WO2002055659A3 - Modulation antisens de l'expression de la proteine de liaison a l'integrine beta-4 - Google Patents

Modulation antisens de l'expression de la proteine de liaison a l'integrine beta-4 Download PDF

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Publication number
WO2002055659A3
WO2002055659A3 PCT/US2001/050743 US0150743W WO02055659A3 WO 2002055659 A3 WO2002055659 A3 WO 2002055659A3 US 0150743 W US0150743 W US 0150743W WO 02055659 A3 WO02055659 A3 WO 02055659A3
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WIPO (PCT)
Prior art keywords
binding protein
integrin beta
protein expression
antisense modulation
expression
Prior art date
Application number
PCT/US2001/050743
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English (en)
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WO2002055659A2 (fr
Inventor
Frank C. Bennett
Susan M. Freier
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Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to US10/415,324 priority Critical patent/US20060172957A1/en
Priority to AU2002245190A priority patent/AU2002245190A1/en
Publication of WO2002055659A2 publication Critical patent/WO2002055659A2/fr
Publication of WO2002055659A3 publication Critical patent/WO2002055659A3/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés antisens, des compositions et des procédés servant à moduler l'expression de la protéine de liaison à l'intégrine bêta 4. Les compositions comprennent des composés antisens, notamment des oligonucléotides antisens, qui ciblent des acides nucléiques codant pour la protéine de liaison à l'intégrine bêta 4. L'invention concerne aussi des procédés d'utilisation de ces composés pour moduler l'expression de la protéine de liaison à l'intégrine bêta 4 et pour traiter des maladies associées à l'expression de la protéine de liaison à l'intégrine bêta 4.
PCT/US2001/050743 2000-11-17 2001-11-13 Modulation antisens de l'expression de la proteine de liaison a l'integrine beta-4 WO2002055659A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/415,324 US20060172957A1 (en) 2000-11-17 2001-11-13 Antisense modulation of integrin beta 4 binding protein expression
AU2002245190A AU2002245190A1 (en) 2000-11-17 2001-11-13 Antisense modulation of integrin beta 4 binding protein expression

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/716,161 US6355482B1 (en) 2000-11-17 2000-11-17 Antisense inhibition of integrin beta 4 binding protein expression
US09/716,161 2000-11-17

Publications (2)

Publication Number Publication Date
WO2002055659A2 WO2002055659A2 (fr) 2002-07-18
WO2002055659A3 true WO2002055659A3 (fr) 2002-09-26

Family

ID=24877000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/050743 WO2002055659A2 (fr) 2000-11-17 2001-11-13 Modulation antisens de l'expression de la proteine de liaison a l'integrine beta-4

Country Status (3)

Country Link
US (2) US6355482B1 (fr)
AU (1) AU2002245190A1 (fr)
WO (1) WO2002055659A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6355482B1 (en) * 2000-11-17 2002-03-12 Isis Pharmaceuticals, Inc. Antisense inhibition of integrin beta 4 binding protein expression
US20070104716A1 (en) * 2003-11-22 2007-05-10 Sloan-Kettering Institute For Cancer Research Methods for controlling pathological angiogenesis by inhibition of a6b4 integrin
GB0719231D0 (en) 2007-10-03 2007-11-14 Oxford Genome Sciences Uk Ltd Protein

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US6355482B1 (en) * 2000-11-17 2002-03-12 Isis Pharmaceuticals, Inc. Antisense inhibition of integrin beta 4 binding protein expression

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5801154A (en) * 1993-10-18 1998-09-01 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of multidrug resistance-associated protein
US6355482B1 (en) * 2000-11-17 2002-03-12 Isis Pharmaceuticals, Inc. Antisense inhibition of integrin beta 4 binding protein expression

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AKIYAMA, STEVEN K.: "Integrins in cell adhesion and signaling", HUMAN CELL, vol. 9, no. 3, March 1996 (1996-03-01), pages 181 - 186, XP002950878 *
BIFFO ET AL.: "Isolation of a novel beta4 integrin-binding protein (p27BBP) highly expressed in epithelial cells", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 48, 28 November 1997 (1997-11-28), pages 30314 - 30321, XP002950880 *
CHO ET AL.: "Identification and characterization of the inducible murine mast cell gene, imc-415", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 252, September 1998 (1998-09-01), pages 123 - 127, XP002950881 *
LAFLAMME ET AL.: "Integrin cytoplasmic domains as connectors to the cell's signal transduction aparatus", MATRIX BIOLOGY, vol. 16, July 1997 (1997-07-01), pages 153 - 163, XP002950877 *
MILNER ET AL.: "Selecting effective antisense reagents on combinatorial oligonucleotide arrays", NATURE BIOTECHNOLOGY, vol. 15, June 1997 (1997-06-01), pages 537 - 541, XP002950885 *
SANVITO ET AL.: "Expression of a highly conserved protein, p27 BBP, during the progression of human colorectal cancer", CANCER RESEARCH, vol. 60, 1 February 2000 (2000-02-01), pages 510 - 516, XP002950876 *
SANVITO ET AL.: "Localization of p27 beta4 binding protein gene (ITGB4BP) to human chromosome region 20q11.2", GENOMICS, vol. 52, May 1998 (1998-05-01), pages 111 - 112, XP002950883 *
SANVITO ET AL.: "The beta4 integrin interactor p27 BBP/eIF6 is an essential nuclear matrix protein involved in 60S ribosomal subunit assembly", THE JOURNAL OF CELL BIOLOGY, vol. 144, no. 5, 8 March 1999 (1999-03-08), pages 823 - 837, XP002950882 *
SI ET AL.: "Molecular cloning and functional expression of a human cDNA encoding translation initiation factor 6", PROC. NATL. ACAD. SCI. USA, vol. 94, December 1997 (1997-12-01), pages 14285 - 14290, XP002950884 *
WOOD ET AL.: "Cloning and murine translation initiation factor 6 and functional analysis of the homologous sequence YPR016c in saccharomyces cerevisiae", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 17, 23 April 1999 (1999-04-23), pages 11653 - 11659, XP002950879 *

Also Published As

Publication number Publication date
WO2002055659A2 (fr) 2002-07-18
US20060172957A1 (en) 2006-08-03
AU2002245190A1 (en) 2002-07-24
US6355482B1 (en) 2002-03-12

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