WO2002055454A3 - Process and product - Google Patents

Process and product Download PDF

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Publication number
WO2002055454A3
WO2002055454A3 PCT/US2002/000657 US0200657W WO02055454A3 WO 2002055454 A3 WO2002055454 A3 WO 2002055454A3 US 0200657 W US0200657 W US 0200657W WO 02055454 A3 WO02055454 A3 WO 02055454A3
Authority
WO
WIPO (PCT)
Prior art keywords
invented
dimethoxycinnamoyl
substituted
solvates
product
Prior art date
Application number
PCT/US2002/000657
Other languages
French (fr)
Other versions
WO2002055454A2 (en
Inventor
Paul G Spoors
Original Assignee
Smithkline Beecham Corp
Paul G Spoors
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp, Paul G Spoors filed Critical Smithkline Beecham Corp
Priority to AU2002234236A priority Critical patent/AU2002234236A1/en
Publication of WO2002055454A2 publication Critical patent/WO2002055454A2/en
Publication of WO2002055454A3 publication Critical patent/WO2002055454A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/54—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/38—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Invented is an improved process for the preparation of substituted N-(3',4'-dimethoxycinnamoyl)-aniline derivatives. Also invented are novel solvates of substituted N-(3',4'-dimethoxycinnamoyl)-aniline derivatives and pharmaceutical compositions prepared from the invented solvates.
PCT/US2002/000657 2001-01-10 2002-01-10 Process and product WO2002055454A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002234236A AU2002234236A1 (en) 2001-01-10 2002-01-10 Process and product

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26074801P 2001-01-10 2001-01-10
US60/260,748 2001-01-10

Publications (2)

Publication Number Publication Date
WO2002055454A2 WO2002055454A2 (en) 2002-07-18
WO2002055454A3 true WO2002055454A3 (en) 2003-05-01

Family

ID=22990449

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000657 WO2002055454A2 (en) 2001-01-10 2002-01-10 Process and product

Country Status (2)

Country Link
AU (1) AU2002234236A1 (en)
WO (1) WO2002055454A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101704953B1 (en) 2006-07-05 2017-02-08 피브로테크 세라퓨틱 피티와이 엘티디 Therapeutic compounds
CN105153188B (en) 2009-10-22 2018-06-01 法博太科制药有限公司 The fused ring analogs of antifibrotic agents
WO2018144620A1 (en) 2017-02-03 2018-08-09 Shire Human Genetic Therapies, Inc. Anti-fibrotic compounds

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486597A (en) * 1981-09-01 1984-12-04 Kissei Pharmaceutical Co., Ltd. Method for the production of nuclear substituted cinnamoylanthranilic acid derivatives
US4587356A (en) * 1981-09-01 1986-05-06 Kissei Pharmaceutical Co., Ltd. Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives
JPS6416755A (en) * 1987-06-23 1989-01-20 Biogal Gyogyszergyar Manufacture of n-(3',4'-dimethoxycinnamoyl)-aniline derivative
US5356620A (en) * 1989-04-04 1994-10-18 Kissei Pharmaceutical Co. Ltd. Pharmaceutical compositions containing N-(3,4-dimethoxycinnamoyl) anthranilic acid

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486597A (en) * 1981-09-01 1984-12-04 Kissei Pharmaceutical Co., Ltd. Method for the production of nuclear substituted cinnamoylanthranilic acid derivatives
US4587356A (en) * 1981-09-01 1986-05-06 Kissei Pharmaceutical Co., Ltd. Process for the production of nuclear substituted cinnamoylanthranilic acid derivatives
US4623724A (en) * 1981-09-01 1986-11-18 Kissei Pharmaceutical Co., Ltd. Method for the production of nuclear substituted cinnamoylanthranilic acid salts
JPS6416755A (en) * 1987-06-23 1989-01-20 Biogal Gyogyszergyar Manufacture of n-(3',4'-dimethoxycinnamoyl)-aniline derivative
US5356620A (en) * 1989-04-04 1994-10-18 Kissei Pharmaceutical Co. Ltd. Pharmaceutical compositions containing N-(3,4-dimethoxycinnamoyl) anthranilic acid

Also Published As

Publication number Publication date
AU2002234236A1 (en) 2002-07-24
WO2002055454A2 (en) 2002-07-18

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