WO2002053742A3 - Proteins and nucleic acids encoding same - Google Patents

Proteins and nucleic acids encoding same Download PDF

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Publication number
WO2002053742A3
WO2002053742A3 PCT/US2002/000375 US0200375W WO02053742A3 WO 2002053742 A3 WO2002053742 A3 WO 2002053742A3 US 0200375 W US0200375 W US 0200375W WO 02053742 A3 WO02053742 A3 WO 02053742A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
nucleic acids
acids encoding
encoding same
disclosed
Prior art date
Application number
PCT/US2002/000375
Other languages
French (fr)
Other versions
WO2002053742A2 (en
Inventor
Ramesh Kekuda
John P Ii Alsobrook
Original Assignee
Curagen Corp
Ramesh Kekuda
John P Ii Alsobrook
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/037,417 external-priority patent/US6903201B2/en
Application filed by Curagen Corp, Ramesh Kekuda, John P Ii Alsobrook filed Critical Curagen Corp
Priority to CA002433782A priority Critical patent/CA2433782A1/en
Priority to EP02707409A priority patent/EP1383893A2/en
Priority to JP2002555249A priority patent/JP2005509400A/en
Publication of WO2002053742A2 publication Critical patent/WO2002053742A2/en
Publication of WO2002053742A3 publication Critical patent/WO2002053742A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/5759—Thymosin or related peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/575—Hormones
    • G01N2333/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70546—Integrin superfamily, e.g. VLAs, leuCAM, GPIIb/GPIIIa, LPAM
    • G01N2333/7055—Integrin beta1-subunit-containing molecules, e.g. CD29, CD49

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
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Abstract

Disclosed herein are nucleic acid sequences that encode polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these human nucleic acids and proteins.
PCT/US2002/000375 2001-01-05 2002-01-07 Proteins and nucleic acids encoding same WO2002053742A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002433782A CA2433782A1 (en) 2001-01-05 2002-01-07 Proteins and nucleic acids encoding same
EP02707409A EP1383893A2 (en) 2001-01-05 2002-01-07 Proteins and nucleic acids encoding same
JP2002555249A JP2005509400A (en) 2001-01-05 2002-01-07 Protein and nucleic acid encoding it

Applications Claiming Priority (18)

Application Number Priority Date Filing Date Title
US26001801P 2001-01-05 2001-01-05
US60/260,018 2001-01-05
US26036001P 2001-01-08 2001-01-08
US60/260,360 2001-01-08
US27241101P 2001-02-28 2001-02-28
US60/272,411 2001-02-28
US27281701P 2001-03-02 2001-03-02
US60/272,817 2001-03-02
US30323101P 2001-07-05 2001-07-05
US60/303,231 2001-07-05
US30506001P 2001-07-12 2001-07-12
US60/305,060 2001-07-12
US31840501P 2001-09-10 2001-09-10
US60/318,405 2001-09-10
US31870001P 2001-09-12 2001-09-12
US60/318,700 2001-09-12
US10/037,417 2002-01-04
US10/037,417 US6903201B2 (en) 2001-01-05 2002-01-04 Proteins and nucleic acids encoding same

Publications (2)

Publication Number Publication Date
WO2002053742A2 WO2002053742A2 (en) 2002-07-11
WO2002053742A3 true WO2002053742A3 (en) 2003-11-06

Family

ID=27578133

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/000375 WO2002053742A2 (en) 2001-01-05 2002-01-07 Proteins and nucleic acids encoding same

Country Status (4)

Country Link
EP (1) EP1383893A2 (en)
JP (1) JP2005509400A (en)
CA (1) CA2433782A1 (en)
WO (1) WO2002053742A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2630499A2 (en) * 2010-10-21 2013-08-28 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077155A2 (en) * 2000-04-06 2001-10-18 Curagen Corporation Orfx polynucleotides and polypeptides
WO2001083516A1 (en) * 2000-05-01 2001-11-08 Massachusetts General Hospital Laminin 15 and uses thereof
WO2001098342A1 (en) * 2000-06-22 2001-12-27 Smithkline Beecham Corporation Novel compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001077155A2 (en) * 2000-04-06 2001-10-18 Curagen Corporation Orfx polynucleotides and polypeptides
WO2001083516A1 (en) * 2000-05-01 2001-11-08 Massachusetts General Hospital Laminin 15 and uses thereof
WO2001098342A1 (en) * 2000-06-22 2001-12-27 Smithkline Beecham Corporation Novel compounds

