WO2002055069A1 - Use of betaine in functional products having blood pressure lowering effects - Google Patents
Use of betaine in functional products having blood pressure lowering effects Download PDFInfo
- Publication number
- WO2002055069A1 WO2002055069A1 PCT/FI2002/000024 FI0200024W WO02055069A1 WO 2002055069 A1 WO2002055069 A1 WO 2002055069A1 FI 0200024 W FI0200024 W FI 0200024W WO 02055069 A1 WO02055069 A1 WO 02055069A1
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- WO
- WIPO (PCT)
- Prior art keywords
- betaine
- blood pressure
- product
- use according
- glycine betaine
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the present invention relates to the use of betaine in functional products, such as pharmaceutical products, functional food products, food supplements, natural products and the like.
- the present invention relates to the use of betaine in functional products having blood pressure lowering effects, and to methods for lowering blood pressure.
- Betaine has been reported to both improve gut health and to increase the food intake and growth of animals. Betaine has also been found to decrease the body fat of for example fish, chicks, piglets and growing pigs (see e.g. Virtanen, E. et al., Effects of food containing betaine/amino acid additive on the osmotic adaption of young Atlantic Salmon, Salmo salar L. Aquaculture 83 (1989) 109-112; Saundersson, C.L. and McKinlay, J., Changes in body weight, composition and hepatic enzyme activities in response to dietary methionine, betaine and choline levels in growing chicks, British J.
- Betaine has also been reported to have pharmacological effects in animals. For example proline betaine has been reported to prevent perosis in chicks and glycine betaine has been reported to prevent the detrimental effects of coccidiosis in broilers (PCT/FI94/00166). Betaine has also been reported to enhance the reproductive performance of animals (PCT/FI96/00211 ).
- betaine has been reported to reduce increased blood homocysteine levels in patients suffering from any of the three primary types of homocysteinuria (see e.g. Wilcken, D.E.L., Dudman, N.P.B. and Tyrrell, P.A. , Homocystinuria Due to Cystathionine ⁇ -Synthase Deficiency - The Effects of Betaine Treatment in Pyridoxine-Responsive Patients. Metabolism 34 (1985) 12:1 115-1121 ; Surtees, R., Bowron, A., Leonard, J. Pediatr Res. 42 (1997) 577- 582).
- a betaine preparation for the treatment of homocystinuria is commercially available under the trademark Cystadane, Orphan Medical Inc., Minnetonka, MN 55305.
- the product consists of anhydrous betaine as a white, granular, hygroscopic powder which is easily soluble in water. For use, a prescribed amount of the powder is added to water, mixed until completely dissolved, and then immediately orally consumed (Orphan Medical Inc., 13911 Ridgedale Drive, Suite 475, Minnetonka, MN 55305, Cyst 06, revised 1196).
- Other pharmaceutical preparations for reducing homocysteine levels, and optionally containing betaine as one of the ingredients are described e.g. in WO 00/44385, Bogye Gabor, and EP 0 595 005 A1 , Vesta Medicines Ltd.
- a pharmaceutical preparation for the treatment and prevention of transmethylation disorders, such as cardiovascular diseases, is described in WO 00/25764, Merck G.m.b.H.
- the composition preferably comprises three different active components, namely a methyl or methylene donor, a methyl transporter, and a bioflavonoid.
- a composition containing betaine 600 mg, Ca L-5-methyltetrahydrofolate 0.5 mg and isoquercetin 500 mg is described.
- Betaine has also been reported to be useful in treating hepatopathies, in particular fatty liver (Babucke, G. and Sarre, H. Klinische réelle mit Betaincitrat. Med. Klin. 68 (1973) 1109-1113). Betaine has also been suggested to decrease the concentration of serum triglycerides and blood alcohol. However, there are no controlled studies regarding these issues.
- RU 2105509 Dal'nevostochnyjAvemrcheskij institut, describes a beetroot juice called "Red Beet Rose".
- the juice contains sugar syrup, citric acid, and juice from the top parts of beetroots.
- top parts of beetroot are washed, treated with steam in 105 C, ground and pressed.
- the pressed juice is filtered and mixed with sugar syrup and citric acid.
- High blood pressure, or hypertension, is one of the most common diseases in developed countries.
