WO2002055486A3 - Triazene compounds and use thereof - Google Patents

Triazene compounds and use thereof Download PDF

Info

Publication number
WO2002055486A3
WO2002055486A3 PCT/EP2002/000242 EP0200242W WO02055486A3 WO 2002055486 A3 WO2002055486 A3 WO 2002055486A3 EP 0200242 W EP0200242 W EP 0200242W WO 02055486 A3 WO02055486 A3 WO 02055486A3
Authority
WO
WIPO (PCT)
Prior art keywords
group
compounds
triazene compounds
novel
triazene
Prior art date
Application number
PCT/EP2002/000242
Other languages
German (de)
French (fr)
Other versions
WO2002055486A2 (en
Inventor
Joerg Rademann
Joachim Smerdka
Guenther Jung
Original Assignee
Merck Patent Gmbh
Joerg Rademann
Joachim Smerdka
Guenther Jung
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh, Joerg Rademann, Joachim Smerdka, Guenther Jung filed Critical Merck Patent Gmbh
Priority to JP2002556159A priority Critical patent/JP2004528282A/en
Priority to AU2002231744A priority patent/AU2002231744A1/en
Publication of WO2002055486A2 publication Critical patent/WO2002055486A2/en
Publication of WO2002055486A3 publication Critical patent/WO2002055486A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B41/00—Formation or introduction of functional groups containing oxygen
    • C07B41/12—Formation or introduction of functional groups containing oxygen of carboxylic acid ester groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/22—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond containing chains of three or more nitrogen atoms with one or more nitrogen-to-nitrogen double bonds
    • C07C245/24—Chains of only three nitrogen atoms, e.g. diazoamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/11—Compounds covalently bound to a solid support

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to novel triazene compounds, the use thereof and novel alkylation methods. Said triazene compounds have the general formula, X-Y-Z-N=N-NH-R, where X = an insoluble support material, Y = an atom, or group of atoms, functioning as an electron donor, Z = a preferably electron-rich aryl group, substituted aryl group, heteroaryl group, or substituted heteroaryl group and R is chosen from the group alkyl, cycloalkyl, allyl and benzyl. Said compounds are suitable as alkylating reagents.
PCT/EP2002/000242 2001-01-12 2002-01-12 Triazene compounds and use thereof WO2002055486A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002556159A JP2004528282A (en) 2001-01-12 2002-01-12 Triazene compounds and uses thereof
AU2002231744A AU2002231744A1 (en) 2001-01-12 2002-01-12 Triazene compounds and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10102404.5 2001-01-12
DE2001102404 DE10102404A1 (en) 2001-01-12 2001-01-12 Triazene compounds and their use

Publications (2)

Publication Number Publication Date
WO2002055486A2 WO2002055486A2 (en) 2002-07-18
WO2002055486A3 true WO2002055486A3 (en) 2003-11-13

Family

ID=7671145

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000242 WO2002055486A2 (en) 2001-01-12 2002-01-12 Triazene compounds and use thereof

Country Status (4)

Country Link
JP (1) JP2004528282A (en)
AU (1) AU2002231744A1 (en)
DE (1) DE10102404A1 (en)
WO (1) WO2002055486A2 (en)

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BRAESE, STEFAN ET AL: "Solid - phase synthesis of urea and amide libraries using the T2 triazene linker", JOURNAL OF COMBINATORIAL CHEMISTRY (2000), 2(6), 710-715, XP002230189 *
BRÄSE: "NEW LINKERS FOR SOLID PHASE ORGANIC CHEMISTRY. MULTIDIRECTIONAL (MULTIFUNCTIONAL), BACKBONE AMIDE, AND TRACELESS LINKER", CHIMICA OGGI, vol. 18, 2000, pages 14 - 19, XP000801345 *
DAHMEN, STEFAN ET AL: "The first stable diazonium ion on solid support -investigations on stability and usage as linker and scavenger in solid - phase organic synthesis", ANGEWANDTE CHEMIE, INTERNATIONAL EDITION (2000), 39(20), 3681-3683, XP002230190 *
LAILA A.A.R.: "STRUCTURAL EFFECT ON THE MECHANISTIC PATHWAY OF THE DECOMPOSITION OF 3-ALKYL-1-ARYLTRIAZENES: A KINETIC STUDY", GAZZETTA CHIMICA ITALIANA, vol. 119, 1989, pages 453 - 456, XP008013441 *
RADEMANN J. ET AL.: "ALKYLATING POLYMERS: RESIN-RELEASED CARBENIUM IONS AS VERSATILE REACTIVE INTERMEDIATES IN POLYMER-ASSISTED SOLUTION-PHASE SYNTHESIS", ANGEW. CHEM. INT. ED., vol. 40, no. 2, 2001, pages 381 - 385, XP002230191 *
VIGNOLA, N. ET AL: "Synthesis of alkyl sulfonates from sulfonic acids or sodium sulfonates using solid - phase bound reagents", TETRAHEDRON LETTERS (2001), 42(44), 7833-7836, XP002230192 *

Also Published As

Publication number Publication date
WO2002055486A2 (en) 2002-07-18
DE10102404A1 (en) 2002-07-18
AU2002231744A1 (en) 2002-07-24
JP2004528282A (en) 2004-09-16

Similar Documents

Publication Publication Date Title
AU2690001A (en) Luminescent polymer
DE69937861D1 (en) Use of supported catalysts for the reaction of organic compounds
MY126559A (en) Fungicidal 2-methoxybenzophenones
BR9804214A (en) Compounds.
WO2001017973A3 (en) Novel herbicides
ZA986801B (en) Chemical compound.
PT1089724E (en) Cyano substituted oleanolic acid derivatives as no production inhibitors
EP0355049A3 (en) Heterocyclic compounds
GB0124627D0 (en) Novel compounds
EP1506962A3 (en) Nitrogen-containing aromatic heterocycles
DE69803907D1 (en) Fungicides 2-methoxybenzophenones
AU2001292633A1 (en) Imidate-containing fluoropolymer compositions
WO2001014331A3 (en) Non-quinoline inhibitors of malaria parasites
EP2039693A3 (en) Novel synthesis of irbesartan
EP1975164A3 (en) Octahydrobenzimidazolone compounds as analgetics
EP1106607A3 (en) Uracil compounds and their use
EP1465488A4 (en) Arylamines as inhibitors of chemokine binding to us28
WO2001023362A3 (en) Rate-controlled particles
AUPQ841900A0 (en) Synthesis of cyclic compounds
NO20051009L (en) Synthesis of indolizines
MXPA01008347A (en) Chemical compounds.
WO2001023392A8 (en) Tetracyclic benzimidazole derivatives and combinatorial libraries thereof
WO2001066519A3 (en) Method for preparing pyrimidone derivatives with antifungal activity
WO2002055486A3 (en) Triazene compounds and use thereof
CA2192186A1 (en) Process for the preparation of chiral intermediates useful for the synthesis of antifungal agents

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2002711799

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2002556159

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2002711799

Country of ref document: EP