 2001-01-22 2002-01-21 Hipk-kinasen zur verwendung in der beeinflussung von zellteilung und zellproliferation

Country Status (3)

Country Link
AU (1) AU2002235856A1 (de)
DE (1) DE10102797A1 (de)
WO (1) WO2002057433A2 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1486506A1 (de) * 2003-06-10 2004-12-15 Institut National De La Sante Et De La Recherche Medicale (Inserm) Proteinkomplexe bestehend aus Herpes simplex Virusprotein US11 und HIPK2-Protein sowie deren Verwendung
WO2007095321A2 (en) * 2006-02-14 2007-08-23 President And Fellows Of Harvard College Mitotic progression genes and methods of modulating mitosis
FR2956409A1 (fr) * 2010-02-15 2011-08-19 Univ Claude Bernard Lyon Procedes pour optimiser la production virale par l'inactivation ou l'inhibition du gene hipk2 et cellules modifiees pour la production virale

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2383244A1 (en) * 1999-05-28 2000-12-07 Sugen, Inc. Protein kinases

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE NCBI [online] 20 December 2000 (2000-12-20), HUG H.: "The HIPK2 protein kinase activates the tumor suppressor protein p53", XP002211255, Database accession no. AF208291 *
D'ORAZI GABRIELLA ET AL: "Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.", NATURE CELL BIOLOGY. ENGLAND JAN 2002, vol. 4, no. 1, January 2002 (2002-01-01), pages 11 - 19, XP001099171, ISSN: 1465-7392 *
HOFMANN THOMAS G ET AL: "Human homeodomain-interacting protein kinase-2 (HIPK2) is a member of the DYRK family of protein kinases and maps to chromosome 7q32-q34.", BIOCHIMIE (PARIS), vol. 82, no. 12, December 2000 (2000-12-01), pages 1123 - 1127, XP002211253, ISSN: 0300-9084 *
HOFMANN THOMAS G ET AL: "Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2.", NATURE CELL BIOLOGY. ENGLAND JAN 2002, vol. 4, no. 1, January 2002 (2002-01-01), pages 1 - 10, XP001099169, ISSN: 1465-7392 *
KIM ET AL: "Homeodomain-interacting Protein Kinases, a novel Family of Co-repressors", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 273, no. 40, 2 October 1998 (1998-10-02), pages 25875 - 25879, XP002208114, ISSN: 0021-9258 *
LI XIN ET AL: "The serine/threonine kinase HIPK2 interacts with TRADD, but not with CD95 or TNF-R1 in 293T cells.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 277, no. 2, 22 October 2000 (2000-10-22), pages 513 - 517, XP002211252, ISSN: 0006-291X *
ROCHAT-STEINER V ET AL: "FIST/HIPK3: a Fas/FADD-interacting serine/threonine kinase that induces FADD phosphorylation and inhibits fas-mediated Jun NH(2)-terminal kinase activation.", THE JOURNAL OF EXPERIMENTAL MEDICINE. UNITED STATES 16 OCT 2000, vol. 192, no. 8, 16 October 2000 (2000-10-16), pages 1165 - 1174, XP002211254, ISSN: 0022-1007 *

Also Published As

Publication number Publication date
DE10102797A1 (de) 2003-05-08
AU2002235856A1 (en) 2002-07-30
WO2002057433A2 (de) 2002-07-25
WO2002057433A9 (de) 2002-10-31

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