- High blood pressure is defined as a consistent recording of systolic blood pressure of 140 mmHg or higher, diastolic blood pressure of 90 mmHg or higher.
- the two main factors influencing blood pressure are the peripheral resistance, i.e. the width of the arteries into which the blood is being pumped, and the cardiac minute volume, i.e. the amount of blood the hearth pumps.
- blood pressure is very complicatedly regulated and many other factors also play an important role.
- taurine is known to lower blood pressure in essential hypertension and some experimental hypertensive models (Harada, H., Kitazaki, K., Tsujino, T., Watari, Y., Iwata, S., Nonaka, H., Hayashi, T., Takeshita, T., Morimoto, K., Yokoyama, M. Oral taurine supplementation prevents the development of ethanol-induced hypertension in rats. Hypertens Res 23 (2000) 3:277-284). Arginine also seems to lower blood pressure and may inhibit atherogenesis.
- the object of the present invention is to provide a product having such properties. According to the present invention, this object is achieved by the use of betaine.
- the present invention thus relates to the use of betaine for the manufacture of a product for maintaining normal blood pressure or for reducing (elevated) blood pressure.
- the present invention relates to the use of betaine for the manufacture of a product for the treatment or prevention of hypertension.
- the product is an edible product, such as a pharmaceutical product, a food product, a food supplement, a dietary supplement, or a natural product.
- the present invention also relates to a method for maintaining normal blood pressure, comprising administering to a subject betaine in an amount sufficient to achieve the desired result. Furthermore, the present invention relates to a method for reducing
- the present invention also relates to a method for the prevention or treatment of hypertension, comprising administering to a subject in need of such treatment betaine in an amount sufficient to achieve the desired result.
- glycine betaine in the form of betaine anhydride, betaine monohydrate, or a betaine salt, is used.
- the betaine used in accordance with the present invention is prepared synthetically or by chromatographic separation, and, if necessary or desired, converted into a salt or derivative.
- betaine lowers the diastolic blood pressure, in particular.
- the present invention is based on the finding that betaine has a very beneficial lowering effect on blood pressure, and in particular on the diastolic pressure.
- Betaine refers to fully N-methylated amino acids. Betaines are natural products that have an important function in both plant and animal metabolism. One of the most abundant betaines is a glycine derivative in which three methyl groups are attached to the nitrogen atom of the glycine molecule. This betaine compound is usually called betaine, glycinebetaine, trimethylglycine or trimethyl-ammonium acetate, and it has the following structural formula:
- betaines include, for example, alanine betaine, proline betaine and histidine betaine.
- a detailed description of betaines is given by Wyn Jones, R.G. and Storey, R. in The physiology and Biochemistry of Drought Resistance in Plants, ed. Paleg, L.G. and Aspinall, D. Academic Press, Sydney, Australia, 1981 , which is incorporated herein by reference.
- Betaine thus have a bipolar structure and it contains several chemically reactive methyl groups, which it can donate in enzyme-catalyzed reactions. Most organisms are able to synthesize small quantities of betaine e.g. for the methyl function, but they are not able to produce and store large quantities of betaine.
- the best known organisms that accumulate betaine are plants of the genus Chenopodiaceae, such as sugar beet, and some microbes and marine invertebrates. Probably the main reason for these organisms to store betaine is that betaine functions as an osmolyte and thereby protects the cells from the effects of osmotic stress. Betaine has also been observed to stabilize the operation of macromolecules in cell membranes. Human cells also contain betaine.
- betaine In the human body, betaine likewise is involved in methionine metabolism: it donates a methyl group to homocysteine, which in turn turns to methionine.
- the amount of betaine in different organs vary a lot, high amounts are present e.g. in Kupfer cells in the liver and in kidney cells, and betaine is present both in blood and in urine.
- the betaine concentration In plasma from healthy humans, the betaine concentration is about 20-60 umol/l, the concentration being considerable higher in adult males than in adult females.
- the betaine concentration In urine, the betaine concentration is significantly high in neonatals and children under 12 months old, the concentration decreasing, after an initial sharp decline, steadily during childhood (Lever, M., Sizeland, P.C.B., Bason. L.M., Hayman, CM. and Chambers, S . Glycine betaine and praline betaine in human blood and urine. Biochimica et Biophysica Ada 1200 (1994) 259-
- Betaine is thus a compound naturally occurring in human cells, and it is part of our normal diet, present in foods such as sugar beet, spinach, and seafood, in particular molluscs and crustacean.
