WO2002055713A3 - 58848, un membre de la famille des proteine kinases humaines et utilisations de celui-ci - Google Patents

58848, un membre de la famille des proteine kinases humaines et utilisations de celui-ci Download PDF

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Publication number
WO2002055713A3
WO2002055713A3 PCT/US2001/044346 US0144346W WO02055713A3 WO 2002055713 A3 WO2002055713 A3 WO 2002055713A3 US 0144346 W US0144346 W US 0144346W WO 02055713 A3 WO02055713 A3 WO 02055713A3
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
protein kinase
family member
human protein
Prior art date
Application number
PCT/US2001/044346
Other languages
English (en)
Other versions
WO2002055713A2 (fr
Inventor
Rosana Kapeller-Libermann
Susan Acton
Original Assignee
Millennium Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Millennium Pharmaceuticals, Inc. filed Critical Millennium Pharmaceuticals, Inc.
Publication of WO2002055713A2 publication Critical patent/WO2002055713A2/fr
Publication of WO2002055713A3 publication Critical patent/WO2002055713A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des molécules d'acide nucléique isolées dénommées molécules d'acide nucléique 58848, qui codent pour des nouvelles protéine kinases. L'invention concerne également des molécules d'acide nucléique antisens, des vecteurs d'expression recombinés contenant les molécules d'acide nucléique 58848, les cellules hôtes dans lesquelles ces vecteurs d'expression ont été introduits et des animaux transgéniques autres que les humains, dans lesquels un gène 58848 a été introduit ou disrupté. L'invention concerne en outre des protéines 58848 isolées, des protéines hybrides, des peptides antigéniques et des anticorps anti-58848. Enfin, l'invention concerne des méthodes de diagnostic et de traitement faisant appel aux compositions décrites.
PCT/US2001/044346 2000-12-08 2001-11-26 58848, un membre de la famille des proteine kinases humaines et utilisations de celui-ci WO2002055713A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25440100P 2000-12-08 2000-12-08
US60/254,401 2000-12-08

Publications (2)

Publication Number Publication Date
WO2002055713A2 WO2002055713A2 (fr) 2002-07-18
WO2002055713A3 true WO2002055713A3 (fr) 2002-10-31

Family

ID=22964166

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/044346 WO2002055713A2 (fr) 2000-12-08 2001-11-26 58848, un membre de la famille des proteine kinases humaines et utilisations de celui-ci

Country Status (1)

Country Link
WO (1) WO2002055713A2 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960938A1 (fr) * 1996-12-27 1999-12-01 Chugai Research Institute for Molecular Medicine Inc. Nouveau gene de serine-threonine kinase
WO2000015770A2 (fr) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Serine/threonine proteines-kinases
WO2001038503A2 (fr) * 1999-11-24 2001-05-31 Sugen, Inc. Nouvelles proteines kinases humaines et enzymes analogues

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960938A1 (fr) * 1996-12-27 1999-12-01 Chugai Research Institute for Molecular Medicine Inc. Nouveau gene de serine-threonine kinase
WO2000015770A2 (fr) * 1998-09-16 2000-03-23 Incyte Pharmaceuticals, Inc. Serine/threonine proteines-kinases
WO2001038503A2 (fr) * 1999-11-24 2001-05-31 Sugen, Inc. Nouvelles proteines kinases humaines et enzymes analogues

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EM_HTG [online] EMBL; 28 April 2000 (2000-04-28), WATERSTON R.H.: "Homo sapiens chromosome UL clone RP11 - 705C4, working draft sequence, 36 unordered pieces", XP002210076, retrieved from EBI Database accession no. AC068038 *
DATABASE EM_HUM [online] EMBL; 4 August 1999 (1999-08-04), DOE JOINT GENOME INSTITUTE STANFORD HUMAN GENOME CENTER: "Homo sapiens chromosome 19 clone CT-2537I9, complete sequence", XP002210075, retrieved from EBI Database accession no. AC008735 *
DATABASE EM_MUS [online] EMBL; 16 October 1997 (1997-10-16), MARRA ET AL.: "vn86h01.r1 Stratagene mouse heart (#937316) Mus musculus cDNA clone IMAGE:1038865 5' mRNA sequence", XP002210077, retrieved from EBI Database accession no. AA624575 *

Also Published As

Publication number Publication date
WO2002055713A2 (fr) 2002-07-18

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