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
ABTS HARRY FRANK ET AL: "Cloning and characterization of hurpin (protease inhibitor 13): A new skin-specific, UV-repressible serine proteinase inhibitor of the ovalbumin serpin family", JOURNAL OF MOLECULAR BIOLOGY, LONDON, GB, vol. 293, no. 1, 15 October 1999 (1999-10-15), pages 29 - 39, XP002168177, ISSN: 0022-2836 *
CHERNOVA, O.B. ET AL.: "A novel gene, LGI1, from 10Q24 is rearranged and downregulated in malignant brain tumours", ONCOGENE, vol. 17, no. 22, 3 December 1998 (1998-12-03), pages 2873 - 2881, XP009010404 *
DATABASE EMBL [online] 1 February 1997 (1997-02-01), SEEBACHER, T. ET AL.: "Laminin chain, Rattus norvegicus", retrieved from EBI Database accession no. P70636 *
DATABASE EMBL [online] 1 November 1997 (1997-11-01), MINER, J.H. ET AL.: "Laminin alpha-5 chain precursor", retrieved from EBI Database accession no. Q61001 *
DATABASE EMBL [online] 10 April 1998 (1998-04-10), OHARA, O. ET AL.: "KIAAA0533", retrieved from EBI Database accession no. AB011105 *
DATABASE EMBL [online] 17 October 1996 (1996-10-17), SEEBACHER, T.: "Laminin chain; Rattus norvegicus", XP002130943, retrieved from EBI Database accession no. Y08882 *
DATABASE EMBL [online] 24 July 1997 (1997-07-24), DURKIN, M.E. ET AL.: "Laminin alpha 5 chain; Homo sapiens", retrieved from EBI Database accession no. Z95636 *
DATABASE EMBL [online] 4 December 1995 (1995-12-04), MINER, J.H. ET AL.: "Laminin alpha-5 chain; Mus musculus", XP002199856, retrieved from EBI Database accession no. U37501 *
DE VIVO, I. ET AL.: "Growth stimulation of primary B cell precursors by the anti-phosphatase SBF1", PROCEEDINGS OF THE NATURAL ACADEMIE OF SCIENCES, vol. 95, August 1998 (1998-08-01), pages 9471 - 9476, XP002240362 *
DURKIN M E ET AL: "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome2 near the locus for the ragged (Ra) mutation", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 411, no. 2-3, Z95636, 14 July 1997 (1997-07-14), pages 296 - 300, XP004262319, ISSN: 0014-5793, Retrieved from the Internet <URL:EBI> *
MINER JEFFREY H ET AL: "Molecular cloning of a novel laminin chain, alpha-5, and widespread expression in adult mouse tissues", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 48, U37501, 1 December 1995 (1995-12-01), pages 28523 - 28526, XP002199855, ISSN: 0021-9258, Retrieved from the Internet <URL:EBI> *
NAGASE, T. ET AL.: "Prediction of the coding sequences of unidentified human genes. IX The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro", DNA RESEARCH, vol. 5, no. 31, 1998, pages 31 - 39, XP002942509 *
PIERCE, R.A. ET AL.: "Expression patterns of laminin alpha1 and alpha5 in human lung during development", AMERICAN JOURNAL OF RESPIRATORY CELL MOLECULAR BIOLOGY, vol. 23, 2000, pages 742 - 747, XP001148018 *
SEEBACHER, T. ET AL.: "Laminin alpha5, a major transcript of normal and malignant rat liver epithelial cells, is differentially expressed in developin and adult liver", EXPERIMENTAL CELL RESEARCH, vol. 237, Y08882, 1997, pages 70 - 76, XP001148063, Retrieved from the Internet <URL:EBI> *
YU J X ET AL: "MOLECULAR CLONING, TISSUE-SPECIFIC EXPRESSION, AND CELLULAR LOCALIZATION OF HUMAN PROSTASIN MRNA", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 270, no. 22, 2 June 1995 (1995-06-02), pages 13483 - 13489, XP002943936, ISSN: 0021-9258 *

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JP2005509400A (en) 2005-04-14
CA2433782A1 (en) 2002-07-11
EP1383893A2 (en) 2004-01-28
WO2002053742A2 (en) 2002-07-11

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