- Betaine has been safely used in animal feed for over 25 years. Betaine was first used in fish feeds, for salmon and trout, as an attractant and an osmoprotectant during the freshwater/seawater transfer stage (Virtanen et al., 1989, supra). Its use has developed in the last 10 years as an additive for poultry and pig feed as a methyl donor and osmoprotectant. Some studies have indicated that betaine is able to decrease the amount of fat tissue in pigs without affecting the amount of lean tissue (Virtanen and Campbell, 1994, supra).
- Betaine also has been used for several years in the treatment of ho- mocystinuria, and has been demonstrated to be safe, also for use in pediatrics, and without severe adverse effects.
- Betaine can be obtained, for example, from sugar beet by chromatographic methods (see e.g. WO 97/45185, Cultor Ltd., and the description of the background art given therein, particularly on p. 4, 1. 9 - 26; EP 54544 Suomen Sokeri Oy; EP 345511, Suomen Sokeri Oy).
- betaine can be prepared synthetically, by using organic synthesis, biosynthesis or genetechnology. Suitable synthesis routes are described e.g. in WO 00/11142, Cultor Corporation. Betaine is commercially available from Finnfeeds Finland Ltd. Betaine products, such as anhydrous, monohydrate, hydrochloride and concentrated betaine solutions, are also available and can be used in the way described in the current document. Other betaine salts and derivatives can also be used. As examples may be mentioned, in a non-exclusive manner, betaine glutamate or betaine citrate.
- the betaine product is prepared by chromatographic methods, and, when desired, converted into a salt or derivative.
- Sugar beet contains about 0.20% glycine betaine and is regarded as the most preferred starting material for betaine production.
- betaine or a salt thereof is administered to the subject as such or as a component of a pharmaceutical product, a food product, a food supplement, a dietary supplement or a natural product.
- Preferred administration forms include, but are not limited to, pills, capsules, dry powders, granulates, and liquid formulas.
- Betaine is readily dissolved in water or beverages of any kind, such as fruit juices, vegetable juices, nectars, milk products, soft drinks, coffee or tea, beer and other alcoholic drinks, etc. It can also be used in dry form e.g. in milk powder, or instant coffee, tea or cocoa.
- Another major product group comprises salt and sweet snacks of any kind, peanuts, energy bars, hard candy, liquorice sticks and powders, ammonium chloride in liquid, powder or pastille form, confectionery, cookies, chewing gums, dried products, such as dried fruits, vegetables, raisins, and the like.
- betaine in the form of dried powder, granulate or (water) solution is considered as preferred; in these forms, it is easily added to the final product either during or after the preparation thereof.
- the term food is broadly construed, including any edible products which can be in a liquid to solid form, and covering both ready-to-eat products and products to which the product of the invention is added in connection with consumption, as a supplement or to be a constituent of the product.
- foods can be products of beverage industry, confectionery industry, food processing industry, meat processing industry, fish processing industry, baking industry, and dairy industry.
- beverages and snack products are regarded as preferred.
- the final products comprising betaine as a blood pressure lowering substance in accordance with the present invention may thus include, in addition to the betaine, ingredients normally used in such products, and they are prepared according to methods conventionally used in pharmaceutical industry, and food and dietary supplements industry, including beverages and functional products.
- Betaine is used in an amount sufficient to achieve the desired, blood pressure maintaining or lowering effect.
- the amount can vary within a large range, depending e.g. on the health, age, and medication of the subject, and can easily be determined by the physician after the publication of the invention. Suitable added amounts may be e.g. about 0.05 - 20 g betaine per day. Betaine amounts of 0.1-8 g per day, in particular 0.5-6 g per day, are regarded as preferred. In accordance with the present invention, it has been shown that betaine lowers the blood pressure. The examples show that a significant reduction in blood pressure is achieved. Furthermore, the diastolic pressure, in particular, is lowered. This is an important finding, bearing in mind that most pharmaceutical products presently on the market mainly lower the systolic blood pressure.
- betaine exerts its blood pressure lowering effect even in normotensic subjects, i.e. people with normal blood pressure.
- the blood pressure lowering effect of betaine is expected to be even more significant in hypertensive subjects.
- betaine has favourable effects for instance on the oral mucosa, in prevention of cardiovascular disease, as liver protectant, and as osmoprotectant in the kidneys. Betaine is thus suitable for use both as a pharmaceutical agent and as a functional agent having beneficial effects on our overall well-being.
- BMI body mass index
- Serum concentration of total triglycerides had to be ⁇ 3.5 mmol/l and that of total cholesterol ⁇ 7.5 mmol/l.
- Inclusion criteria for fasting concentration of plasma glucose was ⁇ 6J mmol/l.
- Subjects with lipid lowering medication were excluded as well women with perimenopause. Four women were postmenopausal in the control group and 6 were postmenopausal in the betaine group. None of the participants were on a medication for hypertension.
- the subjects were not allowed to use nutrient supplements during the study or one month before the study.
- the subjects had a 4-week run-in period during which they consumed 1 dl/d orange juice with 6 g grapefruit juice per 1 dl orange juice twice a day (1 dl in the morning, 1 dl in the evening). Grapefruit juice was added to simulate the bitter taste of betaine.
- the subjects were on their regular eucaloric diet during this period.
- the intervention period with an hypocaloric (-2100 kJ or -500 kcal) diet the subjects were randomly assigned in two groups (20 for the control group, 22 for the betaine group). The subjects were matched for BMI, gender and menstrual cycle.
- control group consumed orange juice 1 dl twice a day and the betaine group consumed betaine enriched orange juice 1 dl twice a day.
- the amount of betaine was 3 g per 1 dl orange juice, giving a daily betaine dose of 6 g.
- Control group 4 wk 16 wk P-value
- Body weight was measured using the same calibrated electronic scale throughout the study.
- Body composition was measured by a bioelectric impedance (BIA 101S with Bodygram software, Akern S.r.l. Biosearch, Italy). The results are presented in table 3.
- Plasma total homocysteine was determined by a modification of the highpressure liquid chromatographic metod described by Ubbink et al. (Ubbink, J.B., Vermaak, W.J.H., Bissbort, S. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum. J Chromatogr (1991 ) 565:441-446).
- the modified mobile phase consisted of 0.37 mol/l acetate and 0.5 % methanol, pH 4.15.
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Abstract
Description
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2002555803A JP2004520341A (en) | 2001-01-12 | 2002-01-11 | Use of betaine in functional products with blood pressure lowering effects |
EP02716115A EP1357911A1 (en) | 2001-01-12 | 2002-01-11 | Use of betaine in functional products having blood pressure lowering effects |
US10/617,974 US20040043442A1 (en) | 2001-01-12 | 2003-07-11 | Use of betaine in functional products having blood pressure lowering effects |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI20010075 | 2001-01-12 | ||
FI20010075A FI114538B (en) | 2001-01-12 | 2001-01-12 | Use of glycine betaine for the preparation of a blood pressure lowering product |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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US10/617,974 Continuation US20040043442A1 (en) | 2001-01-12 | 2003-07-11 | Use of betaine in functional products having blood pressure lowering effects |
Publications (1)
Publication Number | Publication Date |
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WO2002055069A1 true WO2002055069A1 (en) | 2002-07-18 |
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ID=8559987
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/FI2002/000024 WO2002055069A1 (en) | 2001-01-12 | 2002-01-11 | Use of betaine in functional products having blood pressure lowering effects |
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US (1) | US20040043442A1 (en) |
EP (1) | EP1357911A1 (en) |
JP (1) | JP2004520341A (en) |
FI (1) | FI114538B (en) |
WO (1) | WO2002055069A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004231585A (en) * | 2002-12-05 | 2004-08-19 | Fancl Corp | Composition for reducing in vivo homocysteine level or for suppressing increase thereof |
WO2005006890A2 (en) * | 2003-07-10 | 2005-01-27 | Forest Carl A | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
WO2010100624A1 (en) * | 2009-03-06 | 2010-09-10 | Danisco A/S | Seasoning blend |
GB2465814B (en) * | 2008-06-19 | 2011-10-26 | Tarig Sayed Mustafa Arbab | Method,composition and device for the treatment of enzymes and saccharides disorders |
US8703209B2 (en) | 2003-06-17 | 2014-04-22 | Edward Larry McCleary | Composition and method for modulating hydrogen ion physiology |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE1015608A6 (en) * | 2003-07-15 | 2005-06-07 | Messadek Jallal | TREATMENT arteritis. |
ES2278314T3 (en) * | 2003-04-17 | 2007-08-01 | Jallal Messadek | ORAL FORMULATIONS FOR THE CONTROLLED RELEASE OF THE BETA. |
WO2005103285A2 (en) * | 2004-04-09 | 2005-11-03 | Board Of Regents, The University Of Texas System | Systems and methods for indicating oxidation of consumer products |
BE1016128A6 (en) * | 2004-07-22 | 2006-03-07 | Messadek Jallal | Combination therapy |
WO2006050581A2 (en) * | 2004-11-10 | 2006-05-18 | Jallal Messadek | Betaine as agent against arthropod - or mosquito -borne diseases |
MX2007013486A (en) | 2005-04-27 | 2008-03-14 | Jallal Messadek | Insulins combinations. |
WO2009065193A1 (en) * | 2007-11-21 | 2009-05-28 | Jallal Messadek | Treatment of aspirin resistance with betaine and/or betaine enriched molasses |
KR100943577B1 (en) * | 2009-08-28 | 2010-02-23 | 서울대학교산학협력단 | Composition for regeneration of partially hepatectomized liver comprising betaine |
ES2593618T3 (en) * | 2012-12-18 | 2016-12-12 | Sunstar Suisse Sa | Topical oral composition to relieve the symptoms of dry mouth and for the treatment of canker sores |
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FR2540870A1 (en) * | 1983-02-15 | 1984-08-17 | Provesan Sa | NOVEL DERIVATIVES OF N-IMINOPYRIDINIUM BETA, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS |
US4902718A (en) * | 1988-04-08 | 1990-02-20 | Bayless Robert K | Calcium homeostasis compositions and methods for controlling calcium metabolism |
-
2001
- 2001-01-12 FI FI20010075A patent/FI114538B/en active IP Right Grant
-
2002
- 2002-01-11 WO PCT/FI2002/000024 patent/WO2002055069A1/en not_active Application Discontinuation
- 2002-01-11 EP EP02716115A patent/EP1357911A1/en not_active Withdrawn
- 2002-01-11 JP JP2002555803A patent/JP2004520341A/en active Pending
-
2003
- 2003-07-11 US US10/617,974 patent/US20040043442A1/en not_active Abandoned
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US3090725A (en) * | 1960-02-29 | 1963-05-21 | Burroughs Wellcome Co | Phosphorylated quaternary ammonium compounds of improved oral absorption |
JPS60155115A (en) * | 1984-01-24 | 1985-08-15 | Japan Hosupitaru Supply:Kk | Vasopressor agent |
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EP0781554A1 (en) * | 1995-07-25 | 1997-07-02 | Taiho Pharmaceutical Co., Ltd. | Hydroxyl radical scavenger |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004231585A (en) * | 2002-12-05 | 2004-08-19 | Fancl Corp | Composition for reducing in vivo homocysteine level or for suppressing increase thereof |
US8703209B2 (en) | 2003-06-17 | 2014-04-22 | Edward Larry McCleary | Composition and method for modulating hydrogen ion physiology |
WO2005006890A2 (en) * | 2003-07-10 | 2005-01-27 | Forest Carl A | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
WO2005006890A3 (en) * | 2003-07-10 | 2005-07-14 | Carl A Forest | Foods, beverages, condiments, spices and salad dressings with specialized supplements |
GB2465814B (en) * | 2008-06-19 | 2011-10-26 | Tarig Sayed Mustafa Arbab | Method,composition and device for the treatment of enzymes and saccharides disorders |
WO2010100624A1 (en) * | 2009-03-06 | 2010-09-10 | Danisco A/S | Seasoning blend |
Also Published As
Publication number | Publication date |
---|---|
JP2004520341A (en) | 2004-07-08 |
EP1357911A1 (en) | 2003-11-05 |
US20040043442A1 (en) | 2004-03-04 |
FI114538B (en) | 2004-11-15 |
FI20010075A0 (en) | 2001-01-12 |
FI20010075A (en) | 2002-07-13 